There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
MK-28 failed to protect PERK−/− cells from ER stress-induced apoptosis
Sci Rep. 2020 Apr 23;10(1):6875
STHdhQ7/7 cells
0-50 μM
48 hours
MK-28 significantly reduced apoptosis at 50 μM, similar to the effect in STHdhQ111/111 cells
Sci Rep. 2020 Apr 23;10(1):6875
STHdhQ111/111 cells
0-100 μM
48 hours
MK-28 significantly reduced ER stress-induced apoptosis, with a 5-fold reduction at 100 μM
Sci Rep. 2020 Apr 23;10(1):6875
MK-28 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
B6CBA-R6/2 (CAG 160+/−) and B6CBA-R6/2 (CAG 120+/−) mouse models
Intraperitoneal injection (IP)
0.1 mg/kg, 1 mg/kg, 10 mg/kg
3 times a week, starting at 3 weeks of age
To evaluate the long-term therapeutic effects of MK-28 in Huntington's disease model mice, results showed significant improvements in motor function, body weight recovery, blood glucose levels, and lifespan extension.
Neurotherapeutics. 2024 Mar;21(2):e00335
Mice
R6/2 HD model
Subcutaneous injection
1 mg/kg
Continuous for 28 days
MK-28 significantly improved motor and executive functions in R6/2 mice, delayed death onset, and extended median survival by 8 days
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