Iproniazid | MAO Inhibitor | AmBeed-信号通路专用抑制剂

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Iproniazid/异丙烟肼 {[allProObj[0].p_purity_real_show]}

货号：A399744 同义名： N'-异丙基吡啶-4-酰肼 / Marsilid; Iprazid

Iproniazid是一种不可逆的非选择性单胺氧化酶（MAO）抑制剂。

Iproniazid/异丙烟肼化学结构
CAS号：54-92-2

Iproniazid/异丙烟肼 3D分子结构
CAS号：54-92-2

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Iproniazid/异丙烟肼纯度/质量文件产品仅供科研

货号：A399744 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]; • Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]; • Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]; • Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]; 更多 >

MAO 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			98%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	97%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	98%
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	98%
Tranylcypromine HCl		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	97%
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Iproniazid/异丙烟肼生物活性

描述

Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity^[1]. Iproniazid, which inhibits monoamine oxidase but not prostacyclin synthesis, failed to enhance platelet aggregation^[2]. Iproniazid was found to inhibit formalin-induced oedema of the foot, dextran-induced oedema and cotton-pellet-induced granulomatous tissue in the rat^[3]. 5-Hydroxytryptamine can interrupt pregnancy at all stages in mice but is particularly effective early and late in pregnancy. Iproniazid exerts its action essentially in the first half of pregnancy. 5-Hydroxytryptamine produces striking hemorrhage in the placenta^[4]. Chronic glucocorticoid treatment may have a slight inhibitory effect on brain MAO and also has the ability to partially reverse or antagonize the inhibition of MAO caused by iproniazid^[5]. Rats were bilaterally ovariectomized on Day 3 post coitum and treated daily with progesterone. Iproniazid, an inhibitor of monoamine oxidase, on Day 8 induced implantation in all rats^[6].

Iproniazid/异丙烟肼参考文献

[1]Inhibition of mono amine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors

[2]Rosenblum WI, El-Sabban F. Enhancement of platelet aggregation by tranylcypromine in mouse cerebral microvessels. Circ Res. 1978 Aug;43(2):238-41

[3]SETNIKAR I, SALVATERRA M, TEMELCOU O. Antiphlogistic activity of iproniazid. Br J Pharmacol Chemother. 1959 Dec;14(4):484-7

[4]POULSON E, BOTROS M, ROBSON JM. Effect of 5-hydroxytryptamine and iproniazid on pregnancy. Science. 1960 Apr 15;131(3407):1101-2

[5]Veals JW, Korduba CA, Symchowicz S. Effect of dexamethasone on monoamine oxidase inhibiton by iproniazid in rat brain. Eur J Pharmacol. 1977 Feb 7;41(3):291-9

[6]Pal AK, Pakrashi A. Induction of implantation in the rat by iproniazid. J Reprod Fertil. 1980 Mar;58(2):387-8

Iproniazid/异丙烟肼实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.58mL

1.12mL

0.56mL

27.90mL

5.58mL

2.79mL

55.80mL

11.16mL

5.58mL

Iproniazid/异丙烟肼技术信息

CAS号	54-92-2
分子式	C₉H₁₃N₃O
分子量	179.22
SMILES Code	O=C(NNC(C)C)C1=CC=NC=C1
MDL No.	MFCD00153819

别名	N'-异丙基吡啶-4-酰肼 ;Marsilid; Iprazid
运输	蓝冰
InChI Key	NYMGNSNKLVNMIA-UHFFFAOYSA-N
Pubchem ID	3748

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(585.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(557.98 mM)

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

Iproniazid/异丙烟肼 {[allProObj[0].p_purity_real_show]}

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