Atractylenolide II | Asterolide | Apoptosis Inducer | AmBeed-信号通路专用抑制剂

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Atractylenolide II/苍术内酯 II {[allProObj[0].p_purity_real_show]}

货号：A191904 同义名： 白术内酯II / Asterolide; 2-Atractylenolide

Atractylenolide II是从白术干燥根茎中分离的倍半萜化合物，具有抗增殖、抗黑色素瘤、改善心肌纤维化和神经保护等活性。它通过抑制 STAT3 信号通路来发挥抗黑色素瘤作用。

Atractylenolide II/苍术内酯 II 化学结构
CAS号：73069-14-4

Atractylenolide II/苍术内酯 II 3D分子结构
CAS号：73069-14-4

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Atractylenolide II/苍术内酯 II 纯度/质量文件产品仅供科研

货号：A191904 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

CDK 亚型比较

产品名称	Cdc ↓ ↑	CDK1 ↓ ↑	CDK19 ↓ ↑	CDK2 ↓ ↑	CDK3 ↓ ↑	CDK4 ↓ ↑	CDK5 ↓ ↑	CDK6 ↓ ↑	CDK7 ↓ ↑	CDK8 ↓ ↑	CDK9 ↓ ↑	CLK ↓ ↑	其他靶点	纯度
XL413 HCl	++++ Cdc7, IC50: 3.4 nM													99%+
SU9516		+++ CDK1, IC50: 40 nM		+++ CDK2, IC50: 22 nM		++ CDK4, IC50: 200 nM								99%+
RO-3306		+++ CDK1, Ki: 20 nM											ERK,SGK	98%
R547		++++ CDK1/CyclinB, Ki: 2 nM		++++ CDK2/CyclinE, Ki: 3 nM		++++ CDK4/CyclinD1, Ki: 1 nM								99%+
BMS-265246		++++ CDK1/CyclinB, IC50: 6 nM		++++ CDK2/CyclinE, IC50: 9 nM		+ CDK4/CyclinD, IC50: 230 nM								99%+
NU6027		+ CDK1, Ki: 2.5 μM		+ CDK2, Ki: 1.3 μM									DNA-PK	98%
Purvalanol A	++++ Cdc2/CyclinB, IC50: 4 nM			+++ CDK2/CyclinE, IC50: 35 nM CDK2/CyclinA, IC50: 70 nM		+ CDK4/CyclinD1, IC50: 850 nM								99%+
SCH900776				++ CDK2, IC50: 0.16 μM										99%+
AUZ 454				++++ CDK2(A144C), Kd: 9.7 nM CDK2(C118L), Kd: 18.6 nM										99%+
A-674563 HCl				++ CDK2, Ki: 46 nM									PKA	99%
JNJ-7706621		++++ CDK1/CyclinB, IC50: 9 nM		++++ CDK2/CyclinE, IC50: 3 nM CDK2/CyclinA, IC50: 4 nM	++ CDK3/CyclinE, IC50: 58 nM	+ CDK4/CyclinD1, IC50: 253 nM		++ CDK6/CyclinD1, IC50: 175 nM						99%+
AT7519		++ CDK1/CyclinB, IC50: 210 nM		++ CDK2/CyclinA, IC50: 47 nM	+ CDK3/CyclinE, IC50: 360 nM	++ CDK4/CyclinD1, IC50: 100 nM	+++ CDK5/p35, IC50: 13 nM	++ CDK6/CyclinD3, IC50: 170 nM			++++ CDK9/CyclinT, IC50: <10 nM			98+%
PHA-793887		++ CDK1/CyclinB, IC50: 60 nM		++++ CDK2/CyclinE, IC50: 8 nM CDK2/CyclinA, IC50: 8 nM		++ CDK4/CyclinD1, IC50: 62 nM	++++ CDK5/p25, IC50: 5 nM		++++ CDK7/CyclinH, IC50: 10 nM		++ CDK9/CyclinT1, IC50: 138 nM			99%+
Milciclib		+ CDK1/CyclinB, IC50: 398 nM		++ CDK2/CyclinE, IC50: 363 nM CDK2/CyclinA, IC50: 45 nM		++ CDK4/CyclinD1, IC50: 160 nM	+ CDK5/p35, IC50: 265 nM		++ CDK7/CyclinH, IC50: 150 nM					99%+
Kenpaullone		+ CDK1/CyclinB, IC50: 0.4μM		+ CDK2/CyclinE, IC50: 7.5μM CDK2/CyclinA, IC50: 0.68μM			+ CDK5/p35, IC50: 0.85μM							98%
SNS-032				+++ CDK2/CyclinE, IC50: 48 nM CDK2/CyclinA, IC50: 38 nM			+ CDK5/p35, IC50: 340 nM		++ CDK7/CyclinH, IC50: 62 nM		++++ CDK9/CyclinT, IC50: 4 nM			99%+
Dinaciclib		++++ CDK1, IC50: 3 nM		++++ CDK2, IC50: 1 nM			++++ CDK5, IC50: 1 nM				++++ CDK9, IC50: 4 nM			99%+
PHA-767491 HCl	++++ Cdc7, IC50: 10 nM	+ CDK1, IC50: 250 nM		+ CDK2, IC50: 240 nM			+ CDK5, IC50: 460 nM				+++ CDK9, IC50: 34 nM		MK2	99%
(R)-Roscovitine	+ Cdc2/CyclinB, IC50: 0.65 μM			+ CDK2/CyclinE, IC50: 0.7 μM CDK2/CyclinA, IC50: 0.7 μM			++ CDK5/p35, IC50: 0.16 μM							99%+
Narazaciclib						++++ CDK4/CyclinD1, IC50: 3.87 nM		++++ CDK6/CyclinD1, IC50: 9.82 nM					RET	99%+
Palbociclib						++++ CDK4/CyclinD1, IC50: 11 nM CDK4/CyclinD3, IC50: 9 nM		+++ CDK6/CyclinD2, IC50: 15 nM						99%
Abemaciclib						++++ CDK4, IC50: 2 nM		++++ CDK6, IC50: 10 nM						99%
Ribociclib						++++ CDK4, IC50: 10 nM		+++ CDK6, IC50: 39 nM						98%
Palbociclib isethionate						++++ CDK4/CyclinD1, IC50: 11 nM CDK4/CyclinD3, IC50: 9 nM		+++ CDK6/CyclinD2, IC50: 15 nM						99%+
BS-181 HCl									+++ CDK7, IC50: 21 nM					99%+
(E/Z)-THZ1 2HCl									++++ CDK7, IC50: 3.2 nM					99%+
LDC4297									++++ CDK7, IC50: 0.13 nM					99%+
Senexin A			+ CDK19, Kd: 0.31 μM							+ CDK8, Kd: 0.83 μM				99%
MSC2530818										++++ CDK8, IC50: 2.6 nM				99%+
Wogonin											✔			99%+
Riviciclib HCl		++ CDK1/CyclinB, IC50: 79 nM		+ CDK2/CyclinE, IC50: 2.54 μM CDK2/CyclinA, IC50: 224 nM		++ CDK4/CyclinD1, IC50: 63 nM		+ CDK6/CyclinD3, IC50: 396 nM	+ CDK7/CyclinH, IC50: 2.87 μM		+++ CDK9/CyclinT1, IC50: 20 nM			98%
LDC000067				+ CDK2, IC50: 2.441 μM							++ CDK9, IC50: 44 nM			98%
Flavopiridol		+++ CDK1, IC50: 40 nM		+++ CDK2, IC50: 40 nM		+++ CDK4, IC50: 40 nM		+++ CDK6, IC50: 40 nM	+ CDK7, IC50: 300 nM		+++ CDK9, IC50: 20 nM			99%+
LY2857785									+ CDK7, IC50: 0.246 μM	+++ CDK8, IC50: 0.016 μM	+++ CDK9, IC50: 0.011 μM			99%+
AZD-5438		+++ CDK1, IC50: 16 nM		++++ CDK2, IC50: 6 nM							+++ CDK9, IC50: 20 nM			99%+
ML167												++ CLK4, IC50: 136 nM Dyrk1B , IC50: 1648 nM		99%+
(E/Z)-TG003												+++ mCLK1, IC50: 200 nM mCLK4, IC50: 15 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Atractylenolide II/苍术内酯 II 生物活性

描述	Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese) with anti-proliferative activity.

Atractylenolide II/苍术内酯 II 细胞实验

Cell Line GES-1 cells AGS cells AN3CA cells HCT15 cells HT29 cells Lovo cells SW480 cells	Concentration	Treated Time	Description	References
GES-1 cells	400 μM	48 h	no cytotoxicity	Molecules. 2017 Nov 3;22(11):1886
AGS cells	400 μM	48 h	significantly inhibited cell proliferation and induced apoptosis	Molecules. 2017 Nov 3;22(11):1886
AN3CA cells	0, 25, 50, 100, 200, 400 µM	24, 48, 72 h	Inhibited cell proliferation and glycolysis, induced apoptosis	Molecules. 2024 Feb 21;29(5):939
HCT15 cells	80 μM	24 h	AT-II significantly inhibited the growth and migration abilities of HCT15 cells, with enhanced effects when combined with IFN-γ.	J Cancer. 2024 Jun 11;15(13):4328-4344
HT29 cells	80 μM	24 h	AT-II significantly inhibited the growth and migration abilities of HT29 cells, with enhanced effects when combined with IFN-γ.	J Cancer. 2024 Jun 11;15(13):4328-4344
Lovo cells	50 μg/mL	48 h	Atractylenolide II significantly inhibited the proliferation and viability of Lovo cells and enhanced their sensitivity to 5-fluorouracil, mitomycin, adriamycin, and cisplatin.	J Cell Mol Med. 2019 May;23(5):3151-3165
SW480 cells	50 μg/mL	48 h	Atractylenolide II significantly inhibited the proliferation and viability of SW480 cells and enhanced their sensitivity to 5-fluorouracil, mitomycin, adriamycin, and cisplatin.	J Cell Mol Med. 2019 May;23(5):3151-3165

Atractylenolide II/苍术内酯 II 动物实验

Species BALB/c nude mice and C57BL/6 mice	Animal Model Colorectal cancer xenograft model and lung metastasis model	Administration	Dosage	Frequency	Description	References
BALB/c nude mice and C57BL/6 mice	Colorectal cancer xenograft model and lung metastasis model	Intraperitoneal injection	50 mg/kg	Once daily for 21 days	AT-II alone or in combination with IFN-γ significantly inhibited tumor growth and lung metastasis, and improved the tumor microenvironment.	J Cancer. 2024 Jun 11;15(13):4328-4344

Atractylenolide II/苍术内酯 II 参考文献

[1]Fu XQ, Chou GX, et al. Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II. Exp Dermatol. 2014 Nov;23(11):855-7.

[2]Ye Y, Wang H, et al. Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells. J Ethnopharmacol. 2011 Jun 14;136(1):279-82.

Atractylenolide II/苍术内酯 II 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.30mL

0.86mL

0.43mL

21.52mL

4.30mL

2.15mL

43.04mL

8.61mL

4.30mL

Atractylenolide II/苍术内酯 II 技术信息

CAS号	73069-14-4
分子式	C₁₅H₂₀O₂
分子量	232.32
SMILES Code	O=C1C(C)=C(C[C@@]23[H])[C@@](C[C@@]3(C)CCCC2=C)([H])O1
MDL No.	MFCD09037396

别名	白术内酯II ;Asterolide; 2-Atractylenolide
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(451.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

Atractylenolide II/苍术内酯 II {[allProObj[0].p_purity_real_show]}

Atractylenolide II/苍术内酯 II 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Atractylenolide II/苍术内酯 II 质控信息

Atractylenolide II/苍术内酯 II 生物活性

Atractylenolide II/苍术内酯 II 细胞实验

Atractylenolide II/苍术内酯 II 动物实验

Atractylenolide II/苍术内酯 II 参考文献

Atractylenolide II/苍术内酯 II 实验方案

Atractylenolide II/苍术内酯 II 技术信息

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Atractylenolide II/苍术内酯 II {[allProObj[0].p_purity_real_show]}

Atractylenolide II/苍术内酯 II 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Atractylenolide II/苍术内酯 II 质控信息

Atractylenolide II/苍术内酯 II 生物活性

Atractylenolide II/苍术内酯 II 细胞实验

Atractylenolide II/苍术内酯 II 动物实验

Atractylenolide II/苍术内酯 II 参考文献

Atractylenolide II/苍术内酯 II 实验方案

Atractylenolide II/苍术内酯 II 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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