Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill and shows anticancer-effects in human leukemia U937 cells.
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Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill and shows anticancer-effects in human leukemia U937 cells.
Schisandrin C/五味子丙素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
THP-1 cells
20 µM
24 hours
To evaluate the activation of the cGAS-STING pathway by SC and its inhibitory effect on HBV replication. Results showed that SC significantly increased the phosphorylation of IRF3 and promoted IFN-β production, thereby inhibiting HBV replication.
Chin Med. 2024 Mar 18;19(1):48
Mouse C2C12 skeletal muscle cells
2.5 µM and 5 µM
24 hours
Schisandrin C enhanced glucose uptake at non-toxic concentrations and increased the protein expression of GLUT-4, IRS-1, AMPK, PI3K, and Akt.
Molecules. 2021 Oct 28;26(21):6509
Rat INS-1 pancreatic β-cells
2.5 µM and 5 µM
24 hours
Schisandrin C enhanced glucose-stimulated insulin secretion at non-toxic concentrations and increased the protein expression of PPARγ, PDX-1, IRS-2, PI3K, and Akt.
Molecules. 2021 Oct 28;26(21):6509
4T1 cells
15 µM
24 hours
Assess the cytotoxicity of SC on 4T1 cells, results showed SC exhibited minimal toxicity
Front Pharmacol. 2024 Aug 7;15:1369563
MC38 cells
15 µM
24 hours
Assess the cytotoxicity of SC on MC38 cells, results showed SC exhibited minimal toxicity
Front Pharmacol. 2024 Aug 7;15:1369563
HFL1 cells
20 µM, 40 µM, 80 µM
48 hours
To evaluate the inhibitory effects of Sch C on TGF-β1-induced differentiation and migration of HFL1 cells. Results showed Sch C significantly inhibited the expressions of α-SMA and FN, and reduced cell migration.
Sci Rep. 2023 Aug 18;13(1):13475
Schisandrin C/五味子丙素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
HBV infection model
Oral gavage
20 mg/kg
Continuous for 20 days
To evaluate the inhibitory effect of SC alone and in combination with Lut on HBV replication. Results showed that SC alone significantly reduced the levels of HBsAg, HBeAg, and HBV DNA in serum, and the effect was enhanced when combined with Lut.
Chin Med. 2024 Mar 18;19(1):48
ICR mice
BLM-induced pulmonary fibrosis model
Oral
50 mg/kg, 100 mg/kg, 200 mg/kg
Once daily for 28 days
To evaluate the protective effects of Sch C on BLM-induced pulmonary fibrosis. Results showed Sch C significantly improved pulmonary indexes, reduced ECM accumulation, and inhibited LOX expression.
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