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货号 产品名 纯度
A169993 现货 MIK665

MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.

99%+
A204180 现货 Navitoclax

Navitoclax (ABT-263) 是一种口服有效的 Bcl-2 抑制剂,可与多种 Bcl-2 家族蛋白结合,Ki 值小于 1 nM。

99%+
A211104 现货 Sabutoclax

Sabutoclax is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

98%
A985501 现货 BI-3812

BI-3812 is a BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM.

98%
A240729 现货 CID5721353

CID5721353 is a B-Cell Lymphoma 6 inhibitor (BCL6 inhibitor).

99%+
A169042 现货 Azoramide/N-(2-(2-(4-氯苯基)噻唑-4-基)乙基)丁酰胺

Azoramide is a modulator of the unfolded protein response (UPR) with antidiabetic activity.

99%+
A116740 现货 A-1210477

A-1210477是一种高效且选择性的 MCL-1 抑制剂,Ki 为 0.45 nM。它特异性结合 MCL-1 并促进依赖 MCL-1 的癌细胞凋亡

99%+
A189286 现货 BH3I-1

BH3I-1 is an inhibitor of Bcl-xL with IC50 of 293.95 μM.

98%
A571691 现货 (R)-(-)-Gossypol acetic acid/(R)-(-)-醋酸棉酚

AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.

98%
A942774 现货 BTSA1

BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity, induces conformational changes to BAX leading to BAX-mediated apoptosis.

99%+
A272644 现货 Obatoclax/奥巴克拉 (GX15-070)

Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 μMol/L), including Mcl-1 (IC50, 2.9 μMol/L) and Bfl-1 (IC50, 5 μMol/L).

99%+
A821402 现货 ABT-737

ABT-737 是一种选择性的 Bcl-2 家族蛋白抑制剂,能够有效抑制 Bcl-2Bcl-xLBcl-w 的活性,IC50 值分别为 30.3 nM、78.7 nM 和 197.8 nM。ABT-737 主要用于研究细胞凋亡、抗癌治疗和增强肿瘤对化疗药物的敏感性。

99%+
A887253 现货 S55746

S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities.

99%
A241007 现货 Alisol B/泽泻醇B

Alisol B is a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn. for bone disorders by targeting the differentiation of osteoclasts as well as their functions.

98%
A1216719 现货 MCL-1/BCL-2-IN-2

MCL-1/BCL-2-IN-2是一种有效的选择性 Mcl-1Bcl-2 抑制剂。

98%+
A206174 现货 A-1331852

A1331852 is a potent and selective BCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.

99%+
A1142868 现货 ML311

ML311, also known as EU-5346, is a selective inhibitor of the interaction of Mcl-1 and Bim.

98%+
A1217964 现货 Gossypol (acetic acid)/醋酸棉酚

Gossypol acetic, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

98% (mix)
A1234862 现货 Bcl-B inhibitor 1

Bcl-B inhibitor 1是一种选择性的 Bcl-B 蛋白抑制剂,在调节凋亡途径和抗癌药物开发中有重要应用价值。

99%+
A1145366 现货 Phytohemagglutinin/植物血凝素

Phytohemagglutinin (PHA-M), a lectin extract from the red kidney bean and a standard T cell mitogen, as an inhibitor of both T- and B-cell tumors. Phytohemagglutinin can inhibit incorporation of 3H-thymidine and mediate apoptosis of B- and T-cell tumor lines. Anti-tumor activity .

lyophilized
产品名 Bax Bcl-2 Bcl-B Bcl-w Bcl-xL Bfl-1 Mcl-1 其他靶点 纯度
BTSA1 99%+
HA14-1 +

Bcl-2, IC50: 9 μM

98%
Venetoclax ++++

Bcl-2, Ki: <0.01 nM

99%
Navitoclax 99%+
Obatoclax Mesylate +++

Bcl-2, Ki: 0.22 μM

98%
ABT-737 +++

Bcl-2, EC50: 30.3 nM

+

Bcl-B, EC50: 1.82 μM

+++

Bcl-w, EC50: 197.8 nM

+++

Bcl-xL, EC50: 78.7 nM

99%+
Gambogic Acid +

Bfl-1, IC50: 1.06 μM

Bcl-2, IC50: 1.21 μM

++

Bcl-B, IC50: 0.66 μM

++++

Bcl-w, IC50: 0.02 μM

+

Bcl-xL, IC50: 1.47 μM

+

Bfl-1, IC50: 1.06 μM

++

Mcl-1, IC50: 0.79 μM

Caspase 99% HPLC
BH3I-1 +

BH3-Bcl-xL interaction, Ki: 2.4 μM

98%
A-1331852 ++++

Bcl-xL, Ki: <0.01 nM

99%+
A-1210477 ++++

MCL-1, IC50: 26.2 nM

99%+
Maritoclax 97%
TW-37 +++

Bcl-2, Ki: 0.29 μM

+

Bcl-xL, Ki: 1.11 μM

+++

Mcl-1, Ki: 0.26 μM

98%
UMI-77 ++

Mcl-1, Ki: 490 nM

97%
(R)-(-)-Gossypol acetic acid ++

Bcl-2, Ki: 0.32 μM

++

Bcl-xL, Ki: 0.48 μM

+++

Mcl-1, Ki: 0.18 μM

98%
Sabutoclax ++

Bfl-1, IC50: 0.62 μM

Bcl-2, IC50: 0.32 μM

++

Bcl-xL, IC50: 0.31 μM

++

Bfl-1, IC50: 0.62 μM

+++

Mcl-1, IC50: 0.20 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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