There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Potassium (K+) channels participate in many physiological processes, cardiac function, cell proliferation, neuronal signaling, muscle contractility, immune function, hormone secretion, osmotic pressure, changes in gene expression, and are involved in critical biological functions, and in a variety of diseases[1]. BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models[2]. BMS-191011 (10-100 µg/kg, i.v.) and NS 1619 (0.1-1.0 µg/kg, i.v.) increased the diameter of retinal arterioles without altering systemic blood pressure and heart rate significantly. The vasodilator responses to BMS-191011 were significantly diminished by intravitreal injection of iberiotoxin (an inhibitor of BK(Ca) channels, 20 pmol/eye)[3]. A 29-day treatment with L-citrulline, significantly ameliorated the impaired acetylcholine- and BMS-191011-induced retinal vasodilation in diabetic rats without affecting their plasma glucose levels[4]. BMS 191011 caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction[5].
BMS-191011 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HCC1143 cells
20 µM
2 days
To study the effect of BMS-191011 on the growth of HCC1143 cells, results showed that BMS-191011 inhibited cell growth.
BMC Cancer. 2020 Jun 26;20(1):595
SUM159 cells
20 µM
2 days
To study the effect of BMS-191011 on the growth of SUM159 cells, results showed that BMS-191011 inhibited cell growth.
BMC Cancer. 2020 Jun 26;20(1):595
MDA-MB-231 cells
10-50 µM
5 days
To study the effect of NS11021 on the growth of MDA-MB-231 cells, results showed that NS11021 induced cell death within 5 days.
BMC Cancer. 2020 Jun 26;20(1):595
HEK293T cells
10 μM
BMS-191011 attenuated GAL-021-mediated suppression of BK Ca-channel activity
Biomolecules. 2020 Jan 25;10(2):188
rat cerebral artery smooth muscle cells
3 µM
To investigate the effect of BMS-191011 on BK Ca channels in rat cerebral artery smooth muscle cells, results showed that BMS-191011 induced relaxation, which was inhibited by apelin.
J Cardiovasc Pharmacol. 2018 Apr;71(4):223-232
BMS-191011 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
CBA/CaJ mice
Salicylate-induced tinnitus model
Intraperitoneal injection
0.5 mg/kg
Single dose, 1 hour before testing
BMS-191011 treatment reduced behavioral manifestations of SS-induced tinnitus but did not influence SS-induced increases in auditory brainstem response functions. Local application at the inferior colliculus reversed SS-suppressed spontaneous activity, particularly in the frequency region of the tinnitus percept.
Front Neurosci. 2022 Aug 25;16:763855
Mice
High-dosage vitamin D3-induced vascular calcification model
Intraperitoneal injection
10 mg/kg
Once daily for the first 5 days
BK channel activator BMS191011 significantly ameliorated high-dosage vitamin D3-induced vascular calcification in mice, reducing calcium deposition and content, decreasing Runx2 mRNA and protein expression, and increasing α-SMA mRNA and protein levels
Acta Pharmacol Sin. 2022 Mar;43(3):624-633.
NSG mice
MDA-MB-231 xenograft model
Intratumoral injection
100 μg/kg
Twice a week for 4 weeks
To study the effect of BK channel opener on the growth of MDA-MB-231 xenograft tumors, results showed that BK channel opener significantly slowed tumor growth.
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