Syringin is a natural product isolated and purified from the fruits of Syringa vulgaris with antitumour,antiproliferative, anti-inflammatory and antinociceptive effects.
Syringin/紫丁香酚苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
N2a cells
1 mM
6 h
To evaluate the protective effects of Syringin on N2a and APPswe cells under oxidative stress conditions. Results showed that Syringin pretreatment significantly reduced H2O2-induced ROS production and apoptosis, and improved cell cycle delay.
Syringin significantly reduced ATX II-prolonged APD90 and eliminated ATX II-induced EADs, DADs, and TAs.
Acta Pharmacol Sin. 2021 Feb;42(2):209-217.
Rabbit atrial myocytes
167 μM
Syringin concentration-dependently inhibited INaL, INaT, and ATX II-increased INaL with IC50 values of 167, 1582, and 181 μM, respectively.
Acta Pharmacol Sin. 2021 Feb;42(2):209-217.
MDA-MB-231 cells
0, 20, 40, 80, 160, and 320 µg/mL
24 h and 48 h
Syringin significantly inhibited the proliferation of MDA-MB-231 cells with an IC50 of 228.8 µg/mL (48 h).
J Transl Med. 2022 Jul 6;20(1):310.
MCF-7 cells
0, 20, 40, 80, 160, and 320 µg/mL
24 h and 48 h
Syringin significantly inhibited the proliferation of MCF-7 cells with an IC50 of 207.9 µg/mL (48 h).
J Transl Med. 2022 Jul 6;20(1):310.
SH-SY5Y cells
2-4 μM
24 h
SRG pretreatment dose-dependently reduced 6-OHDA-induced cell death, with 4 μM SRG increasing cell survival rate by 1.6-fold
Cells. 2023 Sep 19;12(18):2310.
NSC-34 mouse motor neuron cells
0.25-8 μM
24 h
Syringin improved PR-CM-induced motor neuron death and apoptosis
Cells. 2022 Oct 5;11(19):3128.
Syringin/紫丁香酚苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
APP/PS1 transgenic mice and wild-type C57BL/6 mice
Alzheimer's disease model
Oral gavage
20 mg/kg and 60 mg/kg
Once daily for five months
To evaluate the effects of Syringin on cognitive deficits and AD-related pathology in APP/PS1 mice. Results showed that Syringin treatment significantly improved cognitive function, reduced Aβ deposition, and enhanced synaptic plasticity in APP/PS1 mice.
Redox Biol. 2020 Sep;36:101672.
New Zealand white rabbits
Langendorff-perfused rabbit heart model
Perfusion
200 μM
100 minutes
EB substantially decreased ATX II-induced incidences of atrial fibrillation (AF), ventricular fibrillation (VF), and heart death.
Acta Pharmacol Sin. 2021 Feb;42(2):209-217.
Caenorhabditis elegans
BZ555 (Pdat-1::GFP), NL5901 (Punc-54::α-Syn::YFP), DA2123 (lgg-1p::GFP::lgg-1), and VC199 (sir2.1 (ok434))
Culture medium treatment
1 mM
Pretreatment for 24 hours, then exposed to 6-OHDA for 1 hour
SRG pretreatment ameliorated 6-OHDA-induced degeneration of DA neurons, dopamine-mediated food-sensitive behavioral abnormalities, and shortened lifespan, and enhanced autophagic activity by upregulating the sir-2.1 pathway
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