p-Tolylmaleimide

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Chemical Structure| 1631-28-3 同义名 : -
CAS号 : 1631-28-3
货号 : A575031
分子式 : C11H9NO2
纯度 : 95%
分子量 : 187.19
MDL号 : MFCD00022581
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 p-Tolylmaleimide, a derivative of naphthalimide, exhibits cytotoxicity against cancer cells. It arrests the cell cycle of K562 human acute myeloid leukemia cells in the sub-G0/G1 phase and induces apoptosis [1]. *该产品中的马来酰亚胺基团在碱性水溶液中会发生水解形成开环的马来酸酰胺衍生物，会影响生物学活性，例如无法和巯基形成共价硫醚键，影响和生物大分子的连接，建议现配现用，避免在水溶液中长期保存，可在中性或弱酸性水溶液中低温保存，反应时控制弱酸环境[2][3]。
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.34mL

1.07mL

0.53mL

26.71mL

5.34mL

2.67mL

53.42mL

10.68mL

5.34mL
参考文献

[1]Machado KE, et al. Apoptotic events induced by maleimides on human acute leukemia cell lines. Chem Res Toxicol. 2013 Dec 16;26(12):1904-16.

[2]Lyon RP, Setter JR, Bovee TD, Doronina SO, Hunter JH, Anderson ME, Balasubramanian CL, Duniho SM, Leiske CI, Li F, Senter PD. Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates. Nat Biotechnol. 2014 Oct;32(10):1059-62.

[3]Knight P. Hydrolysis of p-NN'-phenylenebismaleimide and its adducts with cysteine. Implications for cross-linking of proteins. Biochem J. 1979 Apr 1;179(1):191-7.