NSC-207895
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货号：A1153021
同义名：
XI-006; NSC 179940
NSC-207895是一种DNA损伤剂，具有抗癌活性并能激活p53。
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Type HazMat fee for 500 gram (Estimated) Excepted Quantity USD 0.00 Limited Quantity USD 15-60 Inaccessible (Haz class 6.1), Domestic USD 80+ Inaccessible (Haz class 6.1), International USD 150+ Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+ Accessible (Haz class 3, 4, 5 or 8), International USD 200+
NSC-207895 化学结构
NSC-207895 3D分子结构
规格
价格
会员价
库存
数量
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NSC-207895 纯度/质量文件 产品仅供科研
货号：A1153021
标准纯度：
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产品说明书
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NSC-207895 质控信息
NSC-207895 生物活性
描述
NSC-207895 (XI-006), a DNA damaging agent, serves as an anticancer agent and p53 activator[1] [2] [3]
体外研究
NSC-207895 (0.5 μM, 30 min), an MDM2 inhibitor, enhances p53 protein levels[2]
NSC-207895, an MDMX inhibitor, reduces MDMX expression in AML cells at both mRNA and protein levels[3]
NSC-207895 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HT1080 cells
5 µM
24 h
Inhibited MDMX expression
Mol Cancer Ther. 2011 Jan;10(1):69-79.
MCF-7 cells
5 µM
16 h
Activated p53 and induced pro-apoptotic gene expression
Mol Cancer Ther. 2011 Jan;10(1):69-79.
B6-2
7.29 μM
48 h
NSC207895 showed significant cytotoxic and antiproliferative effects in B6-2 cells
Sci Rep. 2021 Feb 3;11(1):2967.
HepT1
1.47 μM
48 h
NSC207895 showed significant cytotoxic and antiproliferative effects in HepT1 cells
Sci Rep. 2021 Feb 3;11(1):2967.
Huh-6
3.03 μM
48 h
NSC207895 showed significant cytotoxic and antiproliferative effects in Huh-6 cells
Sci Rep. 2021 Feb 3;11(1):2967.
HepG2
0.95 μM
48 h
NSC207895 showed significant cytotoxic and antiproliferative effects in HepG2 cells
Sci Rep. 2021 Feb 3;11(1):2967.
Osteosarcoma cell lines
2.14–5.41 μM
48 h
XI-006 induced cell cycle arrest rather than apoptosis in osteosarcoma cell lines.
Sci Rep. 2015 Jun 22;5:11465.
Ewing sarcoma cell lines
0.099–1.61 μM
48 h
XI-006 induced potent p53-independent apoptosis in Ewing sarcoma cell lines, independent of MDM4 mRNA/protein levels or TP53 status.
Sci Rep. 2015 Jun 22;5:11465.
mouse primary chondrocytes
0.5 μM
6 h
NSC-207895 activates p53 and reverses the inhibitory effect of miR-325-3p on mechanical overloading-induced chondrocyte senescence.
Arthritis Res Ther. 2023 Apr 4;25(1):54.
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NSC-207895 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
HepT1 orthotopic xenograft model
Intraperitoneal injection
5 mg/kg
Every other day for three weeks
NSC207895 significantly decreased tumor weight and increased apoptosis in the treatment group
Sci Rep. 2021 Feb 3;11(1):2967.
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NSC-207895 参考文献
NSC-207895 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.58mL
0.72mL
0.36mL
17.91mL
3.58mL
1.79mL
35.81mL
7.16mL
3.58mL
NSC-207895 技术信息
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