货号:A2925916
同义名:
重组人Carbonic Anhydrase 11蛋白(C-6His, HEK293)
/ Recombinant Human Carbonic Anhydrase 11 (C-6His, HEK293); Carbonic Anhydrase-Related Protein 11
Recombinant Human Carbonic Anhydrase 11 (C-6His, HEK293) 是人源Carbonic Anhydrase-Related Protein 11(CA11)蛋白,在HEK293人源细胞中表达,带有C端6His标签。该蛋白属于α-碳酸酐酶家族,是一种分泌型蛋白,可催化二氧化碳的可逆水合反应,参与呼吸、酸碱平衡、骨吸收及脑脊液形成等生理过程,主要在大脑中高表达,可能在中枢神经系统中发挥重要作用。


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| 产品名称 | Carbonic Anhydrase ↓ ↑ | Carbonic Anhydrase I ↓ ↑ | Carbonic Anhydrase II ↓ ↑ | Carbonic Anhydrase IV ↓ ↑ | Carbonic Anhydrase IX ↓ ↑ | Carbonic Anhydrase XII ↓ ↑ | 其他靶点 | 纯度 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Topiramate | ✔ | Calcium Channel | 98% | ||||||||||||||||
| Dichlorphenamide | ✔ | 98% | |||||||||||||||||
| Mafenide Acetate | ✔ | 98% | |||||||||||||||||
| Benzenesulphonamide | ✔ | 98% | |||||||||||||||||
| Dorzolamide HCl |
+
Carbonic anhydrase I, Ki: 6000 nM |
++++
Carbonic anhydrase II, Ki: 1.9 nM |
+++
Carbonic anhydrase IV, Ki: 31 nM |
98% | |||||||||||||||
| Methazolamide |
++
hCAI, Ki: 50 nM |
+++
hCAII, Ki: 14 nM |
++
bCAIV, Ki: 36 nM |
98% | |||||||||||||||
| Tioxolone |
+
CAI, Ki: 91 nM |
98% | |||||||||||||||||
| U-104 |
++
CAIX, Ki: 45.1 nM |
++++
CAXII, Ki: 4.5 nM |
98% | ||||||||||||||||
| 1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 | |||||||||||||||||||
| 描述 | Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid. CA11 may play a general role in the central nervous system. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His |
| 蛋白表达区间 | His24-Arg328 |
| 蛋白编号 | O75493 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 35.1 KDa |
| SMILES Code | NONE |
| 别名 | 重组人Carbonic Anhydrase 11蛋白(C-6His, HEK293) ;Recombinant Human Carbonic Anhydrase 11 (C-6His, HEK293); Carbonic Anhydrase-Related Protein 11; CA-RP XI; CA-XI; CARP XI; Carbonic Anhydrase-Related Protein 2; CA-RP II; CARP-2; CA11; CARP2 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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