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/ Oxysophocarpine/氧卡地平

Oxysophocarpine/氧卡地平 {[allProObj[0].p_purity_real_show]}

货号：A633566 同义名： 氧化槐果碱 / Sophocarpine N-oxide; OSC

Oxysophocarpine 是一种自 Styphnolobium japonicum 根部分离纯化的天然产物，可降低血清转氨酶水平、改善脂质代谢、减少炎症细胞因子 TNF-α、TGF-β1 和 IL-6 的合成，并激活保护性脂肪细胞因子 adiponectin，常被用于研究结肠炎及非酒精性脂肪性肝病（NASH）。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Oxysophocarpine/氧卡地平 化学结构 CAS号：26904-64-3
Oxysophocarpine/氧卡地平 化学结构
CAS号：26904-64-3
Oxysophocarpine/氧卡地平 3D分子结构
CAS号：26904-64-3
Oxysophocarpine/氧卡地平 化学结构 CAS号：26904-64-3
Oxysophocarpine/氧卡地平 3D分子结构 CAS号：26904-64-3
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Oxysophocarpine/氧卡地平 纯度/质量文件 产品仅供科研

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Oxysophocarpine/氧卡地平 生物活性

描述 Oxysophocarpine, a natural product isolated and purified from the root of Styphnolobium japonicum (L.) Schott., can decrease the level of serum transaminase, improve lipid metabolism, reduce synthesis of inflammatory cytokines TNF-α, TGF-β1 and IL-6, activate protective adipocytokine adiponectin, and may be a drug for colonic inflammation and NASH.

Oxysophocarpine/氧卡地平 细胞实验

Cell Line
Concentration Treated Time Description References
HT-22 cells 1.25, 2.5, 5, 10 µM 12 hours To evaluate the effect of Oxysophocarpine on HT-22 cell viability. Results showed that 20 µM Oxysophocarpine produced cytotoxicity to HT-22 cells, reducing cell viability to 74.02% ± 3.17%. However, 1.25, 2.5, 5, and 10 µM Oxysophocarpine did not significantly affect HT-22 cell viability. Curr Issues Mol Biol. 2024 Nov 16;46(11):13035-13049
Neonatal rat primary-cultured hippocampal neurons 0.8, 2, or 5 µM 24 hours To evaluate the protective effect of oxysophocarpine on oxygen-glucose deprivation/reperfusion (OGD/R)-induced injury in hippocampal neurons. Results showed that oxysophocarpine significantly increased cell viability and reduced lactate dehydrogenase (LDH) release, indicating its protective effect against neuronal damage. Cell Mol Neurobiol. 2018 Mar;38(2):529-540
HFF 0.16 mg/mL 48 hours To evaluate the effect of oxysophocarpine on fibroblast apoptosis. Results showed that CKI-OmtOspc and CKI-MacOmtOspc significantly induced apoptosis in HFF cells. Sci Rep. 2019 Oct 2;9(1):14200
HEK-293 0.29 mg/mL 48 hours To evaluate the effect of oxysophocarpine on kidney cell apoptosis. Results showed that CKI-OmtOspc and CKI-MacOmtOspc significantly induced apoptosis in HEK-293 cells. Sci Rep. 2019 Oct 2;9(1):14200
MDA-MB-231 0.82 mg/mL 48 hours To evaluate the effect of oxysophocarpine on breast cancer cell viability and apoptosis. Results showed that the removal of oxymatrine and oxysophocarpine combination (CKI-OmtOspc) significantly decreased cell viability and increased apoptosis. Sci Rep. 2019 Oct 2;9(1):14200
LX-2 cells 0.5, 1, 1.5 mg/mL 6, 12, 24 hours To evaluate the effect of oxysophocarpine on TGF-β1-induced trans-differentiation of LX-2 cells. Results showed that oxysophocarpine significantly inhibited the expression of TGF-β1, COL1A, Fibronectin, and TIMP1 in TGF-β1-treated LX-2 cells. Clin Transl Med. 2021 Jul;11(7):e410.

Oxysophocarpine/氧卡地平 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Adult male ICR mice Pilocarpine-induced epilepsy model Intraperitoneal injection 20, 40, and 80 mg/kg Single administration, continuously observed for 90 minutes To evaluate the anticonvulsant and neuroprotective effects of Oxysophocarpine on pilocarpine-induced epilepsy. Results showed that OSC (40, 80 mg/kg) significantly delayed the onset of the first convulsion and status epilepticus (SE), reduced the incidence of SE and mortality. EEG analysis revealed that OSC reduced epileptiform discharges. Nissl and FJB staining showed that OSC attenuated neuronal cell loss and degeneration in the hippocampus. Additionally, OSC attenuated changes in MDA levels and enhanced glutathione peroxidase and catalase activity in the hippocampus. Western blot analysis indicated that OSC significantly decreased Bax and Caspase-3 expressions while increasing Bcl-2 expression. Cell Mol Neurobiol. 2017 Mar;37(2):339-349

Oxysophocarpine/氧卡地平 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02239237 - Completed - China, Hebei ... 展开 >> HanDan Central Hospital HanDan, Hebei, China, 056001 Handan First Hospital Handan, Hebei, China, 056002 Bai Qiu'en International Peace Hospital Shijiazhuang, Hebei, China, 050082 China, Henan Henan University Huaihe Hospital Kaifeng, Henan, China, 475001 The First Affiliated Hospital of Henan University of Science & Technology Luoyang, Henan, China, 471000 Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang, Henan, China, 471009 Xinxiang Central Hospital Xinxiang, Henan, China, 453000 The First Affiliated Hospital of Xinxiang Medical University Xinxiang, Henan, China, 453199 Xinyang Central Hospital Xinyang, Henan, China, 464000 People's Hospital of Zhengzhou Zhengzhou, Henan, China, 450003 Henan Cancer Hospital Zhengzhou, Henan, China, 450008 The First Hospital of Henan College of Traditional Chinese Medicine Zhengzhou, Henan, China, 451199 China, Shandong Shandong Provincial Western Hospital Jinan, Shandong, China, 250022 Qingdao Center Hospital Qingdao, Shandong, China, 266031 Tai'an Central Hospital Tai'an, Shandong, China, 271000 The 88th Hospital of People's Liberation Army Tai'an, Shandong, China, 271002 People's Hospital of Xintai City Tai'an, Shandong, China, 271200 Weifang No.2 People's Hospital Weifang, Shandong, China, 261041 Weihai Municipal Hospital Weihai, Shandong, China, 264299 Central Hospital of Zibo Zibo, Shandong, China, 255020 China, Shanxi Jincheng General Hospital Jincheng, Shanxi, China, 048006 The Fourth People's Hospital of Linfen Linfen, Shanxi, China, 041099 Traditional Chinese Hospital of Shanxi Taiyuan, Shanxi, China, 030012 Yuncheng Central Hospital Yuncheng, Shanxi, China, 044099 China, Sichuan Chengdu Second People's Hospital Chengdu, Sichuan, China, 610017 AVIC 363 Hospital Chengdu, Sichuan, China, 610041 Teaching Hospital of Chengdu University of T.C.M. Chengdu, Sichuan, China, 610072 The Second People's Hospital of Yibin Yibin, Sichuan, China, 644000 China, Tianjin Tianjin medical university cancer institute & hosptial Tianjin, Tianjin, China, 300060 收起 <<

Oxysophocarpine/氧卡地平 参考文献

[1]Wu L, Zhong W, et al. Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat. Fitoterapia. 2015 Sep;105:26-36.

[2]Yang Y, Li YX, et al. Oxysophocarpine Ameliorates Carrageenan-induced Inflammatory Pain via Inhibiting Expressions of Prostaglandin E2 and Cytokines in Mice. Planta Med. 2015 Jul;81(10):791-7.

Oxysophocarpine/氧卡地平 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.81mL

0.76mL

0.38mL

19.06mL

3.81mL

1.91mL

38.12mL

7.62mL

3.81mL

Oxysophocarpine/氧卡地平 技术信息

CAS号26904-64-3
分子式C15H22N2O2
分子量 262.35
SMILES Code O=N12[C@@]3([C@@]([H])([C@@]4(N(C[C@@]3(CCC2)[H])C(C=CC4)=O)[H])CCC1)[H]
MDL No. MFCD08689951
别名 氧化槐果碱 ;Sophocarpine N-oxide; OSC; Oxysophocarpine, Sophocarpine N-oxide; (+)-Oxysophocarpine
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C
溶解方案

DMSO: 35 mg/mL(133.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(190.59 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Oxysophocarpine | 26904-64-3 | neuroprotective | anti-nociceptive | Natural Products | Disease Research Fields | Plants | Alkaloids | Leguminosae | Cancer | Piperidine Alkaloids | Sophora alopecuroides L | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Oxysophocarpine/氧卡地平 纯度/质量文件 | Oxysophocarpine/氧卡地平 生物活性 | Oxysophocarpine/氧卡地平 临床数据 | Oxysophocarpine/氧卡地平 参考文献 | Oxysophocarpine/氧卡地平 实验方案 | Oxysophocarpine/氧卡地平 技术信息

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