Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
抗生素和抗病毒 肿瘤
/
抗感染
DNA损伤 细胞周期 结构 肿瘤表观遗传和基因调控
/
DNA
Antibacterial 大环内酯类
/ Rifapentine/利福喷丁

Rifapentine/利福喷丁 {[allProObj[0].p_purity_real_show]}

货号：A444634 同义名： DL 473; Cyclopentylrifampicin

Rifapentine 是一种通过抑制 DNA 依赖性 RNA 聚合酶发挥作用的抗菌化合物，常被用于结核病的研究。

Rifapentine/利福喷丁 化学结构 CAS号：61379-65-5
Rifapentine/利福喷丁 化学结构
CAS号：61379-65-5
Rifapentine/利福喷丁 3D分子结构
CAS号：61379-65-5
Rifapentine/利福喷丁 化学结构 CAS号：61379-65-5
Rifapentine/利福喷丁 3D分子结构 CAS号：61379-65-5
规格 价格 会员价 库存 数量
{[ item.pr_size ]} {[ size_append(item.pr_size_append, item.pr_am, item.pr_size) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Rifapentine/利福喷丁 纯度/质量文件 产品仅供科研

货号：A444634 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025, 188, (21): 5847-5861.e11. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025, 20, 1502-1513. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 95%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Rifapentine/利福喷丁 生物活性

描述 Rifapentine is an antibiotic compound used in the treatment of tuberculosis. Antibacterial Rifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme[3]. The 3-month isoniazid-rifapentine regimen is as safe and effective as other recommended latent tuberculosis infection regimens and achieves significantly higher treatment completion rates[4]. Indeed, rifapentine too may decrease blood levels of many oral antidiabetics and compete with them for protein-binding sites and/or transporters. Rifapentine seems to be more suitable for use in diabetes patients with renal impairment, owing to the fact that it does not cause renal toxicity, and it is eliminated via kidneys in smaller proportions than rifampicin[5]. Rifapentine can be administered twice weekly during the intensive phase of tuberculosis treatment and then once weekly during the continuation phase of treatment. Rifapentine is well tolerated, with most patients experiencing adverse effects at a similar rate as rifampin[6].

Rifapentine/利福喷丁 细胞实验

Cell Line
Concentration Treated Time Description References
Murine macrophages (J774 A.1) 0, 5, 25, 50 μg/mL 24 hours Evaluate the cytotoxicity of nanoparticles, results showed nanoparticles were non-toxic to macrophages with cell viability over 90%. Int J Nanomedicine. 2020 Oct 6;15:7491-7507.
Huh7 cells 0.5259 µM 48 hours Evaluate the inhibitory effect of rifapentine on YFV, results showed that rifapentine significantly inhibited YFV infection Emerg Microbes Infect. 2022 Dec;11(1):873-884.
A-498 cells 0.01 µg/mL 7 days To evaluate the inhibitory effect of rifapentine on Coxiella burnetii, results showed that rifapentine exhibited significant inhibitory effects in A-498 cells with an MIC of 0.01 µg mL−1. Microbiol Spectr. 2024 Jul 2;12(7):e0103424.
THP-1 cells ≤0.01 µg/mL 7 days To evaluate the inhibitory effect of rifapentine on Coxiella burnetii, results showed that rifapentine exhibited significant inhibitory effects in THP-1 cells with an MIC ≤0.01 µg mL−1. Microbiol Spectr. 2024 Jul 2;12(7):e0103424.
Mycobacterium tuberculosis 0.03 to 0.25 mg/L Evaluate the antimicrobial efficacy of rifapentine against M. tuberculosis, showing it is 2 to 10 times more potent than Rifampin Front Pharmacol. 2025 Jan 17;15:1463575.

Rifapentine/利福喷丁 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice Latent tuberculosis infection model Gavage 15 mg/kg Once weekly for 3 months To evaluate the efficacy of rifapentine combined with isoniazid or moxifloxacin for the treatment of latent tuberculosis infection, showing that 3-month once-weekly rifapentine-containing regimens were as active as 6-9 months of daily isoniazid Am J Respir Crit Care Med. 2005 Dec 1;172(11):1452-6
Mice Tuberculosis model Oral 15 mg/kg Once weekly for 4 months To evaluate the sterilizing activity of rifapentine in combination with moxifloxacin, results showed that once-weekly moxifloxacin plus rifapentine (15 mg/kg) was significantly more active than the predominantly twice-weekly Denver regimen Am J Respir Crit Care Med. 2005 Dec 1;172(11):1457-62
BALB/c mice Murine model of tuberculosis Oral 15 or 20 mg/kg Twice weekly for 4, 5, or 6 months To evaluate the bactericidal and sterilizing activities of rifapentine in tuberculosis treatment, results showed that twice-weekly rifapentine (15 or 20 mg/kg) regimens were more effective than standard daily therapy, achieving stable cure within 4 months. Am J Respir Crit Care Med. 2006 Jul 1;174(1):94-101
A129−/− mice YFV infection model Gavage 20 mg/kg/day Once daily for 21 days Evaluate the antiviral effect of rifapentine in YFV-infected mouse model, results showed that rifapentine significantly improved survival rate, alleviated clinical signs, and reduced virus load and injury in targeted organs Emerg Microbes Infect. 2022 Dec;11(1):873-884.

Rifapentine/利福喷丁 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02099240 Osteomyelitis Early Phase 1 Recruiting September 2019 United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD 收起 <<
NCT03474198 Tuberculosis, Pulmonary Phase 2 Phase 3 Recruiting March 12, 2022 Philippines ... 展开 >> De La Salle Health Sciences Institute Not yet recruiting Manila, Philippines Lung Center Philippines Recruiting Manila, Philippines Philippines Tuberculosis Society Incorporated (PTSI) Not yet recruiting Manila, Philippines Tropical Disease Foundation Not yet recruiting Manila, Philippines Singapore National University Hospital Not yet recruiting Singapore, Singapore Thailand King Chulalongkorn Memorial Hospital Not yet recruiting Bangkok, Thailand 收起 <<
NCT02689089 Tuberculosis Phase 4 Recruiting September 2019 Canada, Ontario ... 展开 >> The Ottawa Hospital - General Campus Recruiting Ottawa, Ontario, Canada, K1H 8L6 Contact: Gonzalo Alvarez, MD    613-737-8899    galvarez@ottawahospital.on.ca    Principal Investigator: Gonzalo Alvarez, MD, FRCPC 收起 <<

Rifapentine/利福喷丁 参考文献

[1]Temple ME, Nahata MC. Rifapentine: its role in the treatment of tuberculosis. Ann Pharmacother. 1999 Nov;33(11):1203-10.

[2]Jarvis B, Lamb HM. Rifapentine. Drugs. 1998 Oct;56(4):607-16; discussion 617.

[3]Sharma SK, Sharma A, Kadhiravan T, Tharyan P. Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB. Cochrane Database Syst Rev. 2013 Jul 5;2013(7):CD007545

[4]Njie GJ, Morris SB, Woodruff RY, Moro RN, Vernon AA, Borisov AS. Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis. Am J Prev Med. 2018 Aug;55(2):244-252

[5]Zheng C, Hu X, Zhao L, Hu M, Gao F. Clinical and pharmacological hallmarks of rifapentine's use in diabetes patients with active and latent tuberculosis: do we know enough? Drug Des Devel Ther. 2017 Oct 11;11:2957-2968

[6]Temple ME, Nahata MC. Rifapentine: its role in the treatment of tuberculosis. Ann Pharmacother. 1999 Nov;33(11):1203-10

Rifapentine/利福喷丁 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.14mL

0.23mL

0.11mL

5.70mL

1.14mL

0.57mL

11.40mL

2.28mL

1.14mL

Rifapentine/利福喷丁 技术信息

CAS号61379-65-5
分子式C47H64N4O12
分子量 877.03
SMILES Code O=C1[C@](C)(OC2=C1C3=C(C(O)=C(NC4=O)C(/C=N/N5CCN(C6CCCC6)CC5)=C3O)C(O)=C2C)O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](/C=C/C=C4/C)C)O)C)O)C)OC(C)=O)C)OC
MDL No. MFCD00866806
别名 DL 473; Cyclopentylrifampicin; R 773; MDL473
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(57.01 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一

Tags: Rifapentine | 61379-65-5 | DL 473 | Cyclopentylrifampicin | DL473 | DL-473 | Bacterial Inhibitor | Anti-infection | Antibiotic | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Rifapentine/利福喷丁 纯度/质量文件 | Rifapentine/利福喷丁 亚型比较 | Rifapentine/利福喷丁 生物活性 | Rifapentine/利福喷丁 临床数据 | Rifapentine/利福喷丁 参考文献 | Rifapentine/利福喷丁 实验方案 | Rifapentine/利福喷丁 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z