Rhapontin is a natural product isolated and purified from the roots of Rhei Rhizoma.
Rhapontin/土大黄苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HUVECs
1-100 µg/mL
24 hours
Evaluation of the effect of Rhapontin on HUVEC viability
Nutrients. 2023 Feb 14;15(4):949
HEp-2 cells
10, 20, 40 μg/mL
24 hours
Evaluate the cytotoxicity of Rhapontin on HEp-2 cells
Vet Res. 2025 Feb 4;56(1):26
HT1080 cells
25, 50, 100 µM
24 hours
To evaluate the effect of RA on MMP-9 activity in HT1080 cells, results showed RA markedly suppressed the PMA-induced increase in MMP-9 activity.
Int J Oncol. 2018 Sep;53(3):1160-1170
BEAS-2B cells
0–100 µM
24 hours
Evaluate the effect of Rhapontin on BEAS-2B cell proliferation, results showed Rhapontin had minimal impact on the proliferation of BEAS-2B cells
Front Mol Biosci. 2024 Jun 11;11:1413214
A549 cells
0–100 µM
24 hours
Evaluate the inhibitory effect of Rhapontin on A549 cell proliferation, results showed Rhapontin had a concentration-dependent proliferation inhibitory effect on A549 cells with an IC50 of 62 μM
Front Mol Biosci. 2024 Jun 11;11:1413214
HUVECs
25, 50, 100 µM
4-12 hours
To evaluate the effect of RA on tube formation in HUVECs, results showed RA significantly inhibited tube-like network formation.
Int J Oncol. 2018 Sep;53(3):1160-1170
CCRF-CEM
18.05 µM
48 hours
Evaluate the cytotoxic and apoptosis-inducing effects of Rhapontin on CCRF-CEM cell line. Results showed Rhapontin significantly reduced cell viability and induced apoptosis.
Molecules. 2019 May 17;24(10):1896
CEM/C1
51.54 µM
48 hours
Evaluate the cytotoxic and apoptosis-inducing effects of Rhapontin on CEM/C1 cell line. Results showed Rhapontin significantly reduced cell viability and induced apoptosis.
Molecules. 2019 May 17;24(10):1896
HL60/MX2
31.51 µM
48 hours
Evaluate the cytotoxic and apoptosis-inducing effects of Rhapontin on HL60/MX2 cell line. Results showed Rhapontin significantly reduced cell viability and induced apoptosis.
Molecules. 2019 May 17;24(10):1896
HL60/MX1
28.38 µM
48 hours
Evaluate the cytotoxic and apoptosis-inducing effects of Rhapontin on HL60/MX1 cell line. Results showed Rhapontin significantly reduced cell viability and induced apoptosis.
Molecules. 2019 May 17;24(10):1896
HL60
41.75 µM
48 hours
Evaluate the cytotoxic and apoptosis-inducing effects of Rhapontin on HL60 cell line. Results showed Rhapontin significantly reduced cell viability and induced apoptosis.
Molecules. 2019 May 17;24(10):1896
MDA-MB231 cells
25, 50, 100 µM
48 hours
To evaluate the effect of RA on colony formation in MDA-MB231 cells, results showed RA significantly inhibited anchorage-dependent colony formation.
Int J Oncol. 2018 Sep;53(3):1160-1170
Rhapontin/土大黄苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Galleria mellonella larvae
Streptococcus suis infection model
Injection
10, 20, 40 μg/mL
Single dose, observed for 72 hours
Evaluate the protective effect of Rhapontin on Galleria mellonella larvae infection
Vet Res. 2025 Feb 4;56(1):26
Chick embryos
Chick chorioallantoic membrane (CAM) model
Topical application
100 µg/embryo
Single dose, observed for 3 days
To evaluate the effect of RA on angiogenesis in the CAM model, results showed RA significantly inhibited spontaneous and VEGF-induced angiogenesis.
Int J Oncol. 2018 Sep;53(3):1160-1170
C57BL/6J mice
MPTP-induced Parkinson's disease model
Gavage
20 mg/kg/day
Once daily, throughout the experimental period
Rhapontin ameliorated MPTP-induced gastrointestinal dysfunction and motor symptoms in Parkinson's disease mice by activating NRF2.
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