There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.
Hypaconitine/次乌头碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
chondrocytes
5, 10, 20 μg/ml
24 hours
To evaluate the cytotoxic effects of hypaconitine on chondrocytes. Results showed that hypaconitine at concentrations of 5, 10, 20 μg/ml significantly inhibited chondrocyte viability.
Front Pharmacol. 2020 Jul 24;11:1053
H9c2 cardiomyocytes
120 μmol/L
4 hours
Investigate the protective effect of HA+GA on OGD-induced injury, results showed HA+GA combination pretreatment significantly improved cell morphology and function, reduced apoptosis and necrosis
J Zhejiang Univ Sci B. 2017 Jul;18(7):586-596
Hypaconitine/次乌头碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
SD rats
Oral administration model
Oral
0.5 mg/kg, 1 mg/kg, 2 mg/kg
Single dose, lasting 8 hours
To study the pharmacokinetics of Hypaconitine in rats, showing fast absorption and slow elimination.
ACS Pharmacol Transl Sci. 2020 Dec 6;4(1):118-127
Rats
Chronic heart failure model
Oral
2.07 mg/kg
Once a day for 1 week
HA + GA showed protective effects on CHF in the rats, and the HA + GA may exert protective effects by reducing lipid levels, up-regulating the expression of FGF2 and VEGFA proteins, attenuating eNOS protein expression, and modulating metabolic pathways.
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