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Doxycycline/多西环素 {[allProObj[0].p_purity_real_show]}

货号：A587145 同义名： 强力霉素 / Vibramycin; Doxiciclina

Doxycycline is an antibiotic that is used in the treatment of various infections caused by bacteria and protozoa.

Doxycycline/多西环素 化学结构 CAS号：564-25-0
Doxycycline/多西环素 化学结构
CAS号：564-25-0
Doxycycline/多西环素 3D分子结构
CAS号：564-25-0
Doxycycline/多西环素 化学结构 CAS号：564-25-0
Doxycycline/多西环素 3D分子结构 CAS号：564-25-0
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Doxycycline/多西环素 纯度/质量文件 产品仅供科研

货号：A587145 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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Doxycycline/多西环素 生物活性

靶点

  • MMP
描述 Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline doses commonly used with inducible expression systems (0.01-1 µg/mL) substantially alter cellular metabolism: mitochondrial protein synthesis was inhibited accompanied by reduced oxygen and increased glucose consumption. Furthermore, doxycycline protected human glioma cells from hypoxia-induced cell death. An impairment of cell growth was only detectable with higher doxycycline doses (10 µg/mL)[2]. Doxycycline had a deleterious effect on control groups and positive action for bone organization on female rats affected by bilateral ovariectomy-induced osteopenia and sedentary lifestyle[3]. The treatment with doxycycline and tocopherol alone and in combination significantly attenuated locomotor activity, memory recognition, reduced neuroinflammation, preserved oxidative balance, and restored the level of neurotransmitters[4]. Doxycycline caused certain fetal abnormalities, so it is advisable to avoid using this drug during pregnancy[5].

Doxycycline/多西环素 细胞实验

Cell Line
Concentration Treated Time Description References
JH-2-002 300 ng/ml 72 hours To evaluate the effect of PTPN11 knockdown on ERK signaling pathway, results showed that PTPN11 knockdown led to global suppression of ERK signaling pathway. Sci Adv. 2023 Nov 24;9(47):eadg8876.
ST8814 300 ng/ml 2 weeks To evaluate the effect of PTPN11 knockdown on MPNST cell growth, results showed that PTPN11 genetic depletion significantly reduced MPNST cell growth. Sci Adv. 2023 Nov 24;9(47):eadg8876.
Rosa26-rtTA-M2 mouse embryonic fibroblasts 2 μg/ml 4 days Evaluate the knockdown efficacy of Rpa3 shRNA in TRMPV vectors, showing effective suppression of Rpa3 expression in the presence of doxycycline. Nat Biotechnol. 2011 Jan;29(1):79-83.
ND1 mutant cells 1 μM 48 hours Evaluate effects of tetracycline analogs on ND1 mutant cell survival, partial analogs rescued cell death via selective inhibition of mitochondrial translation Nat Metab. 2021 Jan;3(1):33-42.
Intestinal epithelial cells 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Macrophages 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Pro-B cells 2 μg/ml 12-14 days Generated iPSC lines expressing pluripotency markers AP and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Mesenchymal stem cells (MSCs) 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Liver cells 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Keratinocytes 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Tail tip fibroblasts (TTF) 2 μg/ml 12-16 days Generated iPSC lines expressing pluripotency markers AP, SSEA1, and Nanog Nat Methods. 2010 Jan;7(1):56-9.
Mouse embryonic fibroblasts (MEFs) 2 μg/ml 2-4 weeks Generated iPSC lines expressing pluripotency markers alkaline phosphatase (AP), SSEA1, and reactivated endogenous Nanog locus as detected by immunostaining Nat Methods. 2010 Jan;7(1):56-9.

Doxycycline/多西环素 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Transgenic mice Transgenic mice with platelet-specific expression of cP2Y12 Drinking water 0.2 mg/mL Changed every 3 to 4 days for 2-3 weeks Evaluate the role of cP2Y12 in platelet activation, thrombosis, and the inverse agonist activity of AR-C78511 J Thromb Haemost. 2012 Oct;10(10):2149-57
Mice Acute myeloid leukemia (AML) model Oral 2 mg/ml (drinking water) and 625 mg/kg (food) Continuous administration from disease onset Evaluate the therapeutic effect of TRMPV-shRpa3 in AML model, showing that doxycycline-induced shRpa3 expression significantly delayed disease progression and improved survival. Nat Biotechnol. 2011 Jan;29(1):79-83.
Mice Ndufs4−/− mouse model Dietary supplementation 5000 ppm or 8000 ppm Continuous administration until endpoint Evaluate therapeutic effects of doxycycline in Leigh syndrome mouse model, significantly extended lifespan and ameliorated neuropathology Nat Metab. 2021 Jan;3(1):33-42.
Mouse NmycTRE/TRE:tTS mice Drinking water 2 mg/ml From E0.5d for 10 days Inducible and reversible regulation of endogenous Nmyc gene expression by the tTS-dox system, blocking Nmyc expression resulted in embryonic lethality at E11.5d, which could be rescued by dox administration. Nucleic Acids Res. 2012 Nov;40(21):e166
Balb/c nude mice Subcutaneous xenograft model Oral 2 mg/ml Daily until tumours reached 1000 mm3 or maximum holding time of 12 weeks To evaluate the effect of SNRPD3 knockdown on tumor growth, results showed complete inhibition of tumor growth with SNRPD3 knockdown Oncogene. 2024 Jan;43(5):363-377

Doxycycline/多西环素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00177333 Abortion, Induced ... 展开 >> Vomiting 收起 << Phase 4 Completed - United States, Pennsylvania ... 展开 >> Magee-Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT02623959 Advanced Cancers ... 展开 >> Malignant Pleural Effusions 收起 << Not Applicable Terminated(Slow Accrual) - United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT03115177 Osteoarthritis Not Applicable Completed - United States, Illinois ... 展开 >> Rush University Medical Center Chicago, Illinois, United States, 60612 收起 <<

Doxycycline/多西环素 参考文献

[1]Briest W, Cooper TK, Tae HJ, Krawczyk M, McDonnell NB, Talan MI. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7

[2]Luger AL, Sauer B, Lorenz NI, Engel AL, Braun Y, Voss M, Harter PN, Steinbach JP, Ronellenfitsch MW. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504

[3]de Figueiredo FAT, Shimano RC, Ervolino E, Pitol DL, Gerlach RF, Issa JPM. Doxycycline reduces osteopenia in female rats. Sci Rep. 2019 Oct 25;9(1):15316

[4]Rana A, Singh S, Deshmukh R, Kumar A. Pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats. Brain Inj. 2020 Jul 2;34(8):1039-1050

[5]Abd-Allah ER, Abd El-Rahman HA. Influence of doxycycline administration on rat embryonic development during organogenesis. J Biochem Mol Toxicol. 2021 Jan;35(1):e2261

Doxycycline/多西环素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.23mL

11.25mL

2.25mL

1.13mL

22.50mL

4.50mL

2.25mL

Doxycycline/多西环素 技术信息

CAS号564-25-0
分子式C22H24N2O8
分子量 444.43
SMILES Code O=C(C1=C(O)[C@@H](N(C)C)[C@@]([C@@H](O)[C@@]2([H])C(C(C3=C(O)C=CC=C3[C@@H]2C)=O)=C4O)([H])[C@@]4(O)C1=O)N
MDL No. MFCD00800994
别名 强力霉素 ;Vibramycin; Doxiciclina; Doxycyclinum; Doxytetracycline
运输蓝冰
InChI Key SGKRLCUYIXIAHR-AKNGSSGZSA-N
Pubchem ID 54671203
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 105 mg/mL(236.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Doxycycline | 564-25-0 | MMP Inhibitor | Induced Disease Models Products | Metabolic Enzyme/Protease | Anti-infection | Genetically Engineered Disease Models | MMP | Bacterial | Antibiotic | Parasite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Doxycycline/多西环素 纯度/质量文件 | Doxycycline/多西环素 生物活性 | Doxycycline/多西环素 临床数据 | Doxycycline/多西环素 参考文献 | Doxycycline/多西环素 实验方案 | Doxycycline/多西环素 技术信息

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