Oridonin

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Chemical Structure| 28957-04-2 同义名 : NSC-250682; Isodonol; Oridonine; Rubescenin
CAS号 : 28957-04-2
货号 : A472649
分子式 : C20H28O6
纯度 : 99%
分子量 : 364.43
MDL号 : MFCD00221762
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(164.64 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+20%PEG 300+water 12.5 mg/mL

生物活性
描述 Oridonin, a diterpenoid isolated from medicinal herb Rabdosia rubescens, possesses potent antitumor effect. The IC50 values of Oridonin in MG-63, HOS, Saos-2 and U-2OS cells were 12.29 ± 1.02, 13.22 ± 0.86, 19.72 ± 0.75, and 19.56 ± 0.47 μM, respectively, after 24 h of treatment. In vitro, oridonin had a selectively inhibitory effect on osteosarcoma cells but not on normal cells[3]. In vivo, oridonin exhibited potent inhibitory effects in both WT and mutated HL60/p210 clones[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.72mL

2.74mL

1.37mL

27.44mL

5.49mL

2.74mL
参考文献

[1]Ikezoe T, Yang Y, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther. 2005 Apr;4(4):578-86.

[2]Ikezoe T, Chen SS, et al. Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol. 2003 Oct;23(4):1187-93.

[3]Lu Y, Sun Y, Zhu J, Yu L, Jiang X, Zhang J, Dong X, Ma B, Zhang Q. Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway. Cell Death Dis. 2018 Jan 11;9(1):15. doi: 10.1038/s41419-017-0031-6. PMID: 29323103; PMCID: PMC5849031.

[4]Shi M, Lu XJ, Zhang J, et al. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016;7(16):22623-22631.

[5]He H, Jiang H, Chen Y, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9(1):2550. Published 2018 Jun 29.

[6]Huang H, Weng H, Dong B, Zhao P, Zhou H, Qu L. Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia. Sci Rep. 2017 Jan 27;7:41525. doi: 10.1038/srep41525. PMID: 28128329; PMCID: PMC5270248.