There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
α-Lipoic Acid, a naturally occurring substance, has many biological activities[1]. In vitro studies, α-lipoic acid could increase the level of PON1 and PON3 protein, as well as regulate their mRNA expression in HepG2 cells[2]. Besides this, it was found that α-lipoic acid had good antioxidant activity in C2C12 myotubes, through upregulating catalase expression[3]. In vivo studies, α-lipoic acid has the ability of protecting the cortical neurons against the high-fat diet-induced cerebral damage in mice, by inhibiting the oxidative stress and inflammatory reactions[4]. In addition, α-lipoic acid could contribute to the mitigation of α-cypermethrin-induced toxicity in cerebellum of treated rats[5].
α-Lipoic Acid/α-硫辛酸 细胞实验
Cell Line
Concentration
Treated Time
Description
References
AR42J cells
5 µM
1, 2, and 3 hours
Α-Lipoic acid increased the protein levels of PPAR-γ and its target genes HO-1 and catalase.
Mol Med Rep. 2022 Aug;26(2):264
LMP (CD34pos, CD45RApos, CD133pos)
100 µM
10 days
To evaluate the effect of ALA on the expansion of LMP cells, results showed that ALA significantly increased the expansion of LMP cells.
Biomolecules. 2022 Mar 11;12(3):431
EMP (CD34pos, CD45RAneg, CD133low)
100 µM
10 days
To evaluate the effect of ALA on the expansion of EMP cells, results showed that ALA significantly increased the expansion of EMP cells.
Biomolecules. 2022 Mar 11;12(3):431
SSPB CD34 positive cells
30 to 250 µM
10 days
To evaluate the effect of ALA on the ex vivo expansion of SSPB CD34 positive cells, results showed that ALA decreased total cell expansion in a dose-dependent manner but significantly increased the expansion of CD34 positive cells.
Biomolecules. 2022 Mar 11;12(3):431
Human colorectal adenocarcinoma cells Caco-2
50, 150, 300 µM
12hours
ALA significantly promoted Caco-2 cell migration, increased the expression of mucosal tight junction factors ZO-1 and OCLN, and accelerated cell injury repair.
Mediators Inflamm. 2022 Jun 7;2022:1894379
Human colonic epithelial cells NCM460
50, 150, 300 µM
12hours and 24hours
ALA significantly promoted NCM460 cell migration, increased the expression of mucosal tight junction factors ZO-1 and OCLN, and accelerated cell injury repair.
Mediators Inflamm. 2022 Jun 7;2022:1894379
MC3T3-E1
100 nM
2 days
To assess the effect of α-LA on PCa-mediated osteoblast differentiation, results showed that α-LA significantly inhibited PCa-mediated osteoblast differentiation.
Sci Rep. 2024 Feb 22;14(1):4404
LMH cells
10 µM As2O3 + 25 µM LA
24 hours
To evaluate the protective effect of α-lipoic acid on arsenic-induced hepatocyte injury, results showed that α-lipoic acid significantly alleviated the decline in cell proliferation rate induced by arsenic.
Adv Sci (Weinh). 2025 Mar;12(11):e2413255
HEI-OC1 cells
500 µM
24 hours
To investigate the protective effect of α-LA against cisplatin-induced ototoxicity, results showed that α-LA pretreatment significantly improved cell viability.
Int J Mol Sci. 2022 Sep 19;23(18):10981
3T3-L1 preadipocytes
5 µM, 25 µM, 100 µM
24 hours, 48 hours, 10 d, 17 d
Α-Lipoic acid ameliorated the morphology of Atp7a−/− cells similarly to the copper chelator BCS but through a different mechanism. LA did not decrease intracellular copper levels but instead increased selenium levels and selenoprotein expression, improving the cellular redox environment.
Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2305961120
AR42J cells
2 or 5 µM
45 minutes
Α-Lipoic acid dose-dependently inhibited the cerulein/resistin-induced increase in intracellular ROS levels and IL-6 expression levels.
Mol Med Rep. 2022 Aug;26(2):264
C4-2B
50, 100, 200, 300, 500, 1000, 2000 µM
48 hours
To assess the impact of α-LA on cell viability, results showed that α-LA treatment significantly reduced cell viability in a dose-dependent manner.
Sci Rep. 2024 Feb 22;14(1):4404
22Rv1
50, 100, 200, 300, 500, 1000, 2000 µM
48 hours
To assess the impact of α-LA on cell viability, results showed that α-LA treatment significantly reduced cell viability in a dose-dependent manner.
Sci Rep. 2024 Feb 22;14(1):4404
BMMs
100 nM
7 days
To assess the effect of α-LA on PCa-mediated osteoclast differentiation, results showed that α-LA significantly inhibited PCa-mediated osteoclast differentiation.
Sci Rep. 2024 Feb 22;14(1):4404
HSC/MPP (CD34pos, CD45RAneg, CD133pos)
100 µM
7 days
To evaluate the effect of ALA on the expansion of HSC/MPP cells, results showed that ALA significantly increased the expansion of HSC/MPP cells.
Biomolecules. 2022 Mar 11;12(3):431
α-Lipoic Acid/α-硫辛酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Normal diet vs. 0.2% α-lipoic acid supplemented diet model
Oral (dietary addition)
0.2% dietary supplementation
Ad libitum for 5 weeks
Investigated the effect of α-lipoic acid on hepatic lipid deposition, showing reduced plasma triglyceride levels, hepatic triglyceride content, downregulated FASN and FABP1 protein expression, and upregulated p-HSL protein expression.
Nutrients. 2021 Jul 8;13(7):2331
Drosophila melanogaster
Aged Drosophila midgut model
Oral
0.5 mM
Started at day 26 and lasted for 14 days
ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the decline of intestinal function in aged Drosophila, extending their lifespan. ALA reversed age-associated ISC dysfunction by promoting the activation of the endocytosis–autophagy network.
EMBO Rep. 2020 Aug 5;21(8):e49583
Rats
High fat diet-induced obesity model
Oral gavage
100 mg/kg
Daily for 4 weeks
ALA attenuated the hepatic and renal complications induced by obesity in rats through reducing oxidative stress and inflammation.
To study the effects of α-lipoic acid on metabolites of the methionine pathway. Results showed a massive increase in serum S-adenosylhomocysteine (SAH) and marked depletion of liver S-adenosylmethionine (SAM) after α-lipoic acid injection.
Free Radic Biol Med. 2009 Oct 15;47(8):1147-53
Hailan Brown chickens
Arsenic-induced liver injury model
Feed additive
27.27 mg/kg As2O3 + 200/400 mg/kg LA
Continued for 20 or 32 weeks
To evaluate the protective effect of α-lipoic acid on arsenic-induced liver injury, results showed that α-lipoic acid significantly alleviated arsenic-induced liver function damage and lipid metabolism disorders.
Adv Sci (Weinh). 2025 Mar;12(11):e2413255
Wistar rats
Metabolic dysfunction-associated steatotic liver disease (MASLD) model
Intragastric administration
30 mg/kg
Once daily for eight weeks
To evaluate the protective effect of α-lipoic acid on hepatic sphingolipid metabolism and insulin signaling transduction in MASLD rats. Results showed that α-LA decreased sphinganine, dihydroceramide, and sphingosine levels, increased ceramide level, and activated the PI3K/Akt/mTOR pathway.
Nutrients. 2024 May 16;16(10):1501
Sprague-Dawley rats
Incisional pain model
Intraperitoneal injection
60 mg/kg and 120 mg/kg
Single injection or repeated injections (three consecutive days before surgery and on POD 0, POD 1, and POD 2 after surgery)
To evaluate the analgesic effects of ALA in a postsurgical pain model. Results showed that single and repeated intraperitoneal injections of ALA significantly reduced evoked mechanical hyperalgesia after surgery, and repeated preemptive injections effectively alleviated spontaneous postsurgical pain.
Channels (Austin). 2021 Dec;15(1):398-407
Wistar rats
Hypercaloric choline-deficient diet-induced NAFLD model
Dietary supplementation
61 mg/kg
Once daily for 8 weeks
To investigate the impact of α-lipoic acid on oxidative stress and lipid accumulation induced by a hypercaloric choline-deficient diet. Results showed that α-lipoic acid detains obesity development but exacerbates diet-induced oxidative stress and lipid accumulation in the liver.
To study the enantioselective pharmacokinetics of α-lipoic acid, it was found that the exposure of R-α-lipoic acid was higher than that of S-α-lipoic acid, and the enantioselectivity occurred in the absorption phase rather than the elimination phase.
United States, North Carolina
... 展开 >>
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
United States, North Carolina
... 展开 >>
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
Lebanon
... 展开 >> American University of Beirut Medical Center
Recruiting
Beirut, Lebanon
Contact: Johnny Awwad, MD 00961 1 350000 ext 5606 jawwad@aub.edu.lb 收起 <<
United States, North Carolina
... 展开 >>
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
United States, New Jersey
... 展开 >>
International Brain Research Foundation
Recruiting
Edison, New Jersey, United States, 08837
Contact: Philip Defina, PhD 732-494-7600 pdefina@ibrfinc.org
Principal Investigator: Philip Defina, PhD 收起 <<
United States, Georgia
... 展开 >>
Georgia Prevention Institute , Georgia Regents University
Recruiting
Augusta, Georgia, United States, 30912
Contact: Ryan Harris, PhD 706-721-5998 ryharris@gru.edu
Contact: Jacob Looney, BS 706 721-5483 jlooney@gru.edu
Principal Investigator: Ryan Harris, PhD 收起 <<
Impaired Glucose Tolerance
... 展开 >> Prediabetic State 收起 <<
Not Applicable
Completed
-
United States, Georgia
... 展开 >>
Grady Health System
Atlanta, Georgia, United States, 30303
Emory University Hospital
Atlanta, Georgia, United States, 30322 收起 <<
China, Jiangsu
... 展开 >> Jiangsu Provincial People's Hospital
Not yet recruiting
Nanjing, Jiangsu, China, 210029
Contact: Qi Wan 86 13770316989 qi_wan@126.com
Sub-Investigator: Jie Gong
Sub-Investigator: Wei Wang
Principal Investigator: Qi Wan
Sub-Investigator: Ping Gu
Affiliated Hospital of Nantong University
Not yet recruiting
Nantong, Jiangsu, China, 226001
Contact: Kaifu Ke 0513-85052569 kekaifu_nt@126.com
Sub-Investigator: Maohong Cao
Principal Investigator: Kaifu Ke
Sub-Investigator: Aihong Li
The Second Affiliated Hospital of Soochow University
Not yet recruiting
Suzhou, Jiangsu, China, 215004
Contact: Heqing Zhao 86 13004571960 zhao_heqing@163.com
Principal Investigator: Heqing Zhao
Sub-Investigator: Xia Zhang
Sub-Investigator: Weidong Hu
The First Affiliated Hospital of Soochow University
Not yet recruiting
Suzhou, Jiangsu, China, 215006
Contact: Wanli Dong 86 512 65223637 ext 8317 dwlsz@163.com
Principal Investigator: Wanli Dong
Sub-Investigator: Shouru Xue
Sub-Investigator: Xiaowei Hu
Sub-Investigator: Hongxia Wang
Wuxi No.2 People's Hospital
Not yet recruiting
Wuxi, Jiangsu, China, 214002
Contact: Yuenan Kong 86 051267727501 ext 3503 kkyynn2008@yahoo.cn
Principal Investigator: Yuenan Kong
Sub-Investigator: Wenzhuo Dai
Sub-Investigator: Tao Ma 收起 <<
United States, Pennsylvania
... 展开 >>
St. Christopher's Hospital for Children
Recruiting
Philadelphia, Pennsylvania, United States, 19134
Contact: Michael J Goldenthal, PhD 215-427-6786 michael.goldenthal@drexelmed.edu 收起 <<
Hypertension
... 展开 >>Diabetes Mellitus, Type 2 收起 <<
Phase 2
Completed
-
United States, California
... 展开 >>
Garden Grove, California, United States, 92844
La Mesa, California, United States, 91942
Northridge, California, United States, 91324
Riverside, California, United States, 92505
Tustin, California, United States, 92780
United States, Florida
Kissimmee, Florida, United States, 34741
Miami, Florida, United States, 33015
United States, Georgia
Macon, Georgia, United States, 31217
Tucker, Georgia, United States, 30084
United States, Maryland
Reisterstown, Maryland, United States, 21136
United States, Minnesota
Brooklyn Center, Minnesota, United States, 55430
United States, North Carolina
Cary, North Carolina, United States, 27511
Greenville, North Carolina, United States, 27834
New Bern, North Carolina, United States, 28562
Raleigh, North Carolina, United States, 27610
United States, South Carolina
Aiken, South Carolina, United States, 29801
United States, Texas
San Antonio, Texas, United States, 78215
San Antonio, Texas, United States, 78228
United States, Virginia
Norfolk, Virginia, United States, 23507 收起 <<
United States, Maine
... 展开 >>
Maine Medical Center
Portland, Maine, United States, 04102
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232 收起 <<
United States, Arizona
... 展开 >>
University of Arizona
Tucson, Arizona, United States, 85724
United States, California
University of California- Irvine
Irvine, California, United States, 92697
University of California, San Diego
La Jolla, California, United States, 92037
University of California, Los Angeles
Los Angeles, California, United States, 90095
United States, Florida
Wien Center, Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
United States, Kentucky
University of Kentucky
Lexington, Kentucky, United States, 40536
United States, New Jersey
University of Medicine and Dentistry of New Jersey
Piscataway, New Jersey, United States, 08855
United States, New York
Neurological Care of CNY
Syracuse, New York, United States, 13210
United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44120
United States, Oregon
Oregon Health Sciences University
Portland, Oregon, United States, 97239
United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, South Carolina
Medical University of South Carolina
North Charleston, South Carolina, United States, 29406
United States, Washington
University of Washington
Seattle, Washington, United States, 98108 收起 <<
Cognitive Disorders
... 展开 >> HIV Infections 收起 <<
Phase 2
Completed
-
United States, Maryland
... 展开 >>
Johns Hopkins Hosp
Baltimore, Maryland, United States, 212876965
United States, New York
Columbia Univ
New York, New York, United States, 10032
Univ of Rochester Med Ctr
Rochester, New York, United States, 14642 收起 <<
Israel
... 展开 >> Wolfson Medical Center, Diabetes Unit
Holon, Israel, 58100
Haddassah Medical Center Ein Kerem, Diabetes Unit
Jerusalem, Israel, 91120
Russian Federation
Chair of Nervous Diseases of IM Sechenov Moscow Medical Academy at City Clinical Hospital
Moscow, Russian Federation, 119048
Chair of Endocrinology and Diabetology of Russian Medical Academy of Postgraduate Education at Central Clinical Hospital of Ministry of Communication RF
Moscow, Russian Federation, 125315
Federal Centre of Medical Social Expertise and Rehabilitation of Invalids, Centre Diabetic Food
Moscow, Russian Federation, 127486 收起 <<
United States, Oregon
... 展开 >>
VA Medical Center, Portland
Portland, Oregon, United States, 97201
Oregon Health & Science University
Portland, Oregon, United States, 97239 收起 <<
Acquired Immunodeficiency Synd... 展开 >>rome
HIV Infections 收起 <<
Phase 2
Completed
-
United States, California
... 展开 >>
Quest Clinical Research
San Francisco, California, United States, 94115
Eye Clinic, Santa Clara Valley Medical Center
San Jose, California, United States, 95128 收起 <<
Neurotoxicity
... 展开 >> Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific 收起 <<
Phase 3
Completed
-
United States, Arkansas
... 展开 >>
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, United States, 72913
United States, Indiana
Horizon Oncology Center
Lafayette, Indiana, United States, 47905
United States, Kansas
CCOP - Wichita
Wichita, Kansas, United States, 67214-3882
United States, Louisiana
Cabrini Center for Cancer Care at Christus St. Frances Cabrini Hospital
Alexandria, Louisiana, United States, 71301
United States, Michigan
CCOP - Kalamazoo
Kalamazoo, Michigan, United States, 49007-3731
United States, Minnesota
CCOP - Metro-Minnesota
St. Louis Park, Minnesota, United States, 55416
United States, Missouri
Cancer Research for the Ozarks
Springfield, Missouri, United States, 65804
United States, Oregon
CCOP - Columbia River Oncology Program
Portland, Oregon, United States, 97225
United States, Pennsylvania
CCOP - Main Line Health
Wynnewood, Pennsylvania, United States, 19096
United States, South Carolina
CCOP - Greenville
Greenville, South Carolina, United States, 29615
United States, Texas
University of Texas M.D. Anderson CCOP Research Base
Houston, Texas, United States, 77030-4009
CCOP - Scott and White Hospital
Temple, Texas, United States, 76508
United States, Wisconsin
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, United States, 54449 收起 <<
United States, Oregon
... 展开 >>
Oregon Health & Science University
Portland, Oregon, United States, 97239
Portland VA Medical Center
Portland, Oregon, United States, 97239 收起 <<
Korea, Republic of
... 展开 >>
Asan Medical Center
Recruiting
Seoul, Korea, Republic of, 138-736
Contact: Tae Yong Kim, MD, PhD 82-2-3010-3249 tykim@amc.seoul.kr
Principal Investigator: Won Bae Kim, MD, PhD 收起 <<
Iran, Islamic Republic of
... 展开 >>
Shiraz University of Medical Sciences, Department of Nutrition
Recruiting
Shiraz, Fars, Iran, Islamic Republic of, 7157617516
Contact: Najmeh Hejazi, PhD n20hejazi@yahoo.com
Principal Investigator: Najmeh Hejazi, PhD 收起 <<
Acute Kidney Injury
... 展开 >> The Changes of Plasma Creatinine
The Changes of Plasma Free Radicals
The Changes of Endothelium-dependent Arterial Dilation 收起 <<
Suspended(Low number of patien... 展开 >>ts enrolled) 收起 <<
January 2017
United States, Michigan
... 展开 >>
Ferris State University
Big Rapids, Michigan, United States, 49307
Retina Specialists of Michigan
Grand Rapids, Michigan, United States, 49525 收起 <<
United States, Oregon
... 展开 >>
Oregon Health & Science University
Recruiting
Portland, Oregon, United States, 97239
Principal Investigator: Vijayshree Yadav, MBBS, MCR 收起 <<
United Kingdom
... 展开 >> Diabetes Department, St John's Hospital
Recruiting
Livingston, Scotland, United Kingdom, EH54 6PP
Principal Investigator: James D Walker, MD 收起 <<
United States, Iowa
... 展开 >>
University of Iowa Hospitals and Clinics, Department of Ophthalmology & Visual Sciences
Iowa City, Iowa, United States, 52242
United States, New Jersey
NJ Retina
Teaneck, New Jersey, United States, 07666
United States, Oregon
Oregon Regina. LLP
Eugene, Oregon, United States, 97401
Retina Northwest, P.C.
Portland, Oregon, United States, 97210
United States, Pennsylvania
Scheie Eye Institute of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 收起 <<
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Not yet recruiting
Birmingham, Alabama, United States, 35294
Contact: Kerry Howard 205-934-1885 kdhoward@uabmc.edu
Contact: John Rinker II, MD jrinker@uabmc.edu
United States, District of Columbia
Washington DC VA Medical Center, Washington, DC
Not yet recruiting
Washington, District of Columbia, United States, 20422
Contact: Heidi Maloni, PhD 202-745-8000 ext 57873 Heidi.Maloni@va.gov
Contact: Mitchell T Wallin, MD 2027458146 mitchell.wallin@va.gov
United States, Oregon
VA Portland Health Care System, Portland, OR
Recruiting
Portland, Oregon, United States, 97239
Contact: Carin Waslo 503-418-2141 waslo@ohsu.edu
Contact: Cassidy A Taylor (503) 220-8262 Cassidy.Taylor@va.gov
Principal Investigator: Rebecca I. Spain, MD MSPH
United States, Utah
University of Utah
Recruiting
Salt Lake City, Utah, United States, 84148
Contact: LaWanda Esquibel 801-587-3864 Lawanda.Esquibel@hsc.utah.edu
Contact: Mateo Paz Soldan, MD miguel.pazsoldan@va.gov
VA Salt Lake City Health Care System, Salt Lake City, UT
Recruiting
Salt Lake City, Utah, United States, 84148
Contact: Connie Kawai 323-442-5814 constance.kawai@med.usc.edu
Contact: Lawanda Esquibel 8015873864 lawanda.esquibel@hsc.utah.edu
United States, Vermont
University of Vermont
Recruiting
Burlington, Vermont, United States, 05401
Contact: Roman Pettigrew 802-847-6039 Roman.Pettigrew@uvmhealth.org
Contact: Andrew Solomon, MD 8028474589 Andrew.Solomon@uvmhealth.org
United States, Washington
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Not yet recruiting
Seattle, Washington, United States, 98108
Contact: Alicia Sloan, MSW 800-329-8387 ext 63593 alicia.sloan@va.gov
Contact: Jodie Haselkorn, MD Jodie.Haselkorn@va.gov
Swedish Medical Center
Recruiting
Seattle, Washington, United States, 98122
Contact: Laura Johnson 206-320-7115 laura.johnson3@swedish.org
Contact: Pavle Repovic, MD 2063202200 Pavle.Repovic@swedish.org
Canada, Ontario
Ottawa Hospital Research Institute
Not yet recruiting
Ottawa, Ontario, Canada, K1Y 4E9
Contact: Carol Freedman 613-737-8104 ext 2 cfreedman@toh.ca
Contact: Mark Freedman, MD mfreedman@toh.ca 收起 <<
United States, Oregon
... 展开 >>
Oregon Health & Science University
Recruiting
Portland, Oregon, United States, 97239
Contact: Cassidy Taylor taylocas@ohsu.edu
Principal Investigator: Michelle Cameron 收起 <<
Korea, Republic of
... 展开 >>
The Catholic University of Korea
Seoul, Korea, Republic of, 137-701
Eulji General Hospital
Seoul, Korea, Republic of
Sejong General Hospital
Seoul, Korea, Republic of 收起 <<
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