AER-271 is an aquaporin-4 inhibitor which can block the development of early cerebral edema, reduce early neurologic deficit, and blunt neuronal death and neuroinflammation post-cardiac arrest.

Steviol是甜菊苷的主要代谢产物，通过减少 AQP2 的表达并促进其降解来减缓肾囊肿的生长。