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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / 前列腺素受体 / Dinoprost tromethamine salt/地诺前列素氨丁三醇

Dinoprost tromethamine salt/地诺前列素氨丁三醇 {[allProObj[0].p_purity_real_show]}

货号：A385706 同义名： 地诺前列素 / Prostaglandin F2α THAM; Prostaglandin F2α tromethamine salt

Dinoprost tromethamine salt是一种天然前列腺素，用作堕胎药。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Dinoprost tromethamine salt/地诺前列素氨丁三醇 化学结构 CAS号：38562-01-5
Dinoprost tromethamine salt/地诺前列素氨丁三醇 化学结构
CAS号：38562-01-5
Dinoprost tromethamine salt/地诺前列素氨丁三醇 3D分子结构
CAS号：38562-01-5
Dinoprost tromethamine salt/地诺前列素氨丁三醇 化学结构 CAS号：38562-01-5
Dinoprost tromethamine salt/地诺前列素氨丁三醇 3D分子结构 CAS号：38562-01-5
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Dinoprost tromethamine salt/地诺前列素氨丁三醇 纯度/质量文件 产品仅供科研

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Dinoprost tromethamine salt/地诺前列素氨丁三醇 生物活性

描述 Dinoprost tromethamine salt, also known as Prostaglandin F2α tromethamine salt, is a potent agonist of the prostaglandin F (PGF) receptor (FP receptor) that can be administered orally. It acts as a luteolytic hormone primarily synthesized in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a pivotal role in initiating and advancing labor [1][2].
体外研究

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours), triggers endoplasmic reticulum (ER) stress, autophagy, and apoptosis in goat luteal cells [1].

Dinoprost tromethamine salt (1 μM; for 24 hours) markedly upregulates the expression of GRP78 and UPR sensors [1].

Dinoprost tromethamine salt/地诺前列素氨丁三醇 细胞实验

Cell Line
Concentration Treated Time Description References
Mouse primary granulosa lutein cells 1.5 μM 36 hours Induced RIPK3 expression and led to apoptosis Elife. 2021 May 24;10:e67409
Human granulosa lutein cells (KGN) 1.5 μM 36 hours Induced RIPK3 expression and led to apoptosis Elife. 2021 May 24;10:e67409

Dinoprost tromethamine salt/地诺前列素氨丁三醇 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Hyper-ovulation model Intraperitoneal injection 10 μg Single injection, ovaries collected 24 hours later Induced luteal regression in ovaries through RIPK3-mediated apoptosis pathway Elife. 2021 May 24;10:e67409
Dairy cows Cows after natural ovulation Intramuscular injection 25 mg Single dose, monitored until Day 18 To investigate the factors affecting the interval to ovulation, the type of ovulated follicle, and the cause of anovulation after PG treatment. Results showed that the interval to ovulation, the type of ovulated follicle, and anovulation were related to the ability of the follicle to secrete E2. J Vet Med Sci. 2020 May 15;82(5):590-597
Lactating Holstein cows Lactating Holstein cows Subcutaneous (neck) or intramuscular (semitendinosus muscle) 25 mg Single administration, monitored for 72 hours To compare the effects of different administration routes on PGFM and progesterone concentrations. SC cows had greater circulating PGFM concentrations from 15 to 90 minutes post-treatment than IM cows, but the decrease in circulating P4 concentrations during induced luteolysis did not differ between treatments. J Anim Sci. 2020 Nov 30;98(Suppl 4):377
Dairy cows Cows with natural and induced estrus Intramuscular injection 25 mg Single dose To investigate the relationship between endometrial thickness and progesterone and estradiol concentrations during natural and induced estrus. Results showed that endometrial thickness in the induced estrus group was significantly greater than that in the natural estrus group between 60 and 12 h before ovulation. J Reprod Dev. 2018 Apr 13;64(2):135-143
Dairy cows Intramuscular injection 25 mg Single administration Evaluate the effects on estrus cycle and fertility in dairy cows PLoS One. 2021 Aug 9;16(8):e0248453

Dinoprost tromethamine salt/地诺前列素氨丁三醇 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02052908 Lynch Syndrome Phase 1 Active, not recruiting - United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Utah Huntsman Cancer Institute/University of Utah Salt Lake City, Utah, United States, 84112 收起 <<
NCT01974674 Patients With Type 1 Diabetes Phase 2 Recruiting January 2022 France ... 展开 >> Saint Louis hospital Recruiting Paris, Ile de France, France, 75010 Contact: Pierre CATTAN, MD PhD    33 1 42494786    pierre.cattan@sls.aphp.fr 收起 <<
NCT01688154 Triglyceride Metabolism ... 展开 >> Cardiovascular Function 收起 << Not Applicable Completed - Spain ... 展开 >> CTNS Reus, Tarragona, Spain, 43204 Technological Center of Nutrition and Health (CTNS) Reus, Tarragona, Spain, 43204 收起 <<

Dinoprost tromethamine salt/地诺前列素氨丁三醇 参考文献

[1]Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):938-45.

[2]Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868.

Dinoprost tromethamine salt/地诺前列素氨丁三醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.51mL

2.10mL

1.05mL

21.03mL

4.21mL

2.10mL

Dinoprost tromethamine salt/地诺前列素氨丁三醇 技术信息

CAS号38562-01-5
分子式C24H45NO8
分子量 475.62
SMILES Code CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O.OCC(CO)(N)CO
MDL No. MFCD00077863
别名 地诺前列素 ;Prostaglandin F2α THAM; Prostaglandin F2α tromethamine salt; Prostamate; U 14585; PGF2α; Dinoprost; Prostaglandin F2α (tromethamine salt); Dinoprost Trometamol; Prostin F2 alpha; Zinoprost; PGF2-alpha tham; Dinolytic; Dinoprost tromethamine; PGF2α THAM
运输蓝冰
InChI Key IYGXEHDCSOYNKY-RZHHZEQLSA-N
Pubchem ID 5282415
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(220.77 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(210.25 mM)

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Dinoprost | 38562-01-5 | Prostaglandin F2α | PGF2α THAM | Prostaglandin F2α THAM | FP Receptor Agonist | GPCR/G Protein | Metabolic Enzyme/Protease | Autophagy | Apoptosis | Prostaglandin Receptor | Endogenous Metabolite | Autophagy | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 纯度/质量文件 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 生物活性 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 临床数据 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 参考文献 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 实验方案 | Dinoprost tromethamine salt/地诺前列素氨丁三醇 技术信息

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