CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
CP-466722 细胞实验
Cell Line
Concentration
Treated Time
Description
References
GBM12 cells
3 μM
14 days
To evaluate the effect of CP-466722 on TMZ sensitivity, results showed that CP-466722 significantly sensitized GBM12 cells to TMZ
J Neurooncol. 2012 Dec;110(3):349-57.
GBM12TMZ cells
3 μM
14 days
To evaluate the effect of CP-466722 on TMZ sensitivity, results showed that CP-466722 had no significant effect on TMZ-resistant GBM12TMZ cells
J Neurooncol. 2012 Dec;110(3):349-57.
HeLa cells
1-10 µM
30 min
To evaluate the inhibitory effect of CP466722 on ATM kinase activity, the results showed that CP466722 almost completely inhibited ATM cellular activity at concentrations of 6μM and above.
Cancer Res. 2008 Sep 15;68(18):7466-74.
MCF-7 cells
6μM
30 min
To evaluate the inhibitory effect of CP466722 on ATM kinase activity, the results showed that CP466722 inhibited ATM-dependent phosphorylation events.
Cancer Res. 2008 Sep 15;68(18):7466-74.
RH-luciferase (RH-luc) strain
0.702 µM
72 h
To evaluate the inhibitory effect of CP-466722 on the growth of T. gondii, the results showed that CP-466722 had a dose-dependent inhibitory effect on the proliferation of T. gondii, with an IC50 value of 0.702 µM.
Int J Mol Sci. 2024 Jun 25;25(13):6947.
CP-466722 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
Xenograft model
Intraperitoneal injection
10 mg/kg
Once daily for 8 weeks
Inhibition of ATM expression significantly reduced tumor metastasis in A549CisR cells.
J Exp Clin Cancer Res. 2019 Apr 8;38(1):149
BALB/c mice
T. gondii infection model
Oral
20, 40, 60 mg/kg
Once daily for 7 consecutive days
To evaluate the protective effect of CP-466722 on T. gondii-infected mice, the results showed that CP-466722 had a slight protective effect on T. gondii-infected mice.
搜索
