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其他 PEPT 核苷抗代谢物
/ Floxuridine/氟尿苷

Floxuridine/氟尿苷 {[allProObj[0].p_purity_real_show]}

货号：A230277 同义名： 氟尿苷 / 5-Fluorouracil 2'-deoxyriboside; 5-FDU

Floxuridine 是一种抗肿瘤化合物，属于抗代谢药物，抑制 PEPT1 的 GI50 为 5.1 μM。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Floxuridine/氟尿苷 化学结构 CAS号：50-91-9
Floxuridine/氟尿苷 化学结构
CAS号：50-91-9
Floxuridine/氟尿苷 3D分子结构
CAS号：50-91-9
Floxuridine/氟尿苷 化学结构 CAS号：50-91-9
Floxuridine/氟尿苷 3D分子结构 CAS号：50-91-9
规格 价格 会员价 库存 数量
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Floxuridine/氟尿苷 纯度/质量文件 产品仅供科研

货号：A230277 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLM636-1298, IC50: 0.97 μM

BLMfull-length, IC50: 2.98 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Floxuridine/氟尿苷 生物活性

描述 Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine (0-25 μM; 4-24 hours) is affectd by inhibitors of PARP and its sensitivity of ovarian cancer cells is enhanced. Co-exposed to FdUrd and the PARP inhibitor markedly increases killing cell numbers when its compare to treatment alone in ovarian cancer cells. Floxuridine (300 μM; 4-24 hours) increases p-Chk1 and p-Chk2 in ovarian cancer cell lines. It may induce DNA damage and activate the ATM and ATR checkpoint signaling pathways. Floxuridine (0-2.5 μM; 24 hours) causes a G1/S-phase arrest and following removal of the FdUrd, the G1/S-phase-arrested cells moved synchronously through S phase and into G2/M[3]. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction[4]. Floxuridine is against Mueller Hinton Broth and Tryptic Soy Broth with MIC values of 0.25 μM and 0.81 μM, respectively. It also reported to be a very potent inhibitor of staphylococcal growth (MIC, 0.025–0.00313 μM)[5].

Floxuridine/氟尿苷 细胞实验

Cell Line
Concentration Treated Time Description References
WiDr cells 0–115.2 μM 48 hours To test the effect of terbinafine on WiDr cell proliferation, results showed that terbinafine enhanced the sensitivity to 5-FU. Cell Commun Signal. 2024 May 18;22(1):278.
RKO cells 0–115.2 μM 48 hours To test the effect of terbinafine on RKO cell proliferation, results showed that terbinafine enhanced the sensitivity to 5-FU. Cell Commun Signal. 2024 May 18;22(1):278.
Streptococcus suis SS3 0.5 µg/mL 8-12 h To evaluate the antibacterial activity of floxuridine against S. suis, results showed potent antibacterial effects in vitro Int J Mol Sci. 2023 Sep 18;24(18):14211.
Streptococcus suis ATCC 43765 0.25 µg/mL 8-12 h To evaluate the antibacterial activity of floxuridine against S. suis, results showed potent antibacterial effects in vitro Int J Mol Sci. 2023 Sep 18;24(18):14211.
mouse mammary carcinoma FM3A cells F28-7-A 1 μM 21 h induces apoptosis Int J Mol Sci. 2020 Aug 16;21(16):5876.
mouse mammary carcinoma FM3A cells F28-7 1 μM 21 h induces necrosis Int J Mol Sci. 2020 Aug 16;21(16):5876.

Floxuridine/氟尿苷 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/C mice Peritonitis model Intraperitoneal injection 25 and 50 mg/kg Single dose, monitored for 5 days To evaluate the therapeutic effect of floxuridine against S. suis infection, results showed significant improvement in survival rate and reduction in bacterial load Int J Mol Sci. 2023 Sep 18;24(18):14211.

Floxuridine/氟尿苷 参考文献

[1]Tsume Y, Hilfinger JM, Amidon GL. Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.

[2]Mini E, Moroson BA, Bertino JR. Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin. Cancer Treat Rep. 1987 Apr;71(4):381-9.

[3]Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 2011 Jul 15;71(14):4944-54

[4]Power DG, Kemeny NE. The role of floxuridine in metastatic liver disease. Mol Cancer Ther. 2009 May;8(5):1015-25

[5]Yeo WS, Arya R, Kim KK, Jeong H, Cho KH, Bae T. The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus. Sci Rep. 2018 Feb 6;8(1):2521

Floxuridine/氟尿苷 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.31mL

4.06mL

2.03mL

40.62mL

8.12mL

4.06mL

Floxuridine/氟尿苷 技术信息

CAS号50-91-9
分子式C9H11FN2O5
分子量 246.19
SMILES Code OC[C@@H]1[C@H](C[C@H](N2C(NC(C(F)=C2)=O)=O)O1)O
MDL No. MFCD00006530
别名 氟尿苷 ;5-Fluorouracil 2'-deoxyriboside; 5-FDU; FUdR. WR138720.; FDUR; fluoruridine deoxyribose. FUDF. 5FUDR; fluorouridine deoxyribose; fluorodeoxyuridine; floxuridin; NSC 26740; 5-FUDR; 5-Fluorodeoxyuridine; FdUrd; NSC 27640
运输蓝冰
InChI Key ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Pubchem ID 5790
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 120 mg/mL(487.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(203.09 mM)

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Floxuridine | Apoptosis Inducer | Nucleoside Antimetabolite/Analog | CMV | Apoptosis | HSV | DNA/RNA Synthesis | Antibacterial | Antiparasitic | AmBeed-信号通路专用抑制剂 | Floxuridine/氟尿苷 纯度/质量文件 | Floxuridine/氟尿苷 亚型比较 | Floxuridine/氟尿苷 生物活性 | Floxuridine/氟尿苷 参考文献 | Floxuridine/氟尿苷 实验方案 | Floxuridine/氟尿苷 技术信息

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