There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To evaluate the effect of Liensinine on RSL3-induced ferroptosis in AAM. Results showed that Liensinine increased cell viability in a dose-dependent manner, reduced LDH release, decreased Fe2+ and ROS levels, inhibited lipid oxidation product generation, and partially reversed mitochondrial damage.
Cell Death Discov. 2023 Jun 23;9(1):189
3T3-L1 mouse embryo fibroblasts
10, 20, 40 μM
5 days
To evaluate the effect of Liensinine on the maintenance of beige adipocytes, the results showed that Liensinine retained the characteristics of beige adipocytes by inhibiting mitophagy flux.
Nutrients. 2019 Jul 18;11(7):1640
Human pulmonary arterial endothelial cells (HPAECs)
20 μM
12 hours
To investigate the effect of Liensinine on mitophagy in hypoxia-induced HPAECs, results showed that Liensinine alleviated hypoxia-induced endothelial dysfunction by inhibiting mitophagy.
J Ginseng Res. 2025 Jan;49(1):80-91
human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs)
0.12 to 10 µM
24 hours
To evaluate the effect of Liensinine on hiPS-CMs contractility. Results showed that Liensinine mainly affected amplitude at high concentrations, and hiPS-CMs were more sensitive to Liensinine than neonatal rat cardiomyocytes.
Int J Mol Sci. 2016 Jan 29;17(2):186
primary neonatal rat cardiomyocytes
0.12 to 10 µM
24 hours
To evaluate the effect of Liensinine on cardiomyocyte contractility. Results showed that Liensinine significantly inhibited cardiomyocyte contractility at 3.3 and 10 µM, and the inhibition recovered over time.
Int J Mol Sci. 2016 Jan 29;17(2):186
pulmonary artery smooth muscle cells (PASMCs)
1, 2.5, 5, 10, 20 μM
48 hours
To evaluate the inhibitory effect of liensinine on hypoxia-induced proliferation and migration of PASMCs. Results showed that liensinine significantly inhibited hypoxia-induced proliferation and migration of PASMCs and reversed the upregulation of collagen1, collagen3, MMP2, MMP9, PCNA, PIM1, and p-SRC protein expression.
Front Pharmacol. 2022 Aug 17;13:977921
Liensinine/莲心碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
LPS/D-GalN-induced acute liver injury model
Intraperitoneal injection
10, 30, 60 mg/kg
Single dose, monitored for 24 hours
To evaluate the protective effect of Liensinine on LPS/D-GalN-induced acute liver injury. Results showed that Liensinine increased survival rate in a dose-dependent manner, reduced serum transaminase activity, alleviated liver pathological damage, suppressed inflammatory factor production, and increased AAM numbers.
Cell Death Discov. 2023 Jun 23;9(1):189
C57BL/6J mice
High-fat diet-induced obesity model
Intraperitoneal injection
60 mg/kg
Once daily for 15 days
To evaluate the effect of Liensinine on the maintenance of beige adipocytes, the results showed that Liensinine inhibited lysosomal cathepsin activity, blocked mitophagy flux, thereby retaining the molecular characteristics of beige adipocytes, reducing body weight gain rate and enhancing energy expenditure.
Nutrients. 2019 Jul 18;11(7):1640
C57BL/6 mice
LPS-induced sepsis model
Intraperitoneal injection
10, 20, and 40 mg/kg
Once daily for 5 days
To investigate the protective effects of Liensinine on sepsis-induced spleen injury, results showed that Liensinine significantly alleviated inflammatory response, oxidative stress, and apoptosis.
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