STF-118804

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Chemical Structure| 894187-61-2 同义名 : -
CAS号 : 894187-61-2
货号 : A692427
分子式 : C25H23N3O4S
纯度 : 99%+
分子量 : 461.53
MDL号 : MFCD14918065
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(54.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • NAMPT
描述 STF-118804 is a highly specific NAMPT inhibitor, reducing the viability of most B-ALL cell lines with IC50 < 10 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL
参考文献

[1]Matheny CJ, Wei MC, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63.

[2]Espindola-Netto JM, Chini CCS, et al. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Jun 29;8(49):85054-85067.