There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
PD 169316 is a potent and selective p38 MAP kinase inhibitor. It blocked p38 enzyme activity activated by serum-starvation and apoptosis by approximately 80% in Rat-1 fibroblasts at concentration of 10μM. PD169316 at 5μM or higher abrogated signaling initiated by both TGFβ and Activin A, but not BMP4, in CaOV3 cells. PD169316 at 10μM blocked the apoptotic process induced upon LIF withdrawal, without impairing cell differentiation, in mouse ES cells, with decreased FGF-5 and increased Bcl-2 expression on RNA level observed post 3 days.
PD169316 was able to inhibit p38 activation in response to the isolation procedure as well as cytokine stimulation.
Ann Surg. 2001 Jan;233(1):124-33.
Canine islet cells
100 µM
1 hour
PD169316 was able to inhibit p38 activation in response to the isolation procedure as well as cytokine stimulation.
Ann Surg. 2001 Jan;233(1):124-33.
Rabbit lacrimal gland acinar cells
2 µM
30 minutes
To investigate the effect of p38 inhibition on LG secretion, results showed PD 169316 significantly decreased carbachol-induced secretion
Cell Mol Biol Lett. 2012 Mar;17(1):1-10.
HEK-293 cells
10 µM
30 minutes
To investigate the effect of PD169316 on SERT expression, results showed that PD169316 inhibited SERT insertion to the plasma membrane and reduced 5-HT uptake.
J Neurosci. 2005 Jan 5;25(1):29-41.
Rat midbrain synaptosomes
10 µM
30 minutes
To investigate the effect of PD169316 on 5-HT uptake, results showed that PD169316 significantly inhibited 5-HT uptake and reduced transport capacity (Vmax).
J Neurosci. 2005 Jan 5;25(1):29-41.
Bone-marrow derived macrophages (BMMs)
10 µM
4 hours
To investigate the effect of PD 169316 on IFN-γ-activated macrophage bactericidal activity, results showed that PD 169316 inhibited p38 MAPK-mediated autophagy and bactericidal activity.
Immunology. 2014 Jan;141(1):61-9.
RAW 264.7 cells
10 µM
4 hours
To investigate the effect of PD 169316 on IFN-γ-activated macrophage bactericidal activity, results showed that PD 169316 inhibited p38 MAPK-mediated autophagy and bactericidal activity.
Immunology. 2014 Jan;141(1):61-9.
Mouse mesenchymal limb bud cells
2 µM
from day 2 onwards
To investigate the role of p38 MAP kinases in hypertrophic chondrocyte differentiation. Results showed that PD169316 treatment markedly delayed the induction of alkaline phosphatase activity and matrix mineralization, and reduced the expression of hypertrophic marker genes such as collagen X, matrix metalloproteinase 13, and bone sialoprotein.
Biochem J. 2004 Feb 15;378(Pt 1):53-62.
Y79 cells
10 µM
PD169316 increased the sensitivity of Y79 cells to SN50-induced cell death
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