Drofenine HCl

产品说明书

Print
Chemical Structure| 548-66-3 同义名 : Hexahydroadiphenine hydrochloride; Drofenine Hydrochloride; Hexahydroadiphenine hydrochloride, IT-19, NSC 42559, Profenene hydrochloride, Trasentin H, Trasentine A, Trasentine-A; Cycloadiphenine hydrochloride, Cyclohexylphenylacetyldiethylaminoethanol hydrochloride, Cyclospasmol (tempelhof), Cyclovegantine, Drofenine HCl, Drofenine hydrochloride
CAS号 : 548-66-3
货号 : A310094
分子式 : C20H32ClNO2
纯度 : 98%
分子量 : 353.93
MDL号 : MFCD00034983
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(226.04 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(84.76 mM)
生物活性
描述 Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of drofenine is calculated to be 3 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.13mL

2.83mL

1.41mL

28.25mL

5.65mL

2.83mL
参考文献

[1]Bodur E, Cokuğraş AN, et al. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-9.