Hypaconitine

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Chemical Structure| 6900-87-4 同义名 : Deoxymesaconitine
CAS号 : 6900-87-4
货号 : A765513
分子式 : C33H45NO10
纯度 : 98%
分子量 : 615.71
MDL号 : MFCD00221744
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(81.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.12mL

1.62mL

0.81mL

16.24mL

3.25mL

1.62mL
参考文献

[1]Feng HT, Zhao WW, et al. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells. Chin J Nat Med. 2017 Jun;15(6):427-435.

[2]Bai Y, Du S, et al. Histone deacetylase-high mobility group box-1 pathway targeted by hypaconitine suppresses the apoptosis of endothelial cells. Exp Biol Med (Maywood). 2017 Mar;242(5):527-535.