To investigate the effect of EMC on pre-osteoblast differentiation. EMC inhibited osteoblast differentiation induced by OS, reducing ALP staining and activity.
Int J Mol Sci. 2020 May 24;21(10):3700
Pre-osteoblast MC3T3-E1
10 and 30 µM
24 hours
To investigate the effect of EMC on pre-osteoblast migration. EMC significantly suppressed the cell migration rate.
Int J Mol Sci. 2020 May 24;21(10):3700
Pre-osteoblast MC3T3-E1
10 and 30 µM
24 hours
To investigate the effect of EMC on pre-osteoblast apoptosis. EMC significantly increased the cleaved forms of PARP and caspase-3 and decreased the expression levels of Survivin and Bcl-2.
Int J Mol Sci. 2020 May 24;21(10):3700
Pre-osteoblast MC3T3-E1
1, 10, 30, 100 µM
24 and 48 hours
To evaluate the effect of EMC on pre-osteoblast survival. EMC significantly inhibited cellular proliferation in a time- and dose-dependent manner.
Int J Mol Sci. 2020 May 24;21(10):3700
Peritoneal elucidated macrophages (PEMs)
25, 50, 100 μM
24 hours
To evaluate the inhibitory effect of methyl cinnamate on LPS-induced inflammatory response. Results showed that methyl cinnamate significantly reduced the expression levels of TNF-α, IL-1β, and IL-6.
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 25;55(11):1806-1818
RAW264.7 cells
25, 50, 100 μM
24 hours
To evaluate the inhibitory effect of methyl cinnamate on LPS-induced inflammatory response. Results showed that methyl cinnamate significantly reduced the expression levels of TNF-α, IL-1β, and IL-6.
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 25;55(11):1806-1818
HepG2 cells
100μM
24 hours
To study the effect of MC on lipid accumulation in HepG2 cells, results showed MC significantly reduced FFAs-induced lipid accumulation.
Diabetes Metab Syndr Obes. 2024 Mar 7;17:1183-1197
HepG2 cells
12.5, 25, 50, 100, 200, 400, 800μM
24, 48, 72 hours
To assess cell viability, results showed no significant changes in cell viability after 24 and 48 hours, but a significant decrease at 400μM and 800μM concentrations after 72 hours.
Diabetes Metab Syndr Obes. 2024 Mar 7;17:1183-1197
Methyl cinnamate/肉桂酸甲酯 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
DSS-induced colitis model
Oral
20 mg/kg, 40 mg/kg
Once daily for 14 days
To evaluate the therapeutic effects of methyl cinnamate on DSS-induced colitis. Results showed that methyl cinnamate significantly alleviated symptoms such as weight loss, increased disease activity index score, and colon shortening, and inhibited the overexpression of pro-inflammatory cytokines.
Acta Biochim Biophys Sin (Shanghai). 2023 Nov 25;55(11):1806-1818
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