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货号 产品名 纯度
A232139 现货 Volasertib/伏拉塞替

Volasertib(BI 6727)是一种口服活性、高效和ATP竞争性的Polo样激酶1(PLK1)抑制剂,IC50为0.87 nM。它抑制PLK2PLK3IC50值分别为5 nM和56 nM,诱导有丝分裂停滞和凋亡。Volasertib是一种二氢蝶啶酮衍生物,在多种癌症模型中表现出显著的抗肿瘤活性。

98%
A203461 现货 BI 2536

BI 2536是一种PLK1和BRD4的双重抑制剂,对它们的IC50分别为0.83 nM和25 nM。BI-2536还抑制IFNB基因转录。

99%+
A1474056 现货 ON1231320

98%
A136004 现货 HMN-214

HMN-214 is a potent PLK1 inhibitor an average IC50 of 0.12 μM, and a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.

99%+
A600407 现货 Poloxin

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.

99%+
A528615 现货 Ro3280

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

99%
A1362661 现货 (1E)-CFI-400437 2HCl

CFI-400437 is a selective ATP-competitive PLK4 inhibitor with IC50 value of 1.55nM.

98%+
A690685 现货 MLN0905

MLN0905 is a small-molecule and potent inhibitor of PLK1 with IC50 of 2 nM.

99%+
A965277 现货 TC-S 7005

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

98%
A139789 现货 Rigosertib/瑞格色替

Rigosertib is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM and shows 30-fold greater selectivity against PLK2 and no activity to PLK3.

98%+
A464869 现货 C6 Ceramide

97%
A639858 现货 LFM-A13

LFM-A13 is specific inhibitor of bruton’s tyrosine kinase (BTK) with IC50 of 17.2 µM and 2.5 µM for recombinant BTK.

98%+
A541635 现货 Centrinone

Centrinone is a selective and reversible inhibitor of polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole/centrosome assembly.

98%
A247643 现货 3MB-PP1

95%
A335666 现货 CFI-400945

CFI400945 is a potent and selective,orally bioavailable PLK4 inhibitor with an IC50 value of 2.8 ±1.4 nM have potential antineoplastic activity.

98%
A266562 现货 (E/Z)-Rigosertib sodium

Rigosertib Sodium (Random Configuration) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.

99%+
A527359 现货 SBE13 HCl/SBE 13盐酸盐

SBE13 HCl is a potent and selective PLK1 inhibitor with IC50 of 0.2 nM while 875 nM and 66 μM for PLK3 and PLK2. SBE 13 could also induce cell cycle arrest, reduce cell proliferation with EC50 of 5-60 µM, and induce apoptosis in a broad range of human cancer cell lines.

98%
A443707 现货 Onvansertib

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC50=2 nM) with potential antineoplastic activity and no inhibition on PLK2 and PLK3.

99%+
A313486 现货 GSK461364

GSK461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM.

99%+
A621588 现货 TAK-960

TAK-960 is an investigational, orally bioavailable, potent, and selective PLK1 inhibitor (IC50=1.5 nM) that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1).

99%+
产品名 PLK1 PLK2 PLK3 PLK4 其他靶点 纯度
HMN-214 99%+
SBE13 HCl ++++

PLK1, IC50: 200 pM

98%
Onvansertib +++

PLK1, IC50: 2 nM

99%+
Volasertib ++++

PLK1, IC50: 0.87 nM

98%
GSK461364 +++

PLK1, Ki: 2.2 nM

99%+
MLN0905 +++

PLK1, IC50: 2 nM

99%+
Ro3280 ++

PLK1, IC50: 3 nM

99%
(E/Z)-Rigosertib sodium +

PLK1, IC50: 9 nM

+

PLK2, IC50: 260 nM

Bcr-Abl 99%+
BI 2536 ++++

PLK1, IC50: 0.83 nM

++

PLK2, IC50: 3.5 nM

+

PLK3, IC50: 9.0 nM

99%+
CFI-400945 ++

PLK4, IC50: 2.8 nM

Tie-2 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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