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植物固醇 其他化合物 MMP 胆固醇
/ Stigmasterol/豆甾醇

Stigmasterol/豆甾醇 {[allProObj[0].p_purity_real_show]}

货号：A284575 同义名： Stigmasterin; 5,22-Cholestadien-24-beta-ethyl-3-beta-ol

Stigmasterol是一种植物甾醇，具有抗癌、解热、抗炎和免疫调节作用，也被评估为降低 LDL 胆固醇的潜力成分。

Stigmasterol/豆甾醇 化学结构 CAS号：83-48-7
Stigmasterol/豆甾醇 化学结构
CAS号：83-48-7
Stigmasterol/豆甾醇 3D分子结构
CAS号：83-48-7
Stigmasterol/豆甾醇 化学结构 CAS号：83-48-7
Stigmasterol/豆甾醇 3D分子结构 CAS号：83-48-7
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Stigmasterol/豆甾醇 纯度/质量文件 产品仅供科研

货号：A284575 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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产品名称 MMP ↓ 其他靶点 纯度
Marimastat +++

MMP-7, IC50: 16 nM

MMP-14, IC50: 3 nM

 		98%
Ilomastat ++++

MMP-26, Ki: 0.36 nM

MMP-2, Ki: 0.1 nM

 		99%+
SB-3CT +

MMP-9, Ki: 600 nM

MMP-2, Ki: 13.9 nM

 		99%+
Doxycycline ✔ 95%
NSC 405020 ✔ 98%
Batimastat +++

MMP-7, IC50: 4 nM

MMP-1, IC50: 3 nM

 		99%+
Nobiletin ✔ 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Stigmasterol/豆甾醇 生物活性

描述 Stigmasterol, a natural compound isolated from Azadirachta indica, has many biological activities. In vitro studies, stigmasterol could induce apoptosis in hepatocarcimona (HepG2) cells by regulating the expression of some special genes. Besides this, it was found that stigmasterol could inhibit the activity of a partially purified bloodstream T. congolense sialidase with an inhibition binding constant of 356.59 μM. In vivo studies, stigmasterol could contribute to the improvement of skin tumors induced by 7,12-dimethylbenz[a]anthracene in swiss albino mice, possibly because of its oxidative stress response. In addition, stigmasterol has the ability of relieving some special skin inflammatory features in rodents.

Stigmasterol/豆甾醇 细胞实验

Cell Line
Concentration Treated Time Description References
B16F10 cells 0.5-50 µg/mL 1 hour To evaluate the inhibitory effect of STIG on H2O2-induced ROS levels. Results showed STIG significantly reduced H2O2-induced ROS levels. Antioxidants (Basel). 2024 Mar 21;13(3):380
LS174T human colon cancer cells 200 mM 16 hours Evaluate the activity of stigmasterol as an LXR agonist in human intestinal cells, results showed stigmasterol could induce the expression of LXR target gene ABCA1. J Nutr Biochem. 2020 Feb;76:108263
L6 cells 40 μg/mL 20 minutes Evaluate the effect of stigmasterol on GLUT4 translocation, results showed that stigmasterol treatment increased fluorescence intensity on L6 cell membranes, indicating enhanced GLUT4 translocation activity. Food Nutr Res. 2017 Aug 23;61(1):1364117
U87 GBM cells 10, 20, 40, 80, 120, 160, 200, 240 µM 24 and 48 hours Stigmasterol suppressed the proliferation of GBM cells in a dose- and time-dependent manner. Mol Med Rep. 2024 Dec;30(6):227
B16F10 cells 20 µg/mL 24 hours To evaluate the effect of STIG on PD-L1 expression. Results showed STIG significantly reduced IFN-γ-induced PD-L1 mRNA and protein levels. Antioxidants (Basel). 2024 Mar 21;13(3):380
L6 cells 10, 20, 40 μg/mL 24 hours Detect the effect of stigmasterol on glucose uptake, results showed that stigmasterol increased glucose uptake in a concentration-dependent manner. Food Nutr Res. 2017 Aug 23;61(1):1364117
RAW264.7 cells 15 µM 24 hours To investigate the effect of stigmasterol-treated LPS-induced Schwann cell-conditioned medium on the proliferation and migration of RAW264.7 cells. Results showed that L-S-CM significantly inhibited the proliferation and migration of RAW264.7 cells. CNS Neurosci Ther. 2024 Apr;30(4):e14657
RSC96 cells 15 µM 24 hours To investigate the effect of stigmasterol on IL-34 secretion in LPS-induced RSC96 cells. Results showed that stigmasterol significantly reduced the secretion of IL-34 in LPS-induced RSC96 cells. CNS Neurosci Ther. 2024 Apr;30(4):e14657
OV90 cells 0, 5, 10, 20 μg/mL 24 hours Induced apoptosis, activated caspase-3 and caspase-9 Pharmaceutics. 2020 May 28;12(6):488
ES2 cells 0, 5, 10, 20 μg/mL 24 hours Induced apoptosis, activated caspase-3 and caspase-9 Pharmaceutics. 2020 May 28;12(6):488
Ishikawa cells 10 μg/ml 24 hours Stigmasterol enhances the sensitivity of endometrial cancer cells to cisplatin by suppressing Nrf2 expression Antioxidants (Basel). 2022 Jan 20;11(2):199
Ishikawa cells 10 μg/ml 24 hours Stigmasterol enhances the sensitivity of endometrial cancer cells to cisplatin by suppressing Nrf2 expression Cancer Cell Int. 2020 Oct 6;20:480
U87 GBM cells 240 µM 24 hours Stigmasterol significantly reduced free fatty acid and total cholesterol levels in U87 GBM cells. Mol Med Rep. 2024 Dec;30(6):227
U87 GBM cells 240 µM 24 hours Stigmasterol significantly inhibited vasculogenic mimicry formation in U87 GBM cells. Mol Med Rep. 2024 Dec;30(6):227
U87 GBM cells 240 µM 24 hours Stigmasterol significantly inhibited the migration ability of U87 GBM cells. Mol Med Rep. 2024 Dec;30(6):227
U87 GBM cells 240 µM 24 hours Stigmasterol significantly reduced the number of invasive U87 GBM cells. Mol Med Rep. 2024 Dec;30(6):227
U87 GBM cells 240 µM 24 hours Stigmasterol significantly increased the proportion of apoptotic U87 GBM cells. Mol Med Rep. 2024 Dec;30(6):227
4T1 isolated breast cancer stem-like cells 0, 1, 5, 10 µM 24 hours Inhibits spheroid formation ability, cell viability, and migration ability, promotes cell apoptosis J Cancer. 2025 Feb 3;16(5):1618-1630
SUM159 isolated breast cancer stem-like cells 0, 1, 5, 10 µM 24 hours Inhibits spheroid formation ability, cell viability, and migration ability, promotes cell apoptosis J Cancer. 2025 Feb 3;16(5):1618-1630
Mouse chondrogenic cells (ATDC5 cells) 5, 10, 20, 40 μg/mL 24 hours To detect the effect of stigmasterol on the viability of ATDC5 cells, the results showed that 0-20 μg/ml STM had no significant effect on cell viability, while 40 μg/ml STM showed inhibitory effects. Bioengineered. 2021 Dec;12(2):9332-9340
Liver epithelial cells THLE-2 10, 50, 100 µg/mL 48 hours Assessed cytotoxicity and metabolic activity, showing DP3SSt inhibited cell proliferation and viability at 50 and 100 µg/mL, while other derivatives had no significant effect Sci Rep. 2023 Dec 4;13(1):21375
Colon mucosa cells CCD 841CoN 10, 50, 100 µg/mL 48 hours Assessed cytotoxicity and metabolic activity, showing no toxicity from unheated and heated Stigmasterol derivatives, with DO3SSt promoting cell proliferation at specific concentrations Sci Rep. 2023 Dec 4;13(1):21375
Small intestine epithelial cells FHS 74Int 10, 50, 100 µg/mL 48 hours Assessed cytotoxicity and metabolic activity, showing no toxicity from unheated and heated Stigmasterol derivatives, with DO3SSt promoting cell proliferation at specific concentrations Sci Rep. 2023 Dec 4;13(1):21375
MGC-803 10, 20 µM 48 hours To evaluate the effect of Stigmasterol on cell proliferation, results showed that Stigmasterol significantly inhibited cell viability in a time- and dose-dependent manner in MGC-803 cells. Front Oncol. 2021 Feb 23;11:629008
SGC-7901 10, 20 µM 48 hours To evaluate the effect of Stigmasterol on cell proliferation, results showed that Stigmasterol significantly inhibited cell viability in a time- and dose-dependent manner in SGC-7901 cells. Front Oncol. 2021 Feb 23;11:629008
OV90 cells 0, 5, 10, 20 μg/mL 48 hours Increased mitochondrial depolarization, ROS production, and calcium overload Pharmaceutics. 2020 May 28;12(6):488
ES2 cells 0, 5, 10, 20 μg/mL 48 hours Increased mitochondrial depolarization, ROS production, and calcium overload Pharmaceutics. 2020 May 28;12(6):488
Human normal colon mucosa CCD 841 CoN cells 2.5, 5, 10, 20, 40 μg/mL 48 hours To assess the effect of stigmasterol on DNA synthesis. Results showed that non-heated stigmasterol at 5 μg/mL significantly inhibited DNA synthesis, and at 40 μg/mL decreased DNA synthesis by 61%. Heated stigmasterol at 20 and 40 μg/mL reduced DNA synthesis by 31% and 39%, respectively. Sci Rep. 2023 May 1;13(1):7093
Human normal colon mucosa CCD 841 CoN cells 1.25, 2.5, 5, 10, 20, 40 μg/mL 48 hours To evaluate the cytotoxicity of stigmasterol and its esters on colon mucosa cells. Results showed that non-heated stigmasterol at 40 μg/mL reduced viable cell number by approximately 80%, while heated stigmasterol showed lower cytotoxicity at the same concentration. Sci Rep. 2023 May 1;13(1):7093
RAW 264.7 cells 0, 1, 2.5, 5, 10 µM 48 hours To evaluate the effect of STG on the viability of RAW 264.7 cells. Results showed no significant change in cytotoxicity within concentrations ranging from 0 to 10 μM, but cellular viability decreased at 20 μM. Front Pharmacol. 2024 Dec 16;15:1527494
BEAS-2B cells 10 μg/mL and 20 μg/mL 48 hours To verify the anti-inflammatory and antioxidant stress effects of stigmasterol and to reduce NK1-R expression in IL-13-induced BEAS-2B cells. Pharm Biol. 2023 Dec;61(1):449-458
RAW 264.7 cells 5, 10 µM 6-7 days To evaluate the effect of STG on osteoclast-specific gene expression. Results showed that STG significantly downregulated the expression of Acp5, NFATc1, c-Fos, and CTSK genes. Front Pharmacol. 2024 Dec 16;15:1527494
RAW 264.7 cells 0, 1, 2.5, 5, 10 µM 6-7 days To assess the effect of STG on RANKL-induced osteoclast differentiation. Results showed that STG significantly inhibited osteoclast formation in a dose-dependent manner. Front Pharmacol. 2024 Dec 16;15:1527494

Stigmasterol/豆甾醇 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice High cholesterol diet model Oral 0.3% (w/w) 4 consecutive days Assess the effect of stigmasterol on cholesterol balance and secretion, results showed stigmasterol promoted intestinal cholesterol secretion but did not depend on LXR activation pathway. J Nutr Biochem. 2020 Feb;76:108263
C57BL/6J male mice DSS-induced colitis model Oral via diet 0.4% diet supplementation Fed for 1 week followed by 1.5% DSS in drinking water for 5 days To evaluate the protective effects of Stigmasterol against DSS-induced colitis. Results showed that Stigmasterol significantly inhibited colon shortening, reduced fecal hemoglobin content, decreased colonic inflammation score, and downregulated the expression of NF-κB, COX-2, and CSF-1. Food Funct. 2017 Nov 15;8(11):4179-4186
Mice High-fat western-style diet-induced NAFLD model Diet 0.4% in diet 17 weeks To investigate the effects of stigmasterol and β-sitosterol on high-fat western-style diet-induced NAFLD. Results showed that stigmasterol significantly ameliorated HFWD-induced fatty liver and metabolic abnormalities, including elevated levels of hepatic total lipids, triacylglycerols, cholesterol and liver histopathology. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1274-1284
BALB/C nude mice Breast cancer stem cell transplantation model Mammary fat pad injection 10 mg/kg Once a week for 1.5 months Significantly inhibits tumor formation ability and reverses its inhibitory effect by suppressing JAK3 expression J Cancer. 2025 Feb 3;16(5):1618-1630
C57BL/6J mice OVA-induced asthma mouse model Intraperitoneal injection 100 mg/kg 7 consecutive days To evaluate the anti-inflammatory and antioxidant stress effects of stigmasterol in OVA-induced asthma mice and to verify the role of NK1-R as a potential target. Pharm Biol. 2023 Dec;61(1):449-458
Wistar rats Cerebral ischemia/reperfusion injury model Oral 20, 40, 80 mg/kg 1 week Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats. Biosci Rep. 2020 Apr 30;40(4):BSR20192133
C57/BL6 male mice OVA-induced asthma mouse model Oral 5 mg/kg, 10 mg/kg, 20 mg/kg Every 2 days from day 21 to day 43 Stigmasterol alleviated OVA-induced airway inflammation, reduced the number of inflammatory cells in BALF, decreased levels of IL-1β, IL-5, IL-6, and IL-13, and inhibited the TGF-β1/Smad2 and IL-17A signaling pathways Aging (Albany NY). 2024 Apr 4;16(7):6478-6487
C57BL/6J female mice Ovariectomy (OVX) osteoporosis model Oral 5, 10 mg/kg Administered every other day for 8 weeks To evaluate the protective effect of STG against OVX-induced osteoporosis. Results showed that STG significantly reduced the number and surface area of osteoclasts and effectively prevented bone loss. Front Pharmacol. 2024 Dec 16;15:1527494
KK-Ay mice High-fat diet-induced type 2 diabetes model Oral 50 mg/kg/day, 100 mg/kg/day Once daily for 4 weeks Evaluate the hypoglycemic effect of stigmasterol in type 2 diabetic mice, results showed that stigmasterol significantly reduced fasting blood glucose levels and improved insulin resistance and oral glucose tolerance. Food Nutr Res. 2017 Aug 23;61(1):1364117
Sprague-Dawley rats Chronic constriction injury (CCI) model Oral gavage 80 mg/kg Once daily for 21 days To investigate the effect of stigmasterol on neuropathic pain in CCI rats. Results showed that stigmasterol significantly reduced thermal and cold hyperalgesia in CCI rats and decreased the levels of IL-1β, IL-6, TNF-α, CCL2, SP, and PGE2 in serum. CNS Neurosci Ther. 2024 Apr;30(4):e14657
Sprague-Dawley (SD) rats High-fat diet (HFD)-induced hyperlipidemia and hepatic steatosis model Intragastric administration Low-dose group: 100 mg/kg; High-dose group: 200 mg/kg Daily administration for 4 weeks ST treatment significantly alleviated HFD-induced hyperlipidemia and hepatic fat deposition, mainly dependent on the bile acid metabolic pathway. ST also improved intestinal barrier function and gut microbiota in HFD-fed rats, resulting in changes in bile acid metabolism. NPJ Sci Food. 2022 Aug 27;6(1):38

Stigmasterol/豆甾醇 动物研究

Dose Rat: 20 mg/kg - 80 mg/kg[5] (i.p.); 10 mg/kg - 300 mg/kg[6] (p.o.) Mice: 10 mg/kg - 100 mg/kg[7] (i.p.); 50 mg/kg - 200 mg/kg[7] (p.o.)
Administration i.p., p.o.

Stigmasterol/豆甾醇 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00698256 Hypercholesterolemia Not Applicable Completed - Finland ... 展开 >> University of kuopio Kuopio, Finland, 70211 收起 <<
NCT02702947 BPH Phase 4 Completed - India ... 展开 >> Department of Urology, King George's Medical University, Lucknow, UP, India Lucknow, Uttar Pradesh, India, 226003 收起 <<
NCT00718796 Cardiovascular Disease Phase 3 Completed - Canada, Ontario ... 展开 >> Canadian College of Naturopathic Medicine Toronto, Ontario, Canada, M2K 1E2 收起 <<

Stigmasterol/豆甾醇 参考文献

[1]Ali H, Dixit S, et al. Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma. Drug Des Devel Ther. 2015.

[2]Kim YS, Li XF, et al. Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells. BMB Rep. 2014 Aug;47(8):433-8.

[3]Aminu R, Umar IA, et al. Stigmasterol retards the proliferation and pathological features of Trypanosoma congolense infection in rats and inhibits trypanosomal sialidase in vitro and in silico. Biomed Pharmacother. 2017.

[4]Antwi AO, Obiri DD, et al. Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents. Biomed Res Int. 2018.

Stigmasterol/豆甾醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.23mL

4.85mL

2.42mL

Stigmasterol/豆甾醇 技术信息

CAS号83-48-7
分子式C29H48O
分子量 412.69
SMILES Code CC[C@](C(C)C)([H])/C([H])=C([H])/[C@@]([C@@]1([H])CC[C@@]2([H])[C@]([C@]3([H])CC[C@]12C)([H])CC=C4C[C@](O)([H])CC[C@@]43C)([H])C
MDL No. MFCD00003630
别名 Stigmasterin; 5,22-Cholestadien-24-beta-ethyl-3-beta-ol
运输蓝冰
InChI Key HCXVJBMSMIARIN-PHZDYDNGSA-N
Pubchem ID 5280794
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C
溶解方案

DMF: 1 mg/mL(2.42 mM)，配合低频超声，并水浴加热至45℃助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一
方案 二

Tags: Stigmasterol | 83-48-7 | Stigmasterin | MMP | Metabolic Enzyme/Protease | MMP | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Stigmasterol/豆甾醇 纯度/质量文件 | Stigmasterol/豆甾醇 亚型比较 | Stigmasterol/豆甾醇 生物活性 | Stigmasterol/豆甾醇 动物研究 | Stigmasterol/豆甾醇 临床数据 | Stigmasterol/豆甾醇 参考文献 | Stigmasterol/豆甾醇 实验方案 | Stigmasterol/豆甾醇 技术信息

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