There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
GC7 treatment induced a decrease in eIF5A hypusination, shifting cell metabolism from oxidative phosphorylation to glycolysis, increasing glucose consumption and lactate efflux, while decreasing glucose uptake.
Cell Death Dis. 2021 Mar 17;12(4):283
CD4 deficient PBMCs
100μM/mL
7 days
To assess the ability of CD4 deficient PBMCs to convert into CD4+CD25+FOXP3+ Tregs under GC7+anti-DLL4 treatment. Results showed that 20.3±3.1% of CD8+ T cells converted into CD4+ T cells, with 45.6±8.8% further differentiating into CD4+CD25+FOXP3+ Tregs.
Immunotargets Ther. 2025 Mar 13;14:205-226
CD4+CD25− T cells
100μM/mL
7 days
To induce the conversion of CD4+CD25− T cells into CD4+CD25+FOXP3+ Tregs and evaluate their suppressive function. Results showed that 63.4±5.4% of CD4+CD25− T cells converted into CD4+CD25+ T cells with significant proliferative capacity.
Immunotargets Ther. 2025 Mar 13;14:205-226
cortical neurons
30 μM
12 hours
GC7 significantly reduced neuronal death induced by oxygen-glucose deprivation (OGD) and protected mitochondrial membrane potential and reduced ROS generation
Once daily for the first 3 days, then every 2 days for 14 days
Inhibited tumor growth and M2-like TAM infiltration
Cell Death Dis. 2023 Aug 31;14(8):579
Nude mice
A375 cell xenograft model
Intraperitoneal injection
40 mg/kg
Every 3 days for 18 days
Evaluate the inhibitory effect of GC-7 on tumor growth, results showed GC-7 had a weaker inhibitory effect on tumor growth
Adv Sci (Weinh). 2024 Sep;11(33):e2402450
Nude mice
HCT116 xenograft model
Intraperitoneal injection
4 mg/kg
Daily for 15 days
GC7 significantly decreased tumor growth and EIF5A hypusination
Cell Death Dis. 2020 Dec 10;11(12):1045
Mouse
C57BL/6 male mice
Intraperitoneal injection
3 mg/kg
Once daily for 3 days
GC7 treatment reduced eIF5A hypusination in the kidney, decreased GLUT1 protein expression, and increased urinary glucose and lactate excretion without affecting renal function.
Cell Death Dis. 2021 Mar 17;12(4):283
C57BL/6J mice
Transient focal cerebral ischemia (tFCI) model
Intraperitoneal injection
3 mg/kg
Pretreatment: single or three injections at 48, 24, 2 h before; Post-treatment: sequential injections at 2 h, 2d, 4d, 7d, 10d, 14d, and 17d after
GC7 significantly reduced brain infarct volume and improved motor and cognitive functional recovery
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