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/ Eriocitrin/圣草次苷

Eriocitrin/圣草次苷 {[allProObj[0].p_purity_real_show]}

货号：A205759 同义名： 圣草次甙 / Eriodictioside; eriodictyol 7-rutinoside

Eriocitrin是一种从 Citrus sinensis (L.) Osbeck 果实中提取并纯化的天然产物，具有抗氧化活性。

Eriocitrin/圣草次苷 化学结构 CAS号：13463-28-0
Eriocitrin/圣草次苷 化学结构
CAS号：13463-28-0
Eriocitrin/圣草次苷 3D分子结构
CAS号：13463-28-0
Eriocitrin/圣草次苷 化学结构 CAS号：13463-28-0
Eriocitrin/圣草次苷 3D分子结构 CAS号：13463-28-0
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Eriocitrin/圣草次苷 纯度/质量文件 产品仅供科研

货号：A205759 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >

Eriocitrin/圣草次苷 生物活性

描述 Eriocitrin is a flavonoid isolated from lemon, which is a strong antioxidant agent. Eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating mitochondria-involved intrinsic signaling pathway[3]. Eriocitrin attenuated oxidative injury and inflammatory response in rats with CI/R (cerebral ischemia reperfusion) via the Nrf2/HO-1/NQO1/NF-κB signaling pathway[4]. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading[5]. The 25 mg dose of eriocitrin had positive effects on oxidative stress, systemic inflammation and metabolism of lipids and glucose in general[6].

Eriocitrin/圣草次苷 细胞实验

Cell Line
Concentration Treated Time Description References
Human umbilical vein endothelial cells (HUVECs) 25-100 µM 24 hours Evaluate the effect of Eriocitrin on apoptosis in HUVECs, showing evident induction of cell apoptosis. Nutrients. 2024 Apr 8;16(7):1091
Human umbilical vein endothelial cells (HUVECs) 25-100 µM 24 hours Assess the effect of Eriocitrin on HUVECs migration, showing significant reduction in migrating cell numbers. Nutrients. 2024 Apr 8;16(7):1091
Human umbilical vein endothelial cells (HUVECs) 25-100 µM 24 hours Evaluate the effect of Eriocitrin on tube formation in HUVECs, showing significant inhibition of tubular structure formation. Nutrients. 2024 Apr 8;16(7):1091
Human umbilical vein endothelial cells (HUVECs) 25-100 µM 48 hours Assess the cytotoxicity of Eriocitrin on HUVECs, showing no significant LDH release at tested concentrations. Nutrients. 2024 Apr 8;16(7):1091
Human umbilical vein endothelial cells (HUVECs) 25-100 µM 24 hours Evaluate the effect of Eriocitrin on HUVECs proliferation, showing no significant effect on cell viability at tested concentrations. Nutrients. 2024 Apr 8;16(7):1091
H1299 cells 50 μM 24 hours To evaluate the effect of Eriocitrin on the EMT process of H1299 cells, the results showed that Eriocitrin upregulated E-cadherin expression and downregulated N-cadherin and vimentin expression. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
A549 cells 50 μM 24 hours To evaluate the effect of Eriocitrin on the EMT process of A549 cells, the results showed that Eriocitrin upregulated E-cadherin expression and downregulated N-cadherin and vimentin expression. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
H1299 cells 0, 25, 50, 75, 100 μM 24 or 48 hours To evaluate the effect of Eriocitrin on the migration ability of H1299 cells, the results showed that Eriocitrin significantly inhibited cell migration. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
A549 cells 0, 25, 50, 75, 100 μM 24 or 48 hours To evaluate the effect of Eriocitrin on the migration ability of A549 cells, the results showed that Eriocitrin significantly inhibited cell migration. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
H1299 cells 0, 5, 10, 20, 40, 80, 160 μM 24 or 48 hours To evaluate the effect of Eriocitrin on the viability of H1299 cells, the results showed that Eriocitrin significantly inhibited cell viability in a concentration-dependent manner. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
A549 cells 0, 5, 10, 20, 40, 80, 160 μM 24 or 48 hours To evaluate the effect of Eriocitrin on the viability of A549 cells, the results showed that Eriocitrin significantly inhibited cell viability in a concentration-dependent manner. Aging (Albany NY). 2023 Oct 2;15(19):10089-10104
Erythrocytes 10–100 μM 24 hours To evaluate the hemolytic and eryptotic effects of ERN on erythrocytes, results showed significant hemolysis and eryptosis Pharmaceuticals (Basel). 2023 Dec 2;16(12):1681
Caco-2 cells 10 µM 24 hours To evaluate the anti-inflammatory effects of FM and DFM on IL-1β-induced inflammatory response. Results showed that FM and DFM significantly reduced the release of IL-6, IL-8, and NO, comparable to or stronger than the anti-inflammatory drug dexamethasone. Antioxidants (Basel). 2021 Jan 20;10(2):140

Eriocitrin/圣草次苷 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Chick embryos Chick embryo chorioallantoic membrane (CAM) model Topical administration 5-50 nmol/egg Single dose, observed for 2 days Evaluate the effect of Eriocitrin on angiogenesis in chick embryos, showing significant suppression of new blood vessel formation. Nutrients. 2024 Apr 8;16(7):1091

Eriocitrin/圣草次苷 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02627547 Healthy Not Applicable Completed - United Kingdom ... 展开 >> University of Glasgow School of Medicine Glasgow, United Kingdom 收起 <<
NCT03482401 Breast Cancer Not Applicable Active, not recruiting June 1, 2019 Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT03215043 Pre Diabetes Not Applicable Recruiting June 28, 2019 Brazil ... 展开 >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D.    +55 16 3301-6927    tcesar@fcfar.unesp.br 收起 <<

Eriocitrin/圣草次苷 参考文献

[1]Hiramitsu M, Shimada Y, et al. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708.

[2]Minato K, Miyake Y, et al. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci. 2003 Feb 21;72(14):1609-16.

[3]Wang Z, Zhang H, Zhou J, Zhang X, Chen L, Chen K, Huang Z. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150

[4]He J, Zhou D, Yan B. Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins. Ann Transl Med. 2020 Jun;8(12):757

[5]Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708

[6]Ferreira PS, Manthey JA, Nery MS, Spolidorio LC, Cesar TB. Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice. J Nutr Sci. 2020 Dec 14;9:e59

Eriocitrin/圣草次苷 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL

Eriocitrin/圣草次苷 技术信息

CAS号13463-28-0
分子式C27H32O15
分子量 596.53
SMILES Code O=C1C[C@@H](C2=CC=C(O)C(O)=C2)OC3=C1C(O)=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=C3
MDL No. MFCD00017472
别名 圣草次甙 ;Eriodictioside; eriodictyol 7-rutinoside; Eriocitrin, Eriodictioside, Eriodictyol 7-O-rutinoside; Eriodictyol 7-O-rutinoside; Eriodictyol glycoside
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 105 mg/mL(176.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Eriocitrin | 13463-28-0 | Apoptosis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Eriocitrin/圣草次苷 纯度/质量文件 | Eriocitrin/圣草次苷 生物活性 | Eriocitrin/圣草次苷 临床数据 | Eriocitrin/圣草次苷 参考文献 | Eriocitrin/圣草次苷 实验方案 | Eriocitrin/圣草次苷 技术信息

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