beta-Mangostin, a natural product isolated and purified from the fruits of Garcinia mangostana, can decrease the total leukocyte migration and reduce the levels of TNF-α and IL-1β in peritoneal fluid, as well as exhibits strong antibacterial activity against B.cereus.
beta-Mangostin/Β-倒捻子素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HaCaT cells
10 μM
No reduction in melanin content observed
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2318039121
B16BL6 cells
10 μM
Reduced melanin content, effect inhibited by 3-MA
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2318039121
T89G cells
10.320 μM
To evaluate the effect of β-Mangostin on T89G cell viability, results showed it could inhibit cell growth
Drug Des Devel Ther. 2020 Dec 1;14:5315-5324
U251 cells
5.831 μM
To evaluate the effect of β-Mangostin on U251 cell viability, results showed it could inhibit cell growth
Drug Des Devel Ther. 2020 Dec 1;14:5315-5324
Rat C6 glioma cells
0-25 μM
24 h
To evaluate the effect of β-Mangostin on C6 cell viability, results showed it could inhibit glioma cell growth and induce oxidative damage
Drug Des Devel Ther. 2020 Dec 1;14:5315-5324
B16F10 cells
10 μM
48 h
Induced melanosome degradation, reduced TRP-1 puncta and melanin content
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2318039121
beta-Mangostin/Β-倒捻子素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague Dawley rats
Ethanol-induced gastric ulcer model
Oral
5, 10, 20 mg/kg
Single dose, ulcer induced after 1 hour
To evaluate the gastroprotective effects and mechanisms of beta-Mangostin against ethanol-induced gastric ulcer. Results showed protection via antisecretory, mucus enhancement, antioxidant, HSP70 upregulation, antiapoptotic, and anti-H. pylori activities.
Drug Des Devel Ther. 2016 Jan 13;10:297-313
Mice
Unilateral ureteral obstruction (UUO) model
Oral
10 or 20 mg/kg
Once daily for 7 days
Β-Mag alleviated UUO-induced renal tubulointerstitial damage in a dose-dependent manner, reducing collagen I fiber deposition and suppressing fibrotic (collagen I, α-SMA) and EMT (N-cadherin, Vimentin, Snail, Slug) marker expression.
Cells. 2024 Oct 14;13(20):1701
BALB/c nude mice
Subcutaneous xenograft model
Tail vein injection
5 mg/kg
To evaluate the inhibitory effect of β-Mangostin on tumor growth, results showed it could significantly inhibit the growth of C6 tumor xenografts
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