There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of drofenine is calculated to be 3 μM.
Drofenine HCl/盐酸六氢芬宁 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Primary microglia
10 μmol/L
To evaluate the inhibitory effect of Drofenine on NLRP3 inflammasome activation in microglia. Results showed that Drofenine inhibited Aβ-induced NLRP3 inflammasome activation.
Acta Pharm Sin B. 2025 Jan;15(1):371-391
HaCaT cells
50-1000 μmol/L
Evaluating the activation of TRPV3 by Drofenine in HaCaT cells, with an EC50 of 605 μmol/L, and more effective than 2-APB and carvacrol.
Pharmacol Res Perspect. 2014 Oct;2(5):e00062
CHO-Kv2.1 cells
10 μmol/L
12 hours
To evaluate the inhibitory effect of Drofenine on Kv2.1 channel and its impact on potassium efflux. Results showed that Drofenine inhibited Aβ-induced potassium efflux.
Acta Pharm Sin B. 2025 Jan;15(1):371-391
CHO-Kv2.1 cell
5, 10, 20 μM
30 minutes
Dfe inhibited membrane potential in CHO-Kv2.1 cell with an IC50 of 9.53 μM.
iScience. 2020 Sep 28;23(10):101617
Drofenine HCl/盐酸六氢芬宁 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
5×FAD-AD mice
5×FAD-AD mouse model
Intraperitoneal injection
10 mg/kg/day
Once daily for 8 weeks
To evaluate the ameliorative effect of Drofenine on cognitive impairment in 5×FAD-AD mice. Results showed that Drofenine improved cognitive function in mice.
Acta Pharm Sin B. 2025 Jan;15(1):371-391
Mice
Diabetic peripheral neuropathy (DPN) model
Intraperitoneal injection
10, 20 mg/kg
Once daily for 4 weeks
Dfe ameliorated DPN-like pathology in diabetic mice by inhibiting Kv2.1 channel, including promoting neurite outgrowth, improving nerve conduction deficiency and hypoalgesia.
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