Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi. Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml[3]. Dictamnine exhibited no obvious antibacterial activity against UPEC, but significantly impeded the ability of UPEC (Uropathogenic Escherichia coli) to adhere to and invade uroepithelial cells[4]. Among all cancer cell lines tested, Dic inhibited the proliferation of c-Met-dependent EBC-1 cells with the greatest potency (IC50 = 2.811 μM). Notably, Dic was shown to synergistically improve the chemo-sensitivity of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-resistant lung cancer cells to gefitinib and osimertinib[5]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA (dihydroartemisinin) enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway[6].
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