There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Tubercidin, also known as 7-Deazaadenosine, is an antibiotic derived from Streptomyces tubercidicus. It demonstrates inhibitory action against Streptococcus faecalis, with an IC50 of 0.02 μM[1]. This compound acts by integrating into DNA or RNA, which results in the inhibition of DNA replication, as well as RNA and protein synthesis[2]. Tubercidin is also identified as a mild inhibitor of adenosine phosphorylase, affecting the phosphorylation processes of adenosine and AMP[1]. In a concentration range of 0-10 nM over 14 days, Tubercidin exerts a dose-dependent suppressive effect on both myeloid and erythroid progenitor cells in human bone marrow, with IC50 values of 3.4 nM for CFU-GM and 3.7 nM for BFU-E[3].
Tubercidin/杀结核菌素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Marc-145 cells
500 nM
24 hours
Evaluate the inhibitory effect of Tubercidin on PRRSV replication
Microbiol Spectr. 2024 Mar 5;12(3):e0347923
Marc-145 cells
150-500 nM
48 hours
Evaluate the cytotoxicity of Tubercidin on Marc-145 cells
Microbiol Spectr. 2024 Mar 5;12(3):e0347923
Leishmania major Friedlin (LmjF) parasites
0.9 and 1.8 µM
72 hours
To evaluate the antiparasitic activity of Tubercidin against LmjF parasites. Results showed that Tubercidin has significant antiparasitic activity against LmjF parasites.
PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004972
Tubercidin/杀结核菌素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
SCLC xenograft model
Subcutaneous injection
5 mg/kg
3 times per week for 3 weeks
To evaluate the anti-tumor effect of Tubercidin in the SCLC xenograft model. The results showed that Tubercidin treatment significantly inhibited the growth of DMS 114 tumors in nude mice, with the tumor volume and weight in the treatment group being significantly smaller than those in the control group.
J Cell Mol Med. 2022 May;26(9):2557-2565
Tubercidin/杀结核菌素 动物研究
Animal study
When administered via intraperitoneal injection at a dosage of 5 mg/kg for 10 days, particularly in conjunction with NBMPR-P, Tubercidin shields mice from its own lethal effects, enabling the treatment to be repeated with a 100% survival rate[3].
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