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ZZW-115 {[allProObj[0].p_purity_real_show]}

货号：A1365243

ZZW-115是一种高效的 NUPR1 抑制剂，Kd 值为 2.1 μM，可通过坏死和凋亡诱导肿瘤细胞死亡，具有抗癌活性。

ZZW-115 化学结构 CAS号：801991-87-7
ZZW-115 化学结构
CAS号：801991-87-7
ZZW-115 3D分子结构
CAS号：801991-87-7
ZZW-115 化学结构 CAS号：801991-87-7
ZZW-115 3D分子结构 CAS号：801991-87-7
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ZZW-115 纯度/质量文件 产品仅供科研

货号：A1365243 标准纯度： {[allProObj[0].p_purity_real_show]}
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ZZW-115 生物活性

描述 ZZW-115 is a potent NUPR1 inhibitor with a Kd value of 2.1 μM. ZZW-115 induces tumour cell death through necrosis and apoptosis[1][2].ZZW-115 was effective in killing cancer cells in the concentration range of 0.1-33 μM for 72 h. The IC50 of ZZW-115 ranged from 0.84 μM (ANOR) to 4.93 μM (HN14). ZZW-115 induced necrosis and apoptosis of pancreatic cells, and during its action, it caused a decrease in the production of ATP and induced the overproduction of ROS. LDH release from ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b and HN14 cells) was significantly higher than that from control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity was higher in ZZW-115-treated cells. These experiments suggest that ZZW-115 also has a pro-apoptotic effect[1].

ZZW-115 细胞实验

Cell Line
Concentration Treated Time Description References
MiaPaCa-2 cells 6 µM 6 hours Inhibition of NUPR1 activity impeded SGs formation EMBO Mol Med. 2024 Mar;16(3):475-505
MiaPaCa-2 cells 6 µM 6 hours Inhibition of NUPR1 activity impeded SGs formation J Clin Invest. 2019 Mar 28;129(6):2500-2513.
U87 and U251 glioblastoma cells 1.5 µM 12 hours To evaluate the enhancing effect of ZZW-115 on DNA damage induced by genotoxic agents (e.g., TMZ) in glioblastoma cells. JCI Insight. 2020 Sep 17;5(18):e138117
AOIPC primary PDAC cells 1.5 µM 12 hours To evaluate the enhancing effect of ZZW-115 on DNA damage induced by different genotoxic agents (5-FU, oxaliplatin, γ-radiation, and gemcitabine) in PDAC cells. JCI Insight. 2020 Sep 17;5(18):e138117
MiaPaCa-2 cells 3 or 5 µM 24 hours Demonstrated that our compound was able to induce cell death by apoptosis and necroptosis on a dose-dependent manner, by measuring caspase 3/7 activity or LDH release, respectively. Cells. 2019 Nov 17;8(11):1453
HCC cells (Huh7, PLC/PRF/5, Hep3B, LM3, MHCC-97H, MHCC-97L, SNU449, SNU387, HepG2) 5 µM 24 hours ZZW-115 inhibits NUPR1 activity, increases intracellular Fe2+ and lipid ROS levels, decreases GSH levels, induces ferroptosis, and thereby inhibits the proliferation and migration of HCC cells. Mol Cancer. 2024 May 28;23(1):113
Pancreatic cancer cells 1 µM 24 hours The cell death effect induced by ZZW-115 was systematically inhibited by olaparib, whereas PDD00017273 treatment enhanced the cell death effect. Commun Biol. 2022 Jul 22;5(1):732.
MiaPaCa-2 cells 1.5 µM 24 hours ZZW-115 treatment induced a strong increase in PARylation which is almost completely rescued by Ferrostatin-1, NAC, and Mitoquinone treatments. Commun Biol. 2022 Jul 22;5(1):732.
DLD1 cells 1 µM 24 hours ZZW-115 significantly increased the level of lipid peroxidation in RR cells and restored the sensitivity of RR cells to radiotherapy. J Cell Mol Med. 2025 Apr;29(7):e70519
RKO cells 1 µM 24 hours ZZW-115 significantly increased the level of lipid peroxidation in RR cells and restored the sensitivity of RR cells to radiotherapy. J Cell Mol Med. 2025 Apr;29(7):e70519
HepG2 cells 0.5-1.4 µM 24-72 hours To evaluate the effect of ZZW-115 on cell survival, results showed that Fer-1 (1 µM) increased cell viability and reduced intracellular ROS production. Cell Death Discov. 2021 Oct 1;7(1):269
MiaPaCa-2 cells 0.5-1.4 µM 24-72 hours To evaluate the effect of ZZW-115 on cell survival, results showed that Fer-1 (1 µM) increased cell viability and reduced intracellular ROS production. Cell Death Discov. 2021 Oct 1;7(1):269
9805 i-Kras cells 6 µM 6 hours Induced cell death in cells with activated KrasG12D, activated caspase 3 and released LDH J Clin Invest. 2019 Mar 28;129(6):2500-2513.
9805 i-Kras cells 6 µM 6 hours Induced cell death in cells with activated KrasG12D, activated caspase 3 and released LDH EMBO Mol Med. 2024 Mar;16(3):475-505
MiaPaCa-2 cells 5 µM 6 hours To study the effect of ZZW-115 on NUPR1 nuclear translocation, results showed that ZZW-115 almost completely inhibited the translocation of NUPR1 from the cytoplasm to the nucleus. JCI Insight. 2020 Sep 17;5(18):e138117

ZZW-115 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c nude mice HCC xenograft model Intraperitoneal injection 5 mg/kg Every five days for 25 days The combination of ZZW-115 and lenvatinib significantly inhibited the growth of HCC xenografts and enhanced the sensitivity of HCC cells to lenvatinib by inducing ferroptosis. Mol Cancer. 2024 May 28;23(1):113
Nude mice PANC1 or MIAPaCa2 xenograft models Intraperitoneal injection 5 mg/kg Once every other day for 2 weeks ZZW-115 increased the anticancer activity of IKE Nat Commun. 2021 Jan 28;12(1):647.

ZZW-115 动物研究

Animal study Immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells. ZZW-115 inhibited the growth of pancreatic xenograft tumours in mice at a dose of 0.5-5 mg/kg administered by daily injection for 30 days[1].

ZZW-115 参考文献

[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.

[2]Santofimia-Castaño P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8(11):1453. Published 2019 Nov 17.

ZZW-115 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.76mL

2.15mL

1.08mL

21.52mL

4.30mL

2.15mL

ZZW-115 技术信息

CAS号801991-87-7
分子式C24H31F3N4S
分子量 464.59
SMILES Code FC(F)(F)C1=CC=C(SC2=C3C=CC=C2)C(N3CCCN4CCN(CC4)CCN(C)C)=C1
MDL No. MFCD34469422
别名
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C

Tags: ZZW-115 | 801991-87-7 | ZZW115 | ZZW 115 | NUPR1 Inhibitor | Apoptosis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | ZZW-115 纯度/质量文件 | ZZW-115 生物活性 | ZZW-115 参考文献 | ZZW-115 实验方案 | ZZW-115 技术信息

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