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Oridonin/冬凌草甲素
Oridonin/冬凌草甲素
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货号：A472649
同义名：
NSC-250682; Isodonol
Oridonin是一种抗肿瘤剂，是从红色马兜铃（Rabdosia rubescens）中纯化的二萜类化合物。Oridonin 通过共价键与 NLRP3 NACHT 域的半胱氨酸 279 发生反应，消除了 NLRP3-NEK7 的相互作用，抑制了随后的 NLRP3 炎症小体的激活。
Oridonin/冬凌草甲素 化学结构
Oridonin/冬凌草甲素 3D分子结构
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Oridonin/冬凌草甲素 纯度/质量文件 产品仅供科研
货号：A472649
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全球学术期刊中引用的产品
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Oridonin/冬凌草甲素 质控信息
Oridonin/冬凌草甲素 生物活性
描述
Oridonin, a diterpenoid isolated from medicinal herb Rabdosia rubescens, possesses potent antitumor effect. The IC50 values of Oridonin in MG-63, HOS, Saos-2 and U-2OS cells were 12.29 ± 1.02, 13.22 ± 0.86, 19.72 ± 0.75, and 19.56 ± 0.47 μM, respectively, after 24 h of treatment. In vitro , oridonin had a selectively inhibitory effect on osteosarcoma cells but not on normal cells[3] In vivo , oridonin exhibited potent inhibitory effects in both WT and mutated HL60/p210 clones[6]
Oridonin/冬凌草甲素 参考文献
[1] Ikezoe T, Yang Y, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther. 2005 Apr;4(4):578-86.
[2] Ikezoe T, Chen SS, et al. Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol. 2003 Oct;23(4):1187-93.
[3] Lu Y, Sun Y, Zhu J, Yu L, Jiang X, Zhang J, Dong X, Ma B, Zhang Q. Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway. Cell Death Dis. 2018 Jan 11;9(1):15. doi: 10.1038/s41419-017-0031-6. PMID: 29323103; PMCID: PMC5849031.
[4] Shi M, Lu XJ, Zhang J, et al. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016;7(16):22623-22631.
[5] He H, Jiang H, Chen Y, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9(1):2550. Published 2018 Jun 29.
[6] Huang H, Weng H, Dong B, Zhao P, Zhou H, Qu L. Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia. Sci Rep. 2017 Jan 27;7:41525. doi: 10.1038/srep41525. PMID: 28128329; PMCID: PMC5270248.
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Oridonin/冬凌草甲素 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.74mL
0.55mL
0.27mL
13.72mL
2.74mL
1.37mL
27.44mL
5.49mL
2.74mL
Oridonin/冬凌草甲素 技术信息
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