STF-118804 is a highly specific NAMPT inhibitor, reducing the viability of most B-ALL cell lines with IC50 < 10 nM.
STF-118804 细胞实验
Cell Line
Concentration
Treated Time
Description
References
SU86.86
100 nM
48-72 hours
To evaluate the effect of STF-118804 on cell survival and growth, results showed that STF-118804 significantly reduced the viability of SU86.86 cells.
Oncotarget. 2017 Jun 29;8(49):85054-85067.
PaTu8988t
25 nM
48-72 hours
To evaluate the effect of STF-118804 on cell survival and growth, results showed that STF-118804 significantly reduced the viability of PaTu8988t cells.
Oncotarget. 2017 Jun 29;8(49):85054-85067.
Panc-1
25 nM
48-72 hours
To evaluate the effect of STF-118804 on cell survival and growth, results showed that STF-118804 significantly reduced the viability of Panc-1 cells.
Oncotarget. 2017 Jun 29;8(49):85054-85067.
NB1691 neurosphere cells
0.01nM and above
10 days
To evaluate the effect of STF-118804 on the self-renewal capacity of NB1691 neurosphere cells, results showed that STF-118804 at concentrations of 0.01nM and above significantly reduced neurosphere formation.
Front Oncol. 2022 Jun 23;12:883318.
NB1691 cells
10nM and above
24 and 48 hours
To evaluate the effect of STF-118804 on the viability of NB1691 cells, results showed that STF-118804 at concentrations of 10nM and above significantly reduced cell viability.
Front Oncol. 2022 Jun 23;12:883318.
CRC119 cells
100 nM
68 hours
Evaluate the effect of mycoplasma infection on resistance to NAMPT inhibitors
Cell Metab. 2020 Mar 3;31(3):564-579.e7.
H1299 cells
1 μM
48 hours
Screen for the effect of NAMPT inhibitors on cell viability
Cell Metab. 2020 Mar 3;31(3):564-579.e7.
CRC119-Hyor cells
100 nM
72 hours
Mycoplasma infection confers resistance to STF118804
Cell Metab. 2020 Mar 3;31(3):564-579.e7.
HCT116RFK866
28,500 nM
10 days
Evaluate the antiproliferative effect of STF-118804 on HCT116RFK866 cells, showing an EC50 of 28,500 nM and a resistance index of 1,447.
Oncotarget. 2018 Mar 27;9(23):16451-16461.
HCT116
19.7 nM
10 days
Evaluate the antiproliferative effect of STF-118804 on HCT116 cells, showing an EC50 of 19.7 nM.
Oncotarget. 2018 Mar 27;9(23):16451-16461.
STF-118804 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
Orthotopic pancreatic cancer model
Intraperitoneal injection
25 mg/kg
Twice daily for 20 days
To evaluate the anti-tumor effect of STF-118804 in vivo, results showed that STF-118804 significantly reduced tumor size and weight.
Oncotarget. 2017 Jun 29;8(49):85054-85067.
Nude mice
NB1691 xenograft model
Topical application
25mg/kg
Once daily for 2 weeks
To evaluate the effect of STF-118804 on tumor growth in the NB1691 xenograft model, results showed that STF-118804 significantly inhibited tumor growth.
Front Oncol. 2022 Jun 23;12:883318.
Nu/J mice
HCT116 xenograft tumor model
Subcutaneous injection
15 mg/kg or 30 mg/kg
Twice daily for 9-15 days
Evaluate the effect of mycoplasma infection on the antitumor efficacy of STF118804
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