Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
细胞生物学 生化试剂 天然产物 囊泡
/
细胞凋亡
类固醇 细胞凋亡 五加科 帕金森与阿尔茨海默症 细胞死亡
/
植物固醇
凋亡 细胞凋亡诱导剂 人参属
/ Protopanaxdiol/原人参二醇

Protopanaxdiol/原人参二醇

货号：A916196 同义名： 20 (S)-原人参二醇 / (20S)-Protopanaxadiol; 20-Epiprotopanaxadiol

Protopanaxdiol是人参皂苷的一种代谢衍生物，具有诱导凋亡的作用。

Protopanaxdiol/原人参二醇 化学结构 CAS号：30636-90-9
Protopanaxdiol/原人参二醇 化学结构
CAS号：30636-90-9
Protopanaxdiol/原人参二醇 3D分子结构
CAS号：30636-90-9
Protopanaxdiol/原人参二醇 化学结构 CAS号：30636-90-9
Protopanaxdiol/原人参二醇 3D分子结构 CAS号：30636-90-9
规格 价格 库存 数量
50μL*10mM(DMSO) ￥99随货￥69 咨询
100μL*10mM(DMSO) ￥109随货￥79 咨询
250μL*10mM(DMSO) ￥129随货￥99 咨询
500μL*10mM(DMSO) ￥239随货￥169 咨询
10mM*1mL(DMSO) ￥312 咨询
5mg ￥277 咨询
10mg ￥428 咨询
50mg ￥1436 咨询
购物车0 收藏 询单

Protopanaxdiol/原人参二醇 纯度/质量文件 产品仅供科研

货号：A916196 标准纯度：
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025, 188, (21): 5847-5861.e11. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025, 20, 1502-1513. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >

Protopanaxdiol/原人参二醇 生物活性

描述 (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin-apoptosis inducer. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant[3]. 20S-protopanaxadiol (PPD) showed the most potent cytotoxic activity in both LX-2 cells and primary activated HSCs (hepatic stellate cells) . In addition, 20S-PPD concentration-dependently increased the phosphorylation of AMPK, and compound C prevented 20S-PPD-induced cytotoxicity and mitochondrial dysfunction. Moreover, 20S-PPD increased the phosphorylation of liver kinase B1 (LKB1), an upstream kinase of AMPK. Likewise, transfection of LX-2 cells with LKB1 siRNA reduced the cytotoxic effect of 20S-PPD[4]. PPD (>30 μM) suppressed cell proliferation by arresting cell cycle in G0/1 phase and triggering cells apoptosis as shown by cell viability assay, flow cytometry analysis and colony formation assay, whereas lower dose of PPD (<20 μM) decreased metastatic potential of MDA-MB-231 and SUM159 cells through direct inhibition of cell adhesion, motility and invasiveness[5].

Protopanaxdiol/原人参二醇 细胞实验

Cell Line
Concentration Treated Time Description References
ectopic endometrial stromal cells (eESCs) 40 µM 48 hours To evaluate the effect of PPD on the expression of estrogen receptor α (ERα) and progesterone receptor α (PRα) in eESCs, results showed that PPD significantly decreased ERα expression and increased PRα expression. Cell Death Dis. 2018 May 1;9(5):574
ectopic endometrial stromal cells (eESCs) 40 µM 48 hours To evaluate the effect of PPD on autophagy in eESCs, results showed that PPD upregulated the expression of autophagy-related molecules LC3B-II and Beclin-1, and downregulated p62 expression. Cell Death Dis. 2018 May 1;9(5):574

Protopanaxdiol/原人参二醇 参考文献

[1]Wanderi C, Kim E, et al. Ginsenoside 20(S)-Protopanaxadiol Suppresses Viability of Human Glioblastoma Cells via Down-regulation of Cell Adhesion Proteins and Cell-cycle Arrest. Anticancer Res. 2016 Mar;36(3):925-32.

[2]Oh HA, Kim DE, Choi HJ, Kim NJ, Kim DH. Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice. Biol Pharm Bull. 2015;38(2):331-5.

[3]Liu GY, Bu X, Yan H, Jia WW. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64

[4]Park SM, Jung EH, Kim JK, Jegal KH, Park CA, Cho IJ, Kim SC. 20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation. J Ginseng Res. 2017 Jul;41(3):392-402

[5]Peng B, He R, Xu Q, Yang Y, Hu Q, Hou H, Liu X, Li J. Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway. Pharmacol Res. 2019 Apr;142:1-13

Protopanaxdiol/原人参二醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.85mL

2.17mL

1.09mL

21.70mL

4.34mL

2.17mL

Protopanaxdiol/原人参二醇 技术信息

CAS号30636-90-9
分子式C30H52O3
分子量 460.73
SMILES Code C[C@](CC[C@]1(C2(C)C)[H])([C@@]3(C)[C@]4([C@]([H])(CC3)[C@@](O)(CC/C=C(C)\C)C)[H])[C@@]([H])([C@@]1(C)CC[C@@H]2O)C[C@H]4O
MDL No. MFCD12032048
别名 20 (S)-原人参二醇 ;(20S)-Protopanaxadiol; 20-Epiprotopanaxadiol; 20S-Protopanaxadiol; 20(S)-Protopanaxadiol; 20(S)-APPD
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C

溶解方案

DMSO: 50 mg/mL(108.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一

Tags: (20S)-Protopanaxadiol | 30636-90-9 | 20-Epiprotopanaxadiol | 20(S)-APPD | Akt activity inhibitor | Membrane Transporter/Ion Channel | NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation | Apoptosis | P-glycoprotein | Reactive Oxygen Species | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Protopanaxdiol/原人参二醇 纯度/质量文件 | Protopanaxdiol/原人参二醇 生物活性 | Protopanaxdiol/原人参二醇 参考文献 | Protopanaxdiol/原人参二醇 实验方案 | Protopanaxdiol/原人参二醇 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z