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细胞生物学 囊泡 肿瘤
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神经信号通路 免疫/炎症 细胞凋亡 帕金森与阿尔茨海默症 肿瘤发展和微环境演变 PPAR Signaling Pathway 细胞死亡
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细胞凋亡诱导剂
NLR 淀粉样蛋白-β 凋亡
/ Licochalcone B/甘草查尔酮 B

Licochalcone B/甘草查尔酮 B {[allProObj[0].p_purity_real_show]}

货号：A265326 同义名： Lico B

Licochalcone B提取自 Glycyrrhiza uralensis 根部，能有效抑制淀粉样蛋白 β (Aβ42) 的自聚集，并分解已形成的 Aβ42 原纤维。它通过螯合金属离子减少 Aβ42 聚集，并在 LPS 信号通路中抑制 NF-κB p65 磷酸化。此外，Licochalcone B 能抑制非小细胞肺癌 (NSCLC) 细胞的生长，诱导凋亡，并通过破坏 NEK7-NLRP3 相互作用来抑制 NLRP3 炎症小体。

Licochalcone B/甘草查尔酮 B 化学结构 CAS号：58749-23-8
Licochalcone B/甘草查尔酮 B 化学结构
CAS号：58749-23-8
Licochalcone B/甘草查尔酮 B 3D分子结构
CAS号：58749-23-8
Licochalcone B/甘草查尔酮 B 化学结构 CAS号：58749-23-8
Licochalcone B/甘草查尔酮 B 3D分子结构 CAS号：58749-23-8
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Licochalcone B/甘草查尔酮 B 纯度/质量文件 产品仅供科研

货号：A265326 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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Licochalcone B/甘草查尔酮 B 细胞实验

Cell Line
Concentration Treated Time Description References
THP-1 macrophages 10 μM 48 hours Evaluate the anti-inflammatory activity of Licochalcone B, showing significant inhibition of IL-1β P17 secretion in SFTSV-infected THP-1 macrophages. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2301775120
HaCaT 10, 20, 30 μM 48 hours LCB showed no significant toxicity to HaCaT cells. Antioxidants (Basel). 2023 Mar 7;12(3):656
JB6 10, 20, 30 μM 48 hours LCB showed no significant toxicity to JB6 cells. Antioxidants (Basel). 2023 Mar 7;12(3):656
Calu-3 cells 1.1, 3.3, 10, 30 μM 48 hours Evaluate the inhibitory effect of Licochalcone B on SARS-CoV-2-induced inflammatory responses, showing dose-dependent reduction of IL-1β P17 release. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2301775120
human liver microsomes 14.07 ± 1.55 μM 3 min or 33 min preincubation To evaluate the inhibitory effect of Licochalcone B on human CYP3A, results showed that Licochalcone B inhibited CYP3A in a time-dependent manner, with IC50 values decreasing from 14.07 μM to 6.81 μM. Acta Pharmacol Sin. 2022 Apr;43(4):1072-1081
A549 cells 139.70 μM 1 hour Evaluate the activity of Licochalcone B as a B2 receptor antagonist, results showed significant antagonist activity. J Ethnopharmacol. 2021 Nov 15;280:114488
HT-29 cells 25.12 μM 1 hour Evaluate the activity of Licochalcone B as a GPR35 agonist, results showed significant agonist activity. J Ethnopharmacol. 2021 Nov 15;280:114488
HCT116-OxR 10, 20, 30 μM 24 or 48 hours LCB significantly inhibited the viability of HCT116-OxR cells with an IC50 value of 26.86 μM. Antioxidants (Basel). 2023 Mar 7;12(3):656
HCT116 10, 20, 30 μM 24 or 48 hours LCB significantly inhibited the viability of HCT116 cells with an IC50 value of 25.21 μM. Antioxidants (Basel). 2023 Mar 7;12(3):656
human peripheral blood mononuclear cells (hPBMCs) 20 μM 1 hour To evaluate the effect of LicoB on NLRP3 inflammasome activation in hPBMCs, results showed inhibition of IL-1β secretion and caspase-1 cleavage EMBO Rep. 2022 Feb 3;23(2):e53499
PMA-differentiated THP-1 cells 20 μM 1 hour To evaluate the effect of LicoB on NLRP3 inflammasome activation in THP-1 cells, results showed inhibition of IL-1β secretion and caspase-1 cleavage EMBO Rep. 2022 Feb 3;23(2):e53499
mouse bone marrow-derived macrophages (BMDMs) 0-80 μM 24 hours To evaluate the cytotoxicity of LicoB on BMDMs, results showed no cytotoxicity below 80 μM EMBO Rep. 2022 Feb 3;23(2):e53499
Human Pulmonary Microvascular Endothelial Cells (HPMECs) 400 ng/mL 48 hours Evaluate the protective effect of LCB against LPS-induced oxidative stress. LCB pretreatment significantly reduced LPS-induced ROS levels. Redox Rep. 2023 Dec;28(1):2243423
Human Pulmonary Microvascular Endothelial Cells (HPMECs) 0.1-0.7 μM 24 hours and 48 hours Evaluate the effect of LCB on cell viability and cytotoxicity in HPMECs. LCB significantly increased cell viability at concentrations of 0.1-0.7 μM, with the best effect at 400 nM. Redox Rep. 2023 Dec;28(1):2243423
RAW264.7 cells 0.25, 0.5, 0.75 µM 24 hours LCB alleviates BDE-47-induced apoptosis and oxidative stress in RAW264.7 cells by activating the Nrf2 pathway and inhibiting the NF-κB pathway. Antioxidants (Basel). 2024 Apr 10;13(4):445

Licochalcone B/甘草查尔酮 B 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice LPS-induced septic shock model Intraperitoneal injection 20 or 40 mg/kg Single dose, monitored for 72 hours To evaluate the protective effect of LicoB on LPS-induced septic shock, results showed dose-dependent improvement in mouse survival EMBO Rep. 2022 Feb 3;23(2):e53499
C57BL/6 male mice LPS-induced acute lung injury model Intraperitoneal injection 10 mg/kg, 20 mg/kg, 40 mg/kg Once daily for seven consecutive days Evaluate the protective effect of LCB against LPS-induced acute lung injury. LCB significantly reduced pulmonary edema and oxidative stress markers and improved inflammatory responses. Redox Rep. 2023 Dec;28(1):2243423
Mice DOX-induced AKI model Intraperitoneal injection 200 μM 10 minutes incubation Licochalcone B was identified as a potential inhibitor of PAI-1, inhibiting its activity by direct binding. Chin Med. 2024 Nov 1;19(1):152

Licochalcone B/甘草查尔酮 B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL

Licochalcone B/甘草查尔酮 B 技术信息

CAS号58749-23-8
分子式C16H14O5
分子量 286.28
SMILES Code O=C(C1=CC=C(O)C=C1)/C=C/C2=CC=C(O)C(O)=C2OC
MDL No. MFCD20527294
别名 Lico B
运输蓝冰
InChI Key DRDRYGIIYOPBBZ-XBXARRHUSA-N
Pubchem ID 5318999
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 85 mg/mL(296.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一

Tags: Licochalcone B | 58749-23-8 | Apoptosis Inducer | Neuronal Signaling | Apoptosis | Immunology/Inflammation | Amyloid-β | Apoptosis | NOD-like Receptor (NLR) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Licochalcone B/甘草查尔酮 B 纯度/质量文件 | Licochalcone B/甘草查尔酮 B 实验方案 | Licochalcone B/甘草查尔酮 B 技术信息

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