Evaluation of Isosilybin A's inhibitory effect on CYP3A-mediated midazolam 1'-hydroxylation activity, showing >50% inhibition at 100 μM.
Drug Metab Dispos. 2013 Sep;41(9):1662-70
human liver microsomes
100 μM
2 minutes
Evaluation of Isosilybin A's inhibitory effect on CYP3A-mediated midazolam 1'-hydroxylation activity, showing >50% inhibition at 100 μM.
Drug Metab Dispos. 2013 Sep;41(9):1662-70
THP-1 macrophages
10 μM
24 hours
Isosilybin A significantly upregulated ABCA1 protein expression (1.25-fold), while other components like silybin B, silychristin, isosilychristin, and taxifolin also showed similar effects.
Molecules. 2015 Dec 31;21(1):E55
Huh7.5.1 human hepatoma cells
14.6 μM
72 hours
Inhibition of JFH-1 HCV RNA replication, IC50 of 14.6 μM
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-9
Huh7.5.1 human hepatoma cells
40 μM
72 hours
Inhibition of JFH-1 HCV infection, IC50 of 40 μM
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-9
THP-1 macrophages
1-30 μM
24 hours
Isosilybin A concentration-dependently induced cholesterol efflux (EC50=4.1 μM) and significantly upregulated ABCA1 protein expression (1.25-fold).
Molecules. 2015 Dec 31;21(1):E55
HEK-293 cells
30 μM
18 hours
To investigate the activation of PPAR γ by Isosilybin A, results showed that Isosilybin A significantly activated PPAR γ with a 2.08±0.48-fold activation.
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