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/ Raddeanin A/竹节香附素A

Raddeanin A/竹节香附素A {[allProObj[0].p_purity_real_show]}

货号：A114782 同义名： NSC382873; Raddeanin R3

Raddeanin A是一种来源于竹节香附的天然三萜皂苷，展示出显著的抗癌活性。它通过调控 ROS/JNK 和 NF-κB 信号通路，发挥对人类骨肉瘤的抗癌效应。此化合物在癌症治疗研究中具有潜在应用价值。

Raddeanin A/竹节香附素A 化学结构 CAS号：89412-79-3
Raddeanin A/竹节香附素A 化学结构
CAS号：89412-79-3
Raddeanin A/竹节香附素A 3D分子结构
CAS号：89412-79-3
Raddeanin A/竹节香附素A 化学结构 CAS号：89412-79-3
Raddeanin A/竹节香附素A 3D分子结构 CAS号：89412-79-3
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Raddeanin A/竹节香附素A 纯度/质量文件 产品仅供科研

货号：A114782 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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Raddeanin A/竹节香附素A 细胞实验

Cell Line
Concentration Treated Time Description References
HIBEpiC 0-160 μg/mL 24 hours RA showed lower toxicity to normal cells World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
RAW264.7 cells 0.8 µM 0, 10, 30 minutes RA significantly inhibited RANKL-induced phosphorylation of AKT. Cell Death Dis. 2018 Mar 7;9(3):376
SNU-1 cells 0, 2, 4, 8, 16 µM 12 hours RA effectively inhibited the proliferation of SNU-1 cells, with the inhibition rate rising to 86.26%±1.58% when the RA concentration reached 16 μM. J Tradit Complement Med. 2024 Jul 20;15(2):161-169
HGC-27 cells 0, 2, 4, 8, 16 µM 12 hours RA effectively inhibited the proliferation of HGC-27 cells, with the inhibition rate rising to 88.19%±0.34% when the RA concentration reached 16 μM. J Tradit Complement Med. 2024 Jul 20;15(2):161-169
22Rv1 cells 3 µM 12 hours To investigate the effect of RA on AR-V transcriptional activity, results showed that RA inhibited AR-V transactivating activity. J Cell Mol Med. 2019 May;23(5):3656-3664
B16-OVA cells 5 µM 20 hours RA significantly increased LacZ activity and IL-2, IFN-γ secretion, promoted DC maturation and CD8+ T cell activation Adv Sci (Weinh). 2023 May;10(13):e2206737
MC38 cells 5 µM 20 hours RA significantly increased HMGB1-Gluc activity and ATP release, upregulated CRT surface expression Adv Sci (Weinh). 2023 May;10(13):e2206737
B16 cells 5 µM 20 hours RA significantly increased HMGB1-Gluc activity and ATP release, upregulated CRT surface expression Adv Sci (Weinh). 2023 May;10(13):e2206737
U251 cells 50 nM and 100 nM 24 hours RA significantly inhibited the proliferation, migration, and invasion of U251 cells, and downregulated the expression of Skp2 and EMT-related proteins J Cancer. 2025 Jan 1;16(1):44-54
U87 cells 50 nM and 100 nM 24 hours RA significantly inhibited the proliferation, migration, and invasion of U87 cells, and downregulated the expression of Skp2 and EMT-related proteins J Cancer. 2025 Jan 1;16(1):44-54
MDA-MB-231 cells 6.25, 12.5 µM 24 hours RA significantly reduced proliferation and invasion of MDA-MB-231 cells. Cell Death Dis. 2018 Mar 7;9(3):376
U251 0-800 nM 24 hours RA inhibited the viability of GBM cell lines in a dose-dependent manner Int J Med Sci. 2021 Feb 4;18(7):1609-1617
U87 0-800 nM 24 hours RA inhibited the viability of GBM cell lines in a dose-dependent manner Int J Med Sci. 2021 Feb 4;18(7):1609-1617
LN299 0-800 nM 24 hours RA inhibited the viability of GBM cell lines in a dose-dependent manner Int J Med Sci. 2021 Feb 4;18(7):1609-1617
T98G 0-800 nM 24 hours RA inhibited the viability of GBM cell lines in a dose-dependent manner Int J Med Sci. 2021 Feb 4;18(7):1609-1617
MDA-MB-231 2–8 µM 24 hours RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels. Acta Pharmacol Sin. 2018 Apr;39(4):642-648
MCF-7 2–8 µM 24 hours RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels. Acta Pharmacol Sin. 2018 Apr;39(4):642-648
T47D 2–8 µM 24 hours RA dose-dependently enhanced autophagy, as evidenced by increased LC3 levels. Acta Pharmacol Sin. 2018 Apr;39(4):642-648
H1975 0, 1, 2, 4 µM 24 hours Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase. Transl Oncol. 2025 Jun;56:102382
HCC827 0, 1, 2, 4 µM 24 hours Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase. Transl Oncol. 2025 Jun;56:102382
PC-9 0, 1, 2, 4 µM 24 hours Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase. Transl Oncol. 2025 Jun;56:102382
A549 0, 1, 2, 4 µM 24 hours Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase. Transl Oncol. 2025 Jun;56:102382
H1299 0, 1, 2, 4 µM 24 hours Raddeanin A inhibits NSCLC cell survival, inhibits invasion and migration and causes cell cycle arrest in G1 phase. Transl Oncol. 2025 Jun;56:102382
Human osteosarcoma cells SJSA 2 µM 24 hours RA inhibited cell proliferation and induced apoptosis via ROS generation, which could be partially rescued by GSH pretreatment. Cancer Sci. 2019 May;110(5):1746-1759.
Human osteosarcoma cells 143B 2 µM 24 hours RA inhibited cell proliferation and induced apoptosis via ROS generation, which could be partially rescued by GSH pretreatment. Cancer Sci. 2019 May;110(5):1746-1759.
JEG-3/VP16 8 µM 24 hours RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis. J Cell Physiol. 2018 Jul;233(7):5370-5382
JEG-3/5-FU 8 µM 24 hours RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis. J Cell Physiol. 2018 Jul;233(7):5370-5382
JEG-3/MTX 8 µM 24 hours RA significantly suppressed STAT3 activation and NFIL3 protein expression in a dose-dependent manner and induced Caspase 3-dependent apoptosis. J Cell Physiol. 2018 Jul;233(7):5370-5382
NPC-039 cells 0.25, 0.5, 1 µM 24 hours Evaluate the effect of Raddeanin A on the apoptosis of NPC-039 cells. The results showed that Raddeanin A induced apoptosis in NPC-039 cells through both caspase-dependent and independent pathways. J Cell Mol Med. 2024 Aug;28(16):e70016
FaDu cells 0.25, 0.5, 1 µM 24 hours Evaluate the effect of Raddeanin A on the apoptosis of FaDu cells. The results showed that Raddeanin A induced apoptosis in FaDu cells through both caspase-dependent and independent pathways. J Cell Mol Med. 2024 Aug;28(16):e70016
K562 cells 0.25, 0.5, 1 µM 24 hours Evaluate the effect of Raddeanin A on the apoptosis of K562 cells. The results showed that Raddeanin A induced apoptosis in K562 cells through both caspase-dependent and independent pathways. J Cell Mol Med. 2024 Aug;28(16):e70016
22Rv1 cells 0-6 µM 24 hours To assess the effect of RA on the growth of CRPC cells, results showed that RA inhibited the growth of all AR-positive cells in a dose- and/or time-dependent manner. J Cell Mol Med. 2019 May;23(5):3656-3664
LICCF 0-160 μg/mL 24 hours RA reduced cell viability in a dose-dependent pattern World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
LIPF178C 0-160 μg/mL 24 hours RA reduced cell viability in a dose-dependent pattern World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
LIPF155C 0-160 μg/mL 24 hours RA reduced cell viability in a dose-dependent pattern World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
RBE 0-160 μg/mL 24 hours RA reduced cell viability in a dose-dependent pattern World J Gastroenterol. 2019 Jul 14;25(26):3380-3391
C-33A cells 0, 1, 2, 4, 6, 8 µM 24 hours and 48 hours RA significantly reduced the viability of c-33A cells and inhibited their invasion and migration abilities. Aging (Albany NY). 2021 Feb 17;13(5):7166-7179
Hela cells 0, 1, 2, 4, 6, 8 µM 24 hours and 48 hours RA significantly reduced the viability of Hela cells and inhibited their invasion and migration abilities. Aging (Albany NY). 2021 Feb 17;13(5):7166-7179
RPMI 8226 cells 6.091 µM (24 hours), 3.438 µM (48 hours) 24 hours, 48 hours To evaluate the inhibitory effect of RA on the proliferation of RPMI 8226 cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner Sci Rep. 2024 Nov 23;14(1):29061
MM.1R cells 3.905 µM (24 hours), 2.18 µM (48 hours) 24 hours, 48 hours To evaluate the inhibitory effect of RA on the proliferation of MM.1R cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner Sci Rep. 2024 Nov 23;14(1):29061
MM.1S cells 1.616 µM (24 hours), 1.058 µM (48 hours) 24 hours, 48 hours To evaluate the inhibitory effect of RA on the proliferation of MM.1S cells, results showed that RA inhibited cell proliferation in a time- and concentration-dependent manner Sci Rep. 2024 Nov 23;14(1):29061
MG63 3.977 ± 0.055 µM (IC50) 48 hours RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner Int J Biol Sci. 2019 Jan 24;15(3):668-679
U2OSR 6.510 ± 0.062 µM (IC50) 48 hours RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner Int J Biol Sci. 2019 Jan 24;15(3):668-679
U2OS 3.527 ± 0.018 µM (IC50) 48 hours RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner Int J Biol Sci. 2019 Jan 24;15(3):668-679
KHOSR 2.053 ± 0.086 µM (IC50) 48 hours RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner Int J Biol Sci. 2019 Jan 24;15(3):668-679
HOS 1.512 ± 0.034 µM (IC50) 48 hours RA inhibited cell proliferation and colony formation and induced apoptotic cell death in a dose-dependent manner Int J Biol Sci. 2019 Jan 24;15(3):668-679
GSCs (glioblastoma stem cells) 50 nM and 100 nM 5 days RA significantly inhibited the sphere-forming ability of GSCs and downregulated the expression of Skp2 and stemness markers (Sox2, Nestin) J Cancer. 2025 Jan 1;16(1):44-54
Bone marrow-derived macrophages (BMMs) 0, 0.2, 0.4, 0.8 µM 7 days RA inhibited RANKL-induced formation of TRAP-positive multinucleated osteoclasts in a concentration-dependent manner. Cell Death Dis. 2018 Mar 7;9(3):376
KHYG-1 cells 0.25, 0.5, 1 µM 72 hours Evaluate the effect of Raddeanin A on the proliferation of KHYG-1 cells. The results showed that Raddeanin A treatment significantly increased the cytotoxicity of KHYG-1 cells against K562 cells and increased IFN-γ secretion. J Cell Mol Med. 2024 Aug;28(16):e70016
C4-2 cells 3 µM 9 hours To investigate the effect of RA on AR transcriptional activity, results showed that RA inhibited AR-FL transactivating activity. J Cell Mol Med. 2019 May;23(5):3656-3664
Human osteosarcoma cell SJSA 2 μM 24 h RA inhibited cell proliferation and induced apoptosis through ROS generation Cancer Sci. 2019 May;110(5):1746-1759.
Human osteosarcoma cell 143B 2 μM 24 h RA inhibited cell proliferation and induced apoptosis through ROS generation Cancer Sci. 2019 May;110(5):1746-1759.

Raddeanin A/竹节香附素A 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c nude mice Nude mouse xenograft tumor model Intraperitoneal injection 0.5 mg/kg, 1.0 mg/kg Once every 2 days for 7 times over 30 days Raddeanin A also demonstrated an inhibitory effect on NSCLC tumor growth in a nude mouse xenograft tumor model. Transl Oncol. 2025 Jun;56:102382
C57BL/6 mice MC38 tumor model Intraperitoneal or intratumoral injection 1, 2, 4 mg/kg Four injections over 16 days RA significantly inhibited tumor growth and increased tumor-infiltrating CD8+ T cells and CD103+CD11c+ DCs Adv Sci (Weinh). 2023 May;10(13):e2206737
BALB/c nude mice Intracranial U87 xenograft model Intraperitoneal injection 100 mg/kg/day Once daily during the experiment RA inhibited tumor growth, prolonged survival time, downregulated the expression of β-catenin, EMT markers and VEGF, and decreased vessel density in vivo Int J Med Sci. 2021 Feb 4;18(7):1609-1617
BALB/c nude mice U87 subcutaneous xenograft model and intracranial xenograft model Intraperitoneal injection 100 mg/kg/day (subcutaneous model) and 200 mg/kg/day (intracranial model) Once daily for 20 days RA significantly inhibited the growth of U87 xenografts and downregulated the expression of Skp2, EMT markers, and stemness markers J Cancer. 2025 Jan 1;16(1):44-54
BALB/c nude mice SNU-1 xenograft tumor model Intraperitoneal injection 2 mg/kg, 4 mg/kg, 6 mg/kg Every other day for 35 days Both RA and PTX showed significant anti-tumor effects, but the combination of low-dose RA with PTX did not further enhance the anti-tumor effect. Neither RA nor paclitaxel significantly damaged the liver of tumor-bearing nude mice, and the combined use of RA and PTX did not increase the risk of liver injury. J Tradit Complement Med. 2024 Jul 20;15(2):161-169
BALB/c nude mice KHOSR tibia orthotopic tumor model Intraperitoneal injection 5 mg/kg Every 3 days for 7-10 treatments RA suppressed in vivo tumor growth and induced apoptosis Int J Biol Sci. 2019 Jan 24;15(3):668-679
BALB/c nude mice Orthotopic tibial osteosarcoma model Intraperitoneal injection 5 mg/kg and 10 mg/kg Every 3 days for 8 doses RA significantly inhibited tumor growth and induced apoptosis, with a 58% reduction in tumor weight at 10 mg/kg dose. Cancer Sci. 2019 May;110(5):1746-1759.
C57BL/6 mice Acute intracerebral hemorrhage model Intraperitoneal injection 50 mg/kg and 100 mg/kg Single dose 15 minutes after ICH induction RA significantly improved neurological behavioral scores in ICH mice, reduced the volume of intracerebral hematoma and cerebral edema, and reduced microglial infiltration around hemorrhagic lesions Int J Med Sci. 2022 Jul 11;19(8):1235-1240
C57BL/6 mice Ti-particle-induced calvarial osteolysis model Intraperitoneal injection 50 or 100 µg/kg/day Once daily for 14 days RA significantly reduced Ti-particle-induced osteolysis. Cell Death Dis. 2018 Mar 7;9(3):376
BALB/c athymic nude mice Tibial orthotopic osteosarcoma model Intraperitoneal injection 5 mg/kg and 10 mg/kg Every 3 days for 8 doses RA significantly inhibited tumor growth and induced apoptosis Cancer Sci. 2019 May;110(5):1746-1759.

Raddeanin A/竹节香附素A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.11mL

0.22mL

0.11mL

5.57mL

1.11mL

0.56mL

11.15mL

2.23mL

1.11mL

Raddeanin A/竹节香附素A 技术信息

CAS号89412-79-3
分子式C47H76O16
分子量 897.1
SMILES Code O=C([C@]12CCC(C)(C)C[C@@]1([H])C3=CC[C@]4([H])[C@@]5(C)CC[C@H](O[C@H]6[C@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@@H](O)CO6)C(C)(C)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC2)O
MDL No. MFCD10566637
别名 NSC382873; Raddeanin R3
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C
溶解方案

DMSO: 50 mg/mL(55.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Raddeanin A | 89412-79-3 | Apoptosis Inducer | Apoptosis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Raddeanin A/竹节香附素A 纯度/质量文件 | Raddeanin A/竹节香附素A 实验方案 | Raddeanin A/竹节香附素A 技术信息

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