10-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent, has similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.

CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

Pifithrin-α HBr是一种 p53 抑制剂，能阻断其转录活性并防止细胞凋亡。此外，它还是一种芳香烃受体 (AhR) 激动剂。

NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells.

COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity.

Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

PK11007 is a p53 targeting compond anti-tumor activities.

PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.

Idasanutlin (RG7388) 是一种强效且选择性的 MDM2 拮抗剂，IC50 为 6 nM，能抑制 p53-MDM2 结合。

Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity.

Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

RG7112是一种高效、选择性、首个临床口服活性MDM2-p53抑制剂，可以穿过血脑屏障，IC50为18 nM，KD为11 nM，与MDM2结合。

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression.

AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).

CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.

MIRA-1是一种马来酰亚胺类似物，通过恢复p53依赖的转录激活功能，诱导p53突变细胞凋亡，具有显著的抗肿瘤活性，特别适用于p53突变型肿瘤的研究。

Pifithrin-μ 是一种 p53 和 HSP70 的抑制剂，具有抗肿瘤和神经保护作用。

PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53.