Investigate the mechanism of DHA and AA release under ATP stimulation, finding that DDA (2',3'-Dideoxyadenosine) almost completely blocks ATP-induced AA release.
Br J Pharmacol. 2003 Jul;139(5):1014-22
Human bronchial epithelial cells (16HBE14o- cell line)
Guinea-pig thalamic slice relay neurones of the dorsal lateral geniculate nucleus (LGND)
50-100 μM
2',3'-Dideoxyadenosine mimicked the decrease in Ih evoked by A1 receptor activation through inhibition of adenylyl cyclase activity.
J Physiol. 1992 Feb;447:729-53
Rat ventral tegmental area neurons
100 μM
2',3'-Dideoxyadenosine, an adenylyl cyclase inhibitor, was used to study its effect on Ih current. Results showed that 2',3'-dideoxyadenosine did not affect Ih current nor alter dopamine's inhibition of Ih.
J Physiol. 1993 Mar;462:753-64
TM3 cells
100 μM
20 days
Protect cells from viral infection and maintain their immune reactivity.
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2033-7
ATH8 cells
50 μM
30 days
Inhibit HTLV-III/LAV DNA synthesis and mRNA expression, protecting cells from viral infection.
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2033-7
2',3'-Dideoxyadenosine/2',3'-二脱氧腺苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Swiss albino mice
Systemic infection model
Oral or subcutaneous
12 to 219 mg/kg
Treatment immediately, 5, 24, 29, 48, and 72 hours post-infection, observed for 14 days
Evaluate the antibacterial activity of DDA in a mouse systemic infection model, showing protective effects against multiple strains at doses well below toxic levels.
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