Tioxolone/噻克索酮
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货号：A436967
同义名：
Thioxolone
Tioxolone是一种金属酶碳酸酐酶 I 的抑制剂，Ki 为 91 nM，作为一种抗痤疮制剂。
Tioxolone/噻克索酮 化学结构
Tioxolone/噻克索酮 3D分子结构
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Tioxolone/噻克索酮 纯度/质量文件 产品仅供科研
货号：A436967
标准纯度：
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Tioxolone/噻克索酮 质控信息
Tioxolone/噻克索酮 生物活性
靶点
Carbonic Anhydrase I
CAI, Ki:91 nM
描述
Thioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters[3] [4] [5]
Tioxolone/噻克索酮 参考文献
[1] Kim BH, Min YS, et al. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Exp Mol Med. 2011 May 31;43(5):313-21.
[2] Byres M, Cox PJ. The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone). Acta Crystallogr C. 2004 Jun;60(Pt 6):o395-6.
[3] Barrese AA 3rd, Genis C, Fisher SZ, Orwenyo JN, Kumara MT, Dutta SK, Phillips E, Kiddle JJ, Tu C, Silverman DN, Govindasamy L, Agbandje-McKenna M, McKenna R, Tripp BC. Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry. 2008 Mar 11;47(10):3174-84
[4] Sippel KH, Genis C, Govindasamy L, Agbandje-McKenna M, Kiddle JJ, Tripp BC, McKenna R. Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. J Phys Chem Lett. 2010 Oct 7;1(19):2898-2902
[5] Innocenti A, Maresca A, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors? Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41
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Tioxolone/噻克索酮 实验方案
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摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
5.95mL
1.19mL
0.59mL
29.73mL
5.95mL
2.97mL
59.46mL
11.89mL
5.95mL
Tioxolone/噻克索酮 技术信息
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