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货号 产品名 纯度
A201732 现货 Pifithrin-α HBr

Pifithrin-α HBr是一种 p53 抑制剂,能阻断其转录活性并防止细胞凋亡。此外,它还是一种芳香烃受体 (AhR) 激动剂。

99%+
A124368 现货 Idasanutlin

Idasanutlin (RG7388) 是一种强效且选择性的 MDM2 拮抗剂,IC50 为 6 nM,能抑制 p53-MDM2 结合。

99%+
A520599 现货 RG7112

RG7112是一种高效、选择性、首个临床口服活性MDM2-p53抑制剂,可以穿过血脑屏障,IC50为18 nM,KD为11 nM,与MDM2结合。

99%+
A370437 现货 Pifithrin-μ/2-苯乙炔基-1-磺酰胺

Pifithrin-μ 是一种 p53HSP70 的抑制剂,具有抗肿瘤和神经保护作用。

99%+
A675515 现货 CP-31398 2HCl

CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

99%+
A755385 现货 PRIMA-1

PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.

98%
A326418 现货 Navtemadlin

AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).

98%
A1448615 现货 MS7972

99%+
A631504 现货 Eprenetapopt

APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

97%
A213189 现货 NSC319726

NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells.

99%+
A703883 现货 COTI-2

COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity.

99%+
A152615 现货 Tenovin-1

Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

98%
A536947 现货 PK11000

PK11007 is a p53 targeting compond anti-tumor activities.

99%
A385793 现货 Kevetrin HCl/盐酸凯维特林

Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity.

99%+
A603239 现货 Serdemetan

Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

99%+
A1153021 现货 NSC-207895

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

99%
A440096 现货 RITA

RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression.

99%+
A232907 现货 CBL0137 HCl/CBL0137盐酸

CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.

99%+
A1208571 现货 MIRA-1

97%
A1213296 现货 PK11007

PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53.

99%+
产品名 p53 其他靶点 纯度
Pifithrin-μ 99%+
Pifithrin-α HBr 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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