There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Eldecalcitol, an analog of vitamin D, is a drug used for the treatment of osteoporosis.
Eldecalcitol/艾地骨化醇 细胞实验
Cell Line
Concentration
Treated Time
Description
References
CX3CR1-positive cells from CX3CR1-EGFP knockin mice
10^-9 to 10^-8 M
2 days
Suppressed S1PR2 expression
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7009-13
CSF1R-positive cells from CSF1R-EGFP transgenic mice
10^-9 to 10^-8 M
2 days
Suppressed S1PR2 expression
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7009-13
RAW264.7 cells
10^-9 to 10^-8 M
2 days
Suppressed S1PR2 expression and enhanced chemotaxis to S1P
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7009-13
RAW264.7 cells
1 × 10–9 M
48 hours
To evaluate the effect of ED-71 on RAW264.7 cell polarization, results showed that ED-71 alone promoted M2 macrophage polarization.
Stem Cell Res Ther. 2022 Mar 21;13(1):113
CD4+ T cells
1 nM
48 hours
To evaluate the effect of ED-71 on Treg cell differentiation under high glucose conditions, results showed ED-71 improved HG-inhibited Treg cell differentiation.
Cell Mol Life Sci. 2024 Oct 5;81(1):423
Human gingival fibroblasts (HGFs)
0, 0.5, 5, 50 nM
24 hours
To evaluate the inhibitory effect of ED-71 on LPS-induced cell death. Results showed that ED-71 pretreatment significantly reduced LPS-induced cell death.
Drug Des Devel Ther. 2020 Nov 13;14:4901-4913
C2C12 cells
0.1, 1, and 10 nM
24 hours
To investigate the effect of eldecalcitol on TNF-α-induced muscle atrophy. Eldecalcitol significantly inhibited the expression of MuRF-1 and Atrogin-1, increased the diameter of myotubes, and inhibited the NF-κB signaling pathway.
Skelet Muscle. 2023 Dec 19;13(1):22
Eldecalcitol/艾地骨化醇 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J male mice
Tail suspension model
Intraperitoneal injection
3.5 or 5 ng
Twice a week for 3 weeks
To investigate the effect of eldecalcitol on tail suspension-induced muscle atrophy and osteoporosis. Eldecalcitol significantly improved grip strength, restored muscle weight, improved bone microarchitecture, and restored the impaired oxidative defense system.
Skelet Muscle. 2023 Dec 19;13(1):22
C57BLKS/J Iar-+ Leprdb/+ Leprdb mice
Diabetic osteoporosis model
Oral
0.25 μg/kg
3 times per week for 4 weeks
To evaluate the effect of ED-71 on bone formation in diabetic osteoporosis mice, results showed that ED-71 significantly enhanced bone formation and promoted M2 macrophage polarization.
Stem Cell Res Ther. 2022 Mar 21;13(1):113
Mice
Glucocorticoid-induced osteoporosis model
Oral gavage
50 ng/kg/d
5 times per week for 8 weeks
Prevented GC-induced upregulation of atrogin1 and MuRF1 expression, preserved bone structure and function
JCI Insight. 2024 Nov 8;9(21):e182664
Mice
Type 2 diabetes model
Oral
0.25 µg/kg
3 times per week for 4 weeks
To evaluate the therapeutic effects of ED-71 on diabetic osteoporosis and glucolipid metabolic disorder, results showed ED-71 attenuated bone loss and marrow adiposity while improving glucolipid metabolism.
Cell Mol Life Sci. 2024 Oct 5;81(1):423
Mice
Ovariectomy-induced osteoporosis model
Oral
50 ng/kg body weight
Once daily for 4 weeks
Prevented osteoporosis and suppressed S1PR2 expression in circulating monocytes
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7009-13
Rats
Ovariectomized rat model
Oral
30 or 90 ng/kg body weight
Five times per week for 12 weeks
To examine the effects of Eldecalcitol on bone in ovariectomized rats, showing that ELD increased bone volume and trabecular thickness, reduced osteoclast numbers, and preferentially induced minimodeling-based bone formation in the epiphyses.
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