There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
p-Tolylmaleimide, a derivative of naphthalimide, exhibits cytotoxicity against cancer cells. It arrests the cell cycle of K562 human acute myeloid leukemia cells in the sub-G0/G1 phase and induces apoptosis [1].
*该产品中的马来酰亚胺基团在碱性水溶液中会发生水解形成开环的马来酸酰胺衍生物，会影响生物学活性，例如无法和巯基形成共价硫醚键，影响和生物大分子的连接，建议现配现用，避免在水溶液中长期保存，可在中性或弱酸性水溶液中低温保存，反应时控制弱酸环境[2][3]。
体外研究
p-Tolylmaleimide demonstrates inhibitory activity against human acute myeloid leukemia cells K562, with IC50 values of 24.99 μM (24 h), 6.61 μM (48 h), and 12.10 μM (72 h) respectively. Similarly, p-Tolylmaleimide inhibits human acute myeloid leukemia cells Jurkat, with IC50 values of 27.16 μM (24 h), 15.51 μM (48 h), and 3.94 μM (72 h) respectively [1].
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HazMat Fee +
