6-Mercaptopurine Monohydrate is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. 6-MP induced G2/M arrest, delayed S-phase progression, and finally induced apoptosis of neural progenitor cells mediated by p53 in the fetal rat telencephalon[3]. The thiopurine drugs azathioprine and 6-mercaptopurine (6-MP) are well-established in the treatment of inflammatory bowel disease (IBD) [4]. The mode of action of azathioprine is thought to be multifactorial, including conversion to 6-mercaptopurine (which acts as a purine antimetabolite), possible blockade of thiol groups by alkylation, inhibition of several pathways in nucleic acid biosynthesis (preventing proliferation of cells involved in the determination and amplification of the immune response) and damage to DNA through the incorporation of thiopurine analogues. Azathioprine and 6-mercaptopurine are further known to alter lymphocyte function, reduce the number of lamina propria plasma cells and affect natural killer cell function[5]. 6-Mercaptopurine monohydrate (6-MP) was administered intraperitoneally (i.p.) or orally (p.o.) to 2 strains of mice, MS/Ae and CD-1. From the results of an acute toxicity test and a pilot micronucleus test, the doses selected for the final micronucleus test were 12.5-100 mg/kg for the i.p. route and 25-200 mg/kg for the p.o. route[6].
6-Mercaptopurine hydrate/6-巯基嘌呤一水合物 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MES28 cells
10 μM
2 h
6-MP competitively inhibits HPRT1 activity, blocks TMZ-induced AMPK activation and RRM1 T52 phosphorylation, thereby enhancing TMZ sensitivity in glioblastoma cells
Nat Commun. 2023 Sep 22;14(1):5913.
U87 cells
10 μM
2 h
6-MP competitively inhibits HPRT1 activity, blocks TMZ-induced AMPK activation and RRM1 T52 phosphorylation, thereby enhancing TMZ sensitivity in glioblastoma cells
Nat Commun. 2023 Sep 22;14(1):5913.
6-Mercaptopurine hydrate/6-巯基嘌呤一水合物 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Abcc4−/− mice
100 mg/kg
Daily administration for 10 days
To study the role of ABCC4 in protecting megakaryocytes from 6-Mercaptopurine toxicity, results showed that Abcc4?/? mice had a significant reduction in megakaryocytes and impaired platelet production after 6-MP treatment.
Drug Resist Updat. 2024 Jan;72:101017
Nude mice
Intracranial glioblastoma model
Intraperitoneal injection
20 mg/kg
5 consecutive days
Combined treatment with 6-MP and TMZ significantly inhibits tumor growth, prolongs mouse survival, and enhances TMZ-induced DNA damage and apoptosis
Denmark
... 展开 >> Department of Pediatrics, Rigshospitalet
Copenhagen, Denmark, 2100
Finland
Helsinki University Hospital
Helsinki, Finland
Iceland
University Hospital Reykjavik, Iceland
Reykjavik, Iceland
Norway
Trondheim University Hospital
Trondheim, Norway
Sweden
Department of Pediatrics, Drottning Sylvias Pediatric Hospital
Gothenburg, Sweden
NOPHO nordic organisation for pediatric onology
Stockholm, Sweden 收起 <<
Denmark
... 展开 >> Department of Pediatrics, Rigshospitalet
Copenhagen, Denmark, 2100
Finland
Helsinki University Hospital
Helsinki, Finland
Iceland
University Hospital Reykjavik, Iceland
Reykjavik, Iceland
Norway
Trondheim University Hospital
Trondheim, Norway
Sweden
Department of Pediatrics, Drottning Sylvias Pediatric Hospital
Gothenburg, Sweden
NOPHO nordic organisation for pediatric onology
Stockholm, Sweden 收起 <<
United States, Arizona
... 展开 >>
Phoenix Children's Hospital
Recruiting
Phoenix, Arizona, United States, 85006
Contact: Michael Henry, MD mhenry@phoenixchildrens.com
Principal Investigator: Michael Henry, MD
United States, Arkansas
Arkansas Children's Hospital
Recruiting
Little Rock, Arkansas, United States, 72202
Contact: Kimo Stine, MD stinekimoc@uams.edu
Principal Investigator: Kimo Stine, MD
United States, California
Children's Hospital of Los Angeles
Recruiting
Los Angeles, California, United States, 90027
Contact: Rima Jubran, MD rjubran@chla.usc.edu
Principal Investigator: Rima Jubran, MD
Valley Children's Healthcare
Not yet recruiting
Madera, California, United States, 93636
Contact: David Samuel, MD DSamuel@valleychildrens.org
Contact: Faisal Razzaqi, MD FRazzaqi@valleychildrens.org
Principal Investigator: David Samuel, MD
United States, Connecticut
Connecticut Children's Medical Center
Not yet recruiting
Hartford, Connecticut, United States, 06106
Contact: Andrea Orsey, MD aorsey@connecticutchildrens.org
Principal Investigator: Andrea Orsey, MD
United States, District of Columbia
Children's National Medical Center
Recruiting
Washington, District of Columbia, United States, 20010
Contact: Stephan Ladisch, MD sladisch@childrensnational.org
Contact: Jay Greenberg, MD jagreenb@childrensnational.org
United States, Maryland
Johns Hopkins University
Not yet recruiting
Baltimore, Maryland, United States, 21287
Contact: Elias Zambidis, MD EZambid1@jhmi.edu
Contact: Christine Pratilas, MD Cpratil1@jhmi.edu
United States, Massachusetts
Massachusetts General Hospital
Recruiting
Boston, Massachusetts, United States, 02114
Contact: Mary Huang, MD 617-726-2737 mshuang@partners.org
Principal Investigator: Mary Huang, MD
Dana Farber Cancer Institute
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Barbara Degar, MD 617-632-6801 bdegar@partners.org
Principal Investigator: Barbara Degar, MD
United States, Minnesota
Children's Minnesota
Recruiting
Minneapolis, Minnesota, United States, 55404
Contact: Michael Richards, MD Michael.richards@childrensmn.org
Contact: Nathan Gossai, MD nathan.gossai@childrensmn.org
United States, New Jersey
Hackensack University Medical Center
Recruiting
Hackensack, New Jersey, United States, 07601
Contact: Steven Diamond, MD Steven.Diamond@hackensackmeridian.org
Contact: Burton Appel, MD Burton.appel@hackensackmeridian.org
United States, New York
Cohen Children's Medical Center
Recruiting
New Hyde Park, New York, United States, 11040
Contact: Carolyn Fein Levy, MD clevy4@northwell.edu
Contact: Jeffery Lipton, MD jlipton@northwell.edu
Columbia University / Herbert Irving Cancer Center
Recruiting
New York, New York, United States, 10032
Contact: Maria Luis Sulis, MD mls95@cumc.columbia.edu
Contact: Julia Glade Bender, MD jg589@cumc.columbia.edu
Staten Island University Hospital
Recruiting
Staten Island, New York, United States, 10305
Contact: Sarah Vaiselbuh, MD 718-226-6435 svaiselbuh@nshs.edu
Principal Investigator: Sarah Vaiselbuh`, MD
SUNY Upstate Medical University
Recruiting
Syracuse, New York, United States, 13210
Contact: Melanie Comito, MD comitom@upstate.edu
Contact: Andrea Dvorak, MD dvoraka@upstate.edu
United States, Ohio
Cincinnati Children's Hospital Medical Center
Recruiting
Cincinnati, Ohio, United States, 45229
Contact: Michael Jordan, MD 513-636-1773 Michael.jordan@cchmc.org
Contact: Ashish Kumar, MD 513-803-1631 ashish.kumar@cchmc.org
United States, South Carolina
Medical Universtiy of South Carolina/Hollings Cancer Center
Not yet recruiting
Charleston, South Carolina, United States, 29425
Contact: Jacqueline Kraveka, DO 843-792-2957 kravekjm@musc.edu
Principal Investigator: Jacqueline Kraveka, DO
United States, Tennessee
St. Jude Children's Research Hospital
Recruiting
Memphis, Tennessee, United States, 38105
Contact: Patrick Campbell, MD patrick.campbell@stjude.org
Principal Investigator: Patrick Campbell, MD
United States, Washington
Providence Sacred Heart Children's Hospital
Recruiting
Spokane, Washington, United States, 99204
Contact: Stefanos Intzes, MD stefanos.intzes@providence.org
Contact: Judy Felgenhauer, MD judy.felgenhauer@providence.org 收起 <<
United States, California
... 展开 >>
Stanford University Medical Center
Palo Alto, California, United States, 94304
United States, Massachusetts
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
United States, Michigan
Children's Hospital of Michigan (Wayne State University)
Detroit, Michigan, United States, 48201
United States, Tennessee
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
United States, Texas
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Texas Children's Cancer Center
Houston, Texas, United States, 77030
United States, Washington
Seattle Children's Hospital
Seattle, Washington, United States, 98105 收起 <<
China, Guangdong
... 展开 >>
The First Affiliated Hospital of Sun Yat-Sen University
Recruiting
Guangzhou, Guangdong, China, 510080
Contact: Xue-Qun Luo, professor L-xuequn@126.com
Principal Investigator: Xue-Qun Luo, professor 收起 <<
United States, New Jersey
... 展开 >>
Jersey Shore University Medical Center
Neptune, New Jersey, United States, 07754
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903 收起 <<
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital
Recruiting
Boston, Massachusetts, United States, 02114
Contact: Philip Amrein, MD 617-726-8748 Amrein.Philip@mgh.harvard.edu
Principal Investigator: Philip Amrein, MD
Beth Israel Deaconess Medical Center
Recruiting
Boston, Massachusetts, United States, 02215
Contact: Malgotzata McMasters, MD 617-667-9920 mmcmaste@bidmc.harvard.edu
Principal Investigator: Malgorzata McMasters, MD
Dana Farber Cancer Institute
Not yet recruiting
Boston, Massachusetts, United States, 02215
Contact: Daniel DeAngelo, MD, Ph.D 617-632-2645 DDEANGELO@PARTNERS.ORG
Principal Investigator: Daniel DeAngelo, MD, Ph.D 收起 <<
United States, California
... 展开 >>
Rady Children's Hospital and Health Center
San Diego, California, United States, 92123
United States, Tennessee
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105 收起 <<
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115 收起 <<
United States, Arizona
... 展开 >>
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
United States, California
Miller Children's Hospital
Long Beach, California, United States, 90806
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
University of California San Francisco Medical Center-Parnassus
San Francisco, California, United States, 94143
United States, Florida
Nemours Children's Clinic-Jacksonville South
Jacksonville, Florida, United States, 32207
United States, Georgia
Children's Healthcare of Atlanta - Egleston
Atlanta, Georgia, United States, 30322
United States, Kentucky
University of Kentucky
Lexington, Kentucky, United States, 40536
Kosair Children's Hospital
Louisville, Kentucky, United States, 40202
United States, Michigan
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
United States, New York
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, United States, 11040
United States, North Carolina
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
United States, Ohio
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
United States, Oregon
Legacy Emanuel Children's Hospital
Portland, Oregon, United States, 97227
Legacy Emanuel Hospital and Health Center
Portland, Oregon, United States, 97227
United States, Pennsylvania
Children's Oncology Group
Philadelphia, Pennsylvania, United States, 19104
United States, Texas
Baylor College of Medicine
Houston, Texas, United States, 77030
Methodist Children's Hospital of South Texas
San Antonio, Texas, United States, 78229
Australia, Western Australia
Princess Margaret Hospital for Children
Perth, Western Australia, Australia, 6008
Canada, Ontario
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1 收起 <<
France
... 展开 >> French-Belgian-Swiss APL study group
Not yet recruiting
Multiple Locations, France
Contact: Pierre Fenaux, Prof. Dr. pierre.fenaux@avc.ap-hop-paris.fr
Contact: Lionel Ades, Dr. lionel.ades@sls.aphp.fr
Germany
AML-CG study group
Recruiting
Multiple Locations, Germany
Contact: Eva Lengfelder, Prof. Dr. Eva.Lengfelder@umm.de
AML-SG study group
Recruiting
Multiple Locations, Germany
Contact: Richard F. Schlenk, Prof. Dr. Richard.Schlenk@uniklinik-ulm.de
OSHO study group
Recruiting
Multiple Locations, Germany
Contact: Dietger Niederwieser, Prof. Dr. Dietger.Niederwieser@medizin.uni-leipzig.de
SAL study group
Recruiting
Multiple Locations, Germany
Contact: Uwe Platzbecker, Prof. Dr. +49 351 458 ext 3192 uwe.platzbecker@uniklinikum-dresden.de
Contact: Michaela Sauer +49 351 458 ext 3192 michaela.sauer@uniklinikum-dresden.de
Italy
GIMEMA study group
Not yet recruiting
Multiple Locations, Italy
Contact: Francesco Lo-Coco, Prof. Dr. Francesco.lo.coco@uniroma2.it
Contact: Fabio Efficace, Dr. f.efficace@gimema.it
Netherlands
HOVON study group
Not yet recruiting
Multiple Locations, Netherlands
Contact: Edo Vellenga, Prof. Dr. e.vellenga@umcg.nl
Spain
PETHEMA study group
Not yet recruiting
Multiple Locations, Spain
Contact: Miguel A. Sanz, Prof. Dr. sanz_mig@gva.es
Contact: Pau Montesinos, Prof. Dr. montesinos_pau@gva.es 收起 <<
United States, California
... 展开 >>
Children's Hospital Los Angeles
Recruiting
Los Angeles, California, United States, 90027
Contact: Paul Gaynon, MD 323-361-4110 pgaynon@chla.usc.edu
Principal Investigator: Paul Gaynon, MD
Children's Hospital of Orange County
Recruiting
Orange, California, United States, 92868
Contact: Ivan Kirov, MD 714-997-3000 ikirov@choc.org
Principal Investigator: Ivan Kirov, MD
Lucile Packard Children's Hospital Stanford University
Recruiting
Palo Alto, California, United States, 94304
Contact: Norman J. Lacayo, MD 650-497-8953 lacayon@stanford.edu
Principal Investigator: Norman J. Lacayo, MD
Rady Children's Hospital and Health Center
Recruiting
San Diego, California, United States, 92123
Contact: Deborah Schiff, MD 858-966-5983 dschiff@chsd.org
Principal Investigator: Deborah Schiff, MD
United States, Minnesota
Children's Hospital and Clinics of Minnesota
Recruiting
Minneapolis, Minnesota, United States, 55102
Contact: Michael Richards, MD 612-813-5193 Michael.richards@childrensmn.org
Principal Investigator: Michael Richards, MD
United States, North Carolina
St. Jude Affiliate-Charlotte
Recruiting
Charlotte, North Carolina, United States, 28204
Contact: Christine Bolen, MD 704-384-1900 cybolen@novanthealth.org
Principal Investigator: Christine Bolen, MD
United States, Ohio
Cincinnati Children's Hospital
Recruiting
Cincinnati, Ohio, United States, 45229
Contact: Erin Breese, MD, PhD 513-636-2799 erin.breese@cchmc.org
Principal Investigator: Erin Breese, MD, PhD
Rainbow Babies & Children's Hospital
Recruiting
Cleveland, Ohio, United States, 44106
Contact: Yousif Matloub, MD 216-844-5437 yousif.matloub@uhhospitals.org
Principal Investigator: Yousif Matloub, MD
United States, Oregon
Oregon Health and Science University
Recruiting
Portland, Oregon, United States, 97239
Contact: Bill Chang, MD 503-494-1080 changb@ohsu.edu
Principal Investigator: Bill Chang, MD
United States, Tennessee
St. Jude Children's Research Hospital
Recruiting
Memphis, Tennessee, United States, 38105
Contact: Tanja A. Gruber, MD, PhD 866-278-5833 tanja.gruber@stjude.org
Contact: Referral Office 866-278-5833 referralinfo@stjude.org
Principal Investigator: Tanja A. Gruber, MD, PhD
United States, Virginia
Children's Hospital of the King's Daughters (CHKD)
Recruiting
Norfolk, Virginia, United States, 23507
Contact: Eric Lowe, MD 757-668-7243 eric.lowe@chkd.org
Principal Investigator: Eric Lowe, MD
Canada, Alberta
Alberta Children's Hospital
Recruiting
Calgary, Alberta, Canada, T3A 6A8
Contact: Victor A. Lewis, MD 403-220-6898 victor.lewis@ahs.ca
Principal Investigator: Victor A. Lewis, MD
Stollery Children's Hospital
Recruiting
Edmonton, Alberta, Canada, T6G 2B7
Contact: Sunil Desai, M.B.Ch.B., FRCP(c) 780-248-5415 sunil.desai@ahs.ca
Principal Investigator: Sunil Desai, M.B.Ch.B., FRCP(c)
Canada, British Columbia
Children's & Women's Health Centre of British Columbia
Recruiting
Vancouver, British Columbia, Canada, V6H 3V4
Contact: Kirk R. Schultz, MD 604-875-2345 ext 6477 kschultz@mail.ubc.ca
Principal Investigator: Kirk R. Schultz, MD
Canada, Ontario
McMaster Children's Hospital at Hamilton Health Sciences
Recruiting
Hamilton, Ontario, Canada, L85 4J9
Contact: Uma Athale, MD 905-521-2100 ext 73376 athaleu@mcmaster.ca
Principal Investigator: Uma Athale, MD
Canada, Quebec
The Montreal Children's Hospital (MUHC-McGill)
Recruiting
Montreal, Quebec, Canada, H4A 3J1
Contact: Catherine Vezina, MD 514-412-4445 catherine.vezina@muhc.mcgill.ca
Principal Investigator: Catherine Vezina, MD
Centre Hospitalier Universitaire Sainte-Justine
Recruiting
Montreal, Quebec, Canada, HcT 1C5
Contact: Henrique Bittencourt, MD 514-345-4931 henrique.bittencourt.hsj@ssss.gouv.qc.ca
Contact: Yvan Samson yvan.samson@umontreal.ca
Principal Investigator: Henrique Bittencourt, MD
Centre Hospitalier Universitaire de Quebec
Recruiting
Québec, Quebec, Canada, G1V 4G2
Contact: Bruno Michon, MD 418-525-4444 bruno.michon@mail.chuq.qc.ca
Principal Investigator: Bruno Michon, MD 收起 <<
United States, California
... 展开 >>
Rady Children's Hospital and Health Center
Completed
San Diego, California, United States, 92123
United States, Tennessee
St. Jude Children's Research Hospital
Recruiting
Memphis, Tennessee, United States, 38105
Contact: Sima Jeha, MD 866-278-5833 referralinfo@stjude.org
Principal Investigator: Sima Jeha, MD
United States, Texas
Cook Children's Medical Center
Recruiting
Fort Worth, Texas, United States, 76104
Contact: Kenneth M. Heym, MD 682-885-4007
Principal Investigator: Kenneth M. Heym, MD 收起 <<
United States, California
... 展开 >>
Rady Children's Hospital San Diego
San Diego, California, United States, 92123
United States, Tennessee
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105 收起 <<
Poland
... 展开 >> PALG
Lodz, Poland
Spain
Hospital General
Albacete, Spain
Hospital general
Alicante, Spain
Hospital germans Trias i Pujol
Badalona, Spain
Hospital Clinic
Barcelona, Spain
Hospital de Sant Pau
Barcelona, Spain
Institut Català d'Oncologái
Barcelona, Spain
Basurtuko Ospitalea
Bilbao, Spain
Hospital general
Castellon, Spain
Hospital de Fuenlabrada
Fuenlabrada, Spain
Hospital "Dr. Trueta"
Gerona, Spain
Hospital de Jerez de la Frontera
Jerez de la Frontera, Spain
Hospital Juan Canalejo
La Coruña, Spain
Hospital Insular de las Palmas
Las Palmas de Gran Canaria, Spain
Complejo Hospitalario León
Leon, Spain
Complexo Hospitalario Xeral-Calde
Lugo, Spain
Hospital 12 de Octubre
Madrid, Spain
Hospital Clínico San Carlos
Madrid, Spain
Hospital Puerta de Hierro
Madrid, Spain
Hospital Reina Sofia
Madrid, Spain
Hospital San Pedro de Alcántara
Madrid, Spain
Hospital Severo Ochoa
Madrid, Spain
Hospital Sta. Maria del Rosell
Murcia, Spain
H. Carlos Haya
Málaga, Spain
H. Universitario Virgen de la Victoria
Málaga, Spain
Hospital Central de Asturias
Oviedo, Spain
Hospital Dr Negrín
Palma de Gran Canaria, Spain
Hospital de Navarra
Pamplona, Spain
Hospital de Montecelo
Pontevedra, Spain
Hospital Clínico Universitario
Salamanca, Spain
Hospital de Cruces
Santander, Spain
Hospital de Santiago de Compostela
Santiago de Compostela, Spain
H.U. Virgen del Rocio
Sevilla, Spain
Hospital Joan XXIII
Tarragona, Spain
Hospital Dr. Peset
Valencia, Spain
Hospital general
Valencia, Spain
Hospital La Fe
Valencia, Spain
Hospital Clínico de Valladolid
Valladolid, Spain
Hospital Txagorritxu
Vitoria, Spain
Hospital Virgen de la Concha
Zamora, Spain
Hospital Clínico Universitario Lozano Blesa
Zaragoza, Spain
Uruguay
Hospital Maciel
Montevideo, Uruguay 收起 <<
Korea, Republic of
... 展开 >>
Severance Hospital
Seoul, Korea, Republic of, 03722
Ewha Medical Research Institute
Seoul, Korea, Republic of
Gangnam Severance Hospital
Seoul, Korea, Republic of
Korea University Hospital
Seoul, Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of 收起 <<
United States, Massachusetts
... 展开 >>
Boston Medical Center
Recruiting
Boston, Massachusetts, United States, 02118
Contact: Sherida S. Padilla, MD 617-638-6527 sherida.padilla@bmc.org
Contact: Jill Harrington, MD 617-638-8000 jill.harrington@bmc.org
Principal Investigator: Sharmeel K Wasan, MD 收起 <<
Spain
... 展开 >> Hospital Germans Trias i Pujol
Recruiting
Badalona, Spain
Contact: Josep Mª Ribera, Dr jribera@iconcologia.net
Hospital Clinic
Recruiting
Barcelona, Spain, 08036
Contact: Jordi Esteve, Dr JESTEVE@clinic.ub.es
Hospital Universitario Vall d'Hebron
Recruiting
Barcelona, Spain
Contact: Pere Barba, Dr pebarba@vhebron.net
Hospital 12 de Octubre
Recruiting
Madrid, Spain
Contact: Mª Pilar Martinez Sánchez, Dr mpmartinezs.hdoc@salud.madrid.org
Hospital Virgen de la Victoria
Recruiting
Málaga, Spain
Contact: Mª José Moreno, Dr mjmorenorico@hotmail.com
Hospital Clinico Universitario de Salamanca
Recruiting
Salamanca, Spain
Contact: Jesús Maria Hernández Rivas, Dr jmhr@usal.es
Hospital Marques de Valdecilla
Recruiting
Santander, Spain
Contact: Mª Aranzazu Bermudez, Dr mbermudez@humv.es
C H Santiago de Compostela
Recruiting
Santiago de Compostela, Spain
Contact: Natalia Alonso, Dr natalia.alonso.vence@sergas.es
Hospital Virgen del Rocio
Recruiting
Sevilla, Spain
Contact: Jose Gonzalez Campos, Dr jose.gonzalez.sspa@juntadeandalucia.es
Hospital Clinico de Valencia
Recruiting
Valencia, Spain
Contact: Mª del Mar Tormo, Dr tormo_mar@gva.es
Hospital La Fe
Recruiting
Valencia, Spain
Contact: Pau Montesinos, Dr montesinos_pau@gva.es 收起 <<
United Kingdom
... 展开 >> Department of Biochemistry, City Hospital
Recruiting
Birmingham, West Midlands, United Kingdom
Contact: Jonathan Berg, FRCPath 01215075345 jonathanberg@nhs.net
Contact: Jenna Waldron, FRCPath 01215075025 jenna.waldron@nhs.net 收起 <<
United States, Texas
... 展开 >>
University of Texas MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Clinical Research Operations ejabbour@mdanderson.org 收起 <<
United States, Illinois
... 展开 >>
Cancer and Leukemia Group B
Chicago, Illinois, United States, 60606
United States, North Carolina
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
Israel
... 展开 >> Department of Gastroenterology and Liver Diseases, Tel-Aviv Soursky Medical Center
Not yet recruiting
Tel-Aviv, Israel, 64239
Contact: Erez F Scapa, M.D. 972-52-4266345 erezs@tasmc.health.gov.il
Principal Investigator: Erez F Scapa, M.D. 收起 <<
Denmark
... 展开 >> Department of Pediatrics, Rigshospitalet
Copenhagen, Denmark
Finland
Helsinki University Hospital
Helsinki, Finland
Iceland
University Hospital
Reykjavik, Iceland
Norway
Trondheim University Hospital
Trondheim, Norway
Sweden
Department of Pediatrics, Drottning Sylvias Pediatric Hospital
Gothenburg, Sweden
NOPHO nordic organisation for pediatric onology
Stockholm, Sweden 收起 <<
Denmark
... 展开 >> Department of Pediatrics, Rigshospitalet
Copenhagen, Denmark
Department of Pediatrics, University Hospital
Odense, Denmark
Sweden
Department of Pediatrics, Drottning Sylvias Pediatric Hospital
Gothenburg, Sweden 收起 <<
Terminated(Sponsor withdrew su... 展开 >>pport of study due to reorganization and project prioritization) 收起 <<
-
Israel
... 展开 >> Ha'emek Medical Center
Afula, Israel
Bnai Zion Hospital
Haifa, Israel
Rambam Medical Center
Haifa, Israel
Hadassah Medical Center
Jerusalem, Israel
Shaarei Tzedek Medical Center
Jerusalem, Israel
Meir Medical Center
Kfar Saba, Israel
Holy Family Hospital
Nazareth, Israel
Kaplan Medical Center
Rehovot, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Sheba Medical Center
Tel Hashomer, Israel
Assaf Harofeh
Zerifin, Israel 收起 <<
United States, Missouri
... 展开 >>
The Children's Mercy Hospital
Recruiting
Kansas City, Missouri, United States, 64108
Contact: Michael Venneman 816-234-3059 mvenneman@cmh.edu
Contact: Kathleen A Neville, MD;MS 816-234-3059 kaneville@cmh.edu
Principal Investigator: Kathleen A Neville, MD:MS 收起 <<
United States, California
... 展开 >>
USC Norris Comprehensive Cancer Center
Recruiting
Los Angeles, California, United States, 90033
Contact: Howard Liebman, Dr 323-865-3950 liebman_h@med.usc.edu
United States, Massachusetts
Massachusetts General Hospital
Recruiting
Boston, Massachusetts, United States, 02114
Contact: Jan Sjoquist 617-726-0153 jsjoquist@mgh.harvard.edu
Contact: David Kuter, MD 617-726-8033 dkuter@partners.org
Principal Investigator: David Kuter, MD
United States, Michigan
Michigan Center of Medical Research
Recruiting
Farmington Hills, Michigan, United States, 48334
Contact: Tallat Mahmood, Dr 248-747-4383 Tallat.mahmood@michmer.com
United States, New York
Weil-Cornell Medical College
Active, not recruiting
New York, New York, United States, 10065
United States, Ohio
Gabrail Cancer Center
Completed
Canton, Ohio, United States, 44718
Cleveland Clinic Foundation
Completed
Cleveland, Ohio, United States, 44195
United Kingdom
Aberdeen Royal Infirmary
Recruiting
Aberdeen, AB, United Kingdom, AB25 27N
Contact: Henry Watson, Prof. +44 (0) 1224 693119 henrywatson@nhs.net
Principal Investigator: Henry Watson, MD
Leicester Royal Infirmary
Not yet recruiting
Leicester, Leichester, United Kingdom, LE1 5WW
Contact: Mamta Garg, MD +44 (0) 1162 586611 mamta.garg@uhl-tr.nhs.uk
Principal Investigator: Mamta Garg, MD
Queen Elizabeth Hospital
Recruiting
Birmingham, United Kingdom, B15 2TH
Contact: Charles Percy, MD +44 (0) 121 3714898 Charles.Percy@uhb.nhs.uk
Principal Investigator: Charles Percy, MD
Glasgow Royal Infirmary
Recruiting
Glasgow, United Kingdom, G4 0SF
Contact: Catherine Bagot, MD +44 (0) 1412114000 Catherine.Bagot@ggc.scot.nhs.uk
Principal Investigator: Catherine Bagot, MD
Norfolk and Norwich Hospital
Recruiting
Norwich, United Kingdom, NR4 7UY
Contact: Lyall Hamish, MD +44 (0) 1603287866 Hamish.Lyall@nnuh.nhs.uk
Principal Investigator: Lyall Hamish, MD 收起 <<
United States, Washington
... 展开 >>
Fred Hutch/University of Washington Cancer Consortium
Recruiting
Seattle, Washington, United States, 98109
Contact: Pamela S. Becker 206-616-1589 pbecker@u.washington.edu
Principal Investigator: Pamela S. Becker 收起 <<
United States, Wisconsin
... 展开 >>
University of Wisconsin Digestive Health Center
Recruiting
Madison, Wisconsin, United States, 53705
Contact: Lindsey Leudke leluedke@medicine.wisc.edu
Contact: Freddy Caldera fcaldera@medicine.wisc.edu
Principal Investigator: Freddy Caldera, DO 收起 <<
Korea, Republic of
... 展开 >>
Yonsei University: Wonju Christian Hospital
Wonju, Kangwon-do, Korea, Republic of, 220-701
Kosin University Gospel Hospital
Busan, Korea, Republic of
Soonchunhyang University
Cheonan, Korea, Republic of
Keimyung University; Dongsan Hospital
Daegu, Korea, Republic of
Wonkwang University
Iksan, Korea, Republic of
Kyung Hee University Hospital
Seoul, Korea, Republic of, 130-702
Asan Medical Center
Seoul, Korea, Republic of
Chung-Ang University
Seoul, Korea, Republic of
Ewha Womans University
Seoul, Korea, Republic of
Inje University; Seoul Paik Hospital
Seoul, Korea, Republic of
Konkuk University Hospital
Seoul, Korea, Republic of
Korea University; Ansan Hospital
Seoul, Korea, Republic of
Yonsei University; Severance Hospital
Seoul, Korea, Republic of
Seoul National University Hospital
Seul, Korea, Republic of
The Catholic University of Korea; St. Vincent's Hospital
Suwon, Korea, Republic of 收起 <<
United States, Massachusetts
... 展开 >>
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Massachusetts General Hospital
Boston, Massachusetts, United States, 02115
United States, New York
University Of Columbia Medical Center
New York, New York, United States
Canada, Manitoba
Manitoba Blood & Marrow Transplant Program CancerCare Manitoba
Winnipeg, Manitoba, Canada
Canada, Ontario
McMaster University Medical Center
Hamilton, Ontario, Canada
Queen's University
Kingston, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Canada, Quebec
Hospital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Royal Victoria Hospital
Montreal, Quebec, Canada
Canada, Saskatchewan
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Canada
Queen Elizabeth II
Halifax, Canada 收起 <<
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Children's Hospital of Boston
Boston, Massachusetts, United States, 02115
Beth Isreal Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
United States, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
New York, New York, United States, 10032
United States, Ohio
Ohio State University Medical Center
Columbus, Ohio, United States, 43210
United States, Utah
LDS Hospital
Salt Lake City, Utah, United States, 84143
Canada, British Columbia
Vancouver Cancer Center
Vancouver, British Columbia, Canada, V5Z 4E6
Canada, Manitoba
Cancer Care Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Canada, New Brunswick
The Moncton Hospital
Moncton, New Brunswick, Canada
Canada, Nova Scotia
QEII, Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Quebec
Hopital Charles LeMoyne
Greenfield Park, Quebec, Canada, J4V 2H1
Hopital Maisonneuve Rosemont
Montreal, Quebec, Canada, H1T 2M4
Hopital Notre-Dame
Montreal, Quebec, Canada
McGill University Department of Oncology
Montreal, Quebec, Canada 收起 <<
Belgium
... 展开 >> Ziekenhuis Netwerk Antwerpen Middelheim
Antwerp, Belgium, 2020
Hopital Universitaire Des Enfants Reine Fabiola
Brussels, Belgium, 1020
Academisch Ziekenhuis der Vrije Universiteit Brussel
Brussels, Belgium, 1090
Ghent University
Ghent, Belgium, B-9000
Universitair Ziekenhuis Gent
Ghent, Belgium, B-9000
U.Z. Gasthuisberg
Leuven, Belgium, B-3000
Centre Hospitalier Regional de la Citadelle
Liege, Belgium, 4000
Clinique de l'Esperance
Montegnee, Belgium, 4420
France
Centre Hospitalier Regional et Universitaire d'Angers
Angers, France, 49033
CHR de Besancon - Hopital Saint-Jacques
Besancon, France, 25030
CHU de Caen
Caen, France, 14033
CHU de Grenoble - Hopital de la Tronche
Grenoble, France, 38043
Hopital Debrousse
Lyon, France, 69322
Hopital Arnaud de Villeneuve
Montpellier, France, 34059
CHR Hotel Dieu
Nantes, France, 44035
Hopital de l'Archet CHU de Nice
Nice, France, F-06202
CHU - Hopital Robert Debre
Paris, France, 75019
Hopital Jean Bernard
Poitiers, France, 86021
Hopital Americain
Reims, France, 51092
Hopital Universitaire Hautepierre
Strasbourg, France, 67098
Hopital des Enfants
Toulouse, France, 31026
Portugal
Hospital Escolar San Joao
Porto, Portugal, 4200
Instituto Portugues de Oncologia Centro do Porto, SA
Porto, Portugal, 4200 收起 <<
United States, California
... 展开 >>
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027-0700
Lucile Packard Children's Hospital at Stanford
Palo Alto, California, United States, 94304
UCSF Comprehensive Cancer Center
San Francisco, California, United States, 94143-0128
United States, District of Columbia
Children's National Medical Center
Washington, District of Columbia, United States, 20010-2970
United States, Illinois
Saint Jude Midwest Affiliate
Peoria, Illinois, United States, 61637
United States, Indiana
Indiana University Cancer Center
Indianapolis, Indiana, United States, 46202-5289
United States, Massachusetts
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
United States, Minnesota
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216-4505
United States, New York
Albert Einstein Clinical Cancer Center
Bronx, New York, United States, 10461
Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
State University of New York - Upstate Medical University
Syracuse, New York, United States, 13210
United States, Ohio
Children's Hospital Medical Center - Cincinnati
Cincinnati, Ohio, United States, 45229-3039
United States, Oregon
Doernbecher Children's Hospital
Portland, Oregon, United States, 97201-3098
United States, Pennsylvania
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Texas
University of Texas Medical Branch
Galveston, Texas, United States, 77555-0361
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030-4009
Baylor College of Medicine
Houston, Texas, United States, 77030
United States, Washington
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, United States, 98105 收起 <<
United States, California
... 展开 >>
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, United States, 90095-1678
Stanford Cancer Center at Stanford University Medical Center
Stanford, California, United States, 94305-5750
United States, Georgia
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States, 30322
United States, New York
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
New York Medical College
Valhalla, New York, United States, 10595
United States, North Carolina
Duke Comprehensive Cancer Center
Durham, North Carolina, United States, 27710
United States, Ohio
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195 收起 <<
Japan
... 展开 >> Department of Hematology, Nagoya University Graduate School of Medicine
Recruiting
Nagoya, Japan, 466-8550
Contact: Fumihiko Hayakawa, MD bun-hy@med.nagoya-u.ac.jp
Principal Investigator: Fumihiko Hayakawa, MD 收起 <<
United States, Maryland
... 展开 >>
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
Bethesda, Maryland, United States, 20892-1182
Egypt
National Cancer Institute of Egypt
Cairo, Egypt
India
Kidwai Memorial Institute of Oncology
Bangalore, India, 560029
Cancer Institute (W.I.A.)
Madras, India, 600020
Tata Memorial Centre
Mumbai, India, 400012 收起 <<
Japan
... 展开 >> Department of Hematology, Nagoya University Graduate School of Medicine
Recruiting
Nagoya, Japan, 466-8550
Contact: Fumihiko Hayakawa, MD bun-hy@med.nagoya-u.ac.jp
Principal Investigator: Fumihiko Hayakawa, MD 收起 <<
Drug/Agent Toxicity by Tissue/... 展开 >>Organ
Leukemia 收起 <<
Phase 3
Active, not recruiting
June 2019
United States, Massachusetts
... 展开 >>
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115
United States, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine
Bronx, New York, United States, 10461
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
New York, New York, United States, 10032
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States, 14642
United States, Rhode Island
Hasbro Children's Hospital
Providence, Rhode Island, United States, 02903
United States, Virginia
INOVA Fairfax Hospital
Fairfax, Virginia, United States, 22031
Canada, Ontario
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8N 3Z5
Canada, Quebec
Hopital Sainte Justine
Montreal, Quebec, Canada, H3T 1C5
Centre de Recherche du Centre Hospitalier de l'Universite Laval
Sainte Foy, Quebec, Canada, GIV 4G2
Puerto Rico
San Jorge Children's Hospital
Santurce, Puerto Rico, 00912 收起 <<
United States, Maryland
... 展开 >>
Pediatric Oncology Branch
Bethesda, Maryland, United States, 20892
United States, Texas
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, United States, 79106
India
Kidwai Memorial Institute of Oncology
Bangalore, India, 560029
Cancer Institute (W.I.A.)
Madras, India, 600020
Tata Memorial Centre
Mumbai, India, 400012
All-India Institute of Medical Sciences
New Delhi, India, 110029 收起 <<
Terminated(Withdrawn due to an... 展开 >> excess of toxic deaths) 收起 <<
-
Germany
... 展开 >> Kinderklinik
Giessen, Germany, D-35385
Ireland
Our Lady's Hospital for Sick Children Crumlin
Dublin, Ireland, 12
United Kingdom
Birmingham Children's Hospital
Birmingham, England, United Kingdom, B4 6NH
Institute of Child Health at University of Bristol
Bristol, England, United Kingdom, BS2 8AE
Addenbrooke's Hospital
Cambridge, England, United Kingdom, CB2 2QQ
Leeds Cancer Centre at St. James's University Hospital
Leeds, England, United Kingdom, LS9 7TF
Leicester Royal Infirmary
Leicester, England, United Kingdom, LE1 5WW
Royal Liverpool Children's Hospital, Alder Hey
Liverpool, England, United Kingdom, L12 2AP
Royal London Hospital
London, England, United Kingdom, E1 1BB
Great Ormond Street Hospital for Children
London, England, United Kingdom, WC1N 3JH
Royal Manchester Children's Hospital
Manchester, England, United Kingdom, M27 4HA
Sir James Spence Institute of Child Health
Newcastle-Upon-Tyne, England, United Kingdom, NE1 4LP
Queen's Medical Centre
Nottingham, England, United Kingdom, NG7 2UH
Oxford Radcliffe Hospital
Oxford, England, United Kingdom, 0X3 9DU
Children's Hospital - Sheffield
Sheffield, England, United Kingdom, S10 2TH
Southampton General Hospital
Southampton, England, United Kingdom, SO16 6YD
Royal Marsden - Surrey
Sutton, England, United Kingdom, SM2 5PT
Royal Belfast Hospital for Sick Children
Belfast, Northern Ireland, United Kingdom, BT12 6BE
Royal Aberdeen Children's Hospital
Aberdeen, Scotland, United Kingdom, AB25 2ZG
Royal Hospital for Sick Children
Edinburgh, Scotland, United Kingdom, EH9 1LF
Royal Hospital for Sick Children
Glasgow, Scotland, United Kingdom, G3 8SJ
Childrens Hospital for Wales
Cardiff, Wales, United Kingdom, CF14 4XW 收起 <<
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