Monobenzone is a compound used as a topical agent for medical depigmentation.
Monobenzone/莫诺苯宗 细胞实验
Cell Line
Concentration
Treated Time
Description
References
NB4 cells
18.04 ± 3.36 μM
72 hours
MB inhibited NB4 cell proliferation with an IC50 of 18.04 ± 3.36 μM.
Cancers (Basel). 2022 Sep 27;14(19):4710
MOLM13 cells
6.07 ± 1.55 μM
72 hours
MB inhibited MOLM13 cell proliferation with an IC50 of 6.07 ± 1.55 μM.
Cancers (Basel). 2022 Sep 27;14(19):4710
KG-1A cells
13.9 ± 1.64 μM
72 hours
MB inhibited KG-1A cell proliferation with an IC50 of 13.9 ± 1.64 μM.
Cancers (Basel). 2022 Sep 27;14(19):4710
Human primary melanocytes
5 μM
72 hours
To evaluate the effect of Monobenzone on melanin content. The results showed that Monobenzone significantly decreased melanin content in human primary melanocytes.
J Pharm Anal. 2024 Jan;14(1):69-85
MNT-1 cells
5 μM
72 hours
To evaluate the effect of Monobenzone on melanin content. The results showed that Monobenzone significantly decreased melanin content in MNT-1 melanoma cells.
J Pharm Anal. 2024 Jan;14(1):69-85
B16F10 cells
5 μM
72 hours
To evaluate the effect of Monobenzone on melanin content. The results showed that Monobenzone significantly decreased melanin content in B16F10 melanoma cells.
J Pharm Anal. 2024 Jan;14(1):69-85
Monobenzone/莫诺苯宗 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Monobenzone-induced depigmentation model
Topical application
40% (m/m)
Once daily for 54 days
To evaluate the effect of Monobenzone on dorsal hair color in mice. The results showed that Monobenzone significantly reduced pigmentation in the dorsal hair of mice.
J Pharm Anal. 2024 Jan;14(1):69-85
Mice
Monobenzone-induced vitiligo model
Topical application
40% monobenzone solution, 50 mg per day
Once daily for 45 days
To evaluate the therapeutic effects of taVNS in a mouse model of vitiligo, results showed that taVNS significantly alleviated symptoms, particularly by reducing the depigmented areas
Int J Mol Sci. 2024 Mar 18;25(6):3411
C57BL/6 mice
MBEH-induced vitiligo model
Topical application
40% (50 mg per day)
Once daily for two weeks, repeated for three rounds
MBEH significantly induced depigmentation in mice and increased the infiltration of CD8+ T cells in the skin.
Int J Mol Sci. 2023 Apr 10;24(8):6990
Nude mice
AML xenograft model
Intraperitoneal injection
150 or 200 mg/kg
Once daily for two weeks
MB significantly inhibited the growth of AML xenografts in nude mice with relatively low toxicity.
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