Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
抗生素和抗病毒 肿瘤
/
DNA损伤
细胞周期 结构 肿瘤表观遗传和基因调控
/
DNA
核苷类
/ Cordycepin/虫草素

Cordycepin/虫草素 {[allProObj[0].p_purity_real_show]}

货号：A210754 同义名： 虫草素（3'-脱氧腺苷） / 3'-Deoxyadenosine; NSC 63984

Cordycepin是一种腺苷衍生物，能够抑制肿瘤细胞的生长，并具有抗炎和抗氧化作用。它通过转化为 3'-去氧腺苷三磷酸（3'-dATP）抑制 DNA 合成。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Cordycepin/虫草素 化学结构 CAS号：73-03-0
Cordycepin/虫草素 化学结构
CAS号：73-03-0
Cordycepin/虫草素 3D分子结构
CAS号：73-03-0
Cordycepin/虫草素 化学结构 CAS号：73-03-0
Cordycepin/虫草素 3D分子结构 CAS号：73-03-0
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Cordycepin/虫草素 纯度/质量文件 产品仅供科研

货号：A210754 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLM636-1298, IC50: 0.97 μM

BLMfull-length, IC50: 2.98 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 95%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cordycepin/虫草素 生物活性

描述 Cordycepin (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological activities, such as anti-cancer, anti-inflammatory and anti-infection activities. Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs(RA synovial fibroblasts) [3]. Co-use of cordycepin and deoxycoformycin, an inhibitor of adenosine deaminase (ADD), more efficiently kills M. bovis and M. tuberculosis. The add-deleted mycobacterium is more sensitive to cordycepin[4]. Cordycepin can induce apoptosis, resist cell cycle and cause DNA damage in cancer cells, and thus kill or control cancer cell growth. Also cordycepin can induce autophagy and modulate immune system. Furthermore, cordycepin also inhibits tumor metastasis[5]. Cordycepin inhibited the nuclear translocation of P65 by preventing p‑IκBα(NF‑κB inhibitor α) activation; this resulted in the downregulation of CXCR4 (C‑X‑C chemokine receptor type 4) expression, and subsequently, in the impaired migration and invasion abilities of liver cancer cells and attenuated reactivity to SDF1(stromal cell‑derived factor 1) [6].

Cordycepin/虫草素 细胞实验

Cell Line
Concentration Treated Time Description References
3T3-L1 preadipocytes 10 μM 24 h Cordycepin significantly inhibited the differentiation of 3T3-L1 preadipocytes into adipocytes, reduced lipid accumulation, and increased the expression of brown adipocyte markers (e.g., UCP1, CIDEA, PGC1α, and FNDC5). These effects were substantially abolished in the presence of the AMPK inhibitor Compound C. Acta Pharm Sin B. 2019 Jan;9(1):135-143.
Primary microglial cells 500 ng/mL 24 h To evaluate the effect of cordycepin on primary microglial cell polarization and metabolic reprogramming. Results showed that cordycepin promoted primary microglial cell polarization towards M2-like phenotype and restored glycolysis and OXPHOS levels. Adv Sci (Weinh). 2024 Aug;11(31):e2304687.
BV2 cells 500 ng/mL 24 h To evaluate the effect of cordycepin on LPS +Aβ-induced BV2 cell polarization and metabolic reprogramming. Results showed that cordycepin promoted BV2 cell polarization towards M2-like phenotype and restored glycolysis and OXPHOS levels. Adv Sci (Weinh). 2024 Aug;11(31):e2304687.
HaCaT cells 200 μM 3 days Decreased levels of the senescence marker p16 and p21 proteins, reduced SASP and SA-β-gal activity Nat Commun. 2019 Jun 10;10(1):2538.
skin fibroblasts 200 μM 3 days Reduced levels of the DNA damage response marker γ-H2AX, decreased levels of the senescence marker p16 and p21 proteins, reduced SASP and SA-β-gal activity Nat Commun. 2019 Jun 10;10(1):2538.
Primary hepatocytes 50 μM and 100 μM 12 h To validate the effects of cordycepin on lipid metabolism and inflammation in primary hepatocytes. Cordycepin reduced lipid accumulation and downregulated the expression of fatty acid synthesis genes (Fasn, Scd1, Accα, Srebp) and inflammatory genes (Il1b, Il6, Tnfα, Ccl5, Cxcl10). Hepatology. 2021 Aug;74(2):686-703.
L02 cells 50 μM and 100 μM 12 h To evaluate the effects of cordycepin on lipid accumulation and inflammation in hepatocytes under metabolic stress. Cordycepin significantly reduced lipid droplet accumulation, decreased intracellular triglyceride (TG) and total cholesterol (TC) levels, and downregulated the expression of fatty acid synthesis genes (Fasn, Scd1, Accα, Pparγ) and inflammatory genes (Il6, Tnfα, Ccl5, Cxcl10). Hepatology. 2021 Aug;74(2):686-703.
Bone marrow-derived neutrophils 10 μg/mL 2 h To evaluate the effect of cordycepin on neutrophil chemotaxis, results showed cordycepin did not directly affect neutrophil chemotaxis J Neuroinflammation. 2021 Jun 15;18(1):137.
human dermal fibroblasts 50 μM and 100 μM 24 h To evaluate the inhibitory effect of cordycepin on UVB-induced MMP-1 and MMP-3 expressions. Results showed that cordycepin inhibited UVB-induced MMP-1 and MMP-3 expressions in a dose-dependent manner. Exp Mol Med. 2009 Aug 31;41(8):548-54.
ECA109 cells 73.82 μM 48 h Cordycepin and cisplatin synergistically inhibited the proliferation of esophageal cancer cells Cell Death Dis. 2020 Oct 16;11(10):866.
K70 cells 69.27 μM 48 h Cordycepin and cisplatin synergistically inhibited the proliferation of esophageal cancer cells Cell Death Dis. 2020 Oct 16;11(10):866.
K180 cells 66.84 μM 48 h Cordycepin and cisplatin synergistically inhibited the proliferation of esophageal cancer cells Cell Death Dis. 2020 Oct 16;11(10):866.
HK cells 86.12 μM 48 h Cordycepin and cisplatin synergistically inhibited the proliferation of esophageal cancer cells Cell Death Dis. 2020 Oct 16;11(10):866.

Cordycepin/虫草素 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 male mice High-fat diet-induced obesity model Oral gavage 40 mg/kg Once daily for 4 weeks Cordycepin significantly inhibited high-fat diet-induced weight gain, reduced white adipose tissue (WAT) mass, and improved metabolic profiles and glucose tolerance. Additionally, cordycepin promoted WAT browning, increased energy expenditure, and enhanced cold tolerance. These effects were associated with AMPK activation. Acta Pharm Sin B. 2019 Jan;9(1):135-143.
APP/PS1 mice Alzheimer's disease model Intragastric administration 10 mg/kg Once daily for 4 weeks To evaluate the effect of cordycepin on cognitive function and neuronal damage in APP/PS1 mice. Results showed that cordycepin improved learning and memory abilities and attenuated neuronal damage in APP/PS1 mice. Adv Sci (Weinh). 2024 Aug;11(31):e2304687.
Mice High-fat diet (HFD)-induced nonalcoholic steatohepatitis (NASH) model 100 mg/kg and 200 mg/kg Daily administration for 8 weeks To evaluate the effects of cordycepin on HFD-induced hepatic steatosis and inflammation. Cordycepin significantly reduced liver weight (LW) and liver weight/body weight ratio (LW/BW), decreased hepatic and serum lipid (TG and TC) levels, and improved hepatic steatosis and inflammation. Hepatology. 2021 Aug;74(2):686-703.
Male C57BL/6 mice Controlled cortical impact (CCI)-induced traumatic brain injury (TBI) model Intraperitoneal injection 10 mg/kg Twice daily for one week To evaluate the long-term neuroprotective effects of cordycepin in TBI mice, results showed cordycepin improved neurological deficits, reduced neuronal tissue loss, and preserved white matter integrity J Neuroinflammation. 2021 Jun 15;18(1):137.
Nude mice Esophageal cancer xenograft model Intraperitoneal injection 25 mg/kg Every 4 days Cordycepin and cisplatin synergistically inhibited the growth of esophageal cancer xenograft tumors Cell Death Dis. 2020 Oct 16;11(10):866.

Cordycepin/虫草素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00667329 Lymphoma Phase 1 Active, not recruiting July 2019 United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00483067 Leukemia Phase 2 Completed - United States, Texas ... 展开 >> U.T.M.D. Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00412594 Leukemia Phase 2 Recruiting June 2019 United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 收起 <<

Cordycepin/虫草素 参考文献

[1]Kodama EN, McCaffrey RP, et al. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem Pharmacol. 2000 Feb 1;59(3):273-81.

[2]Sugar AM, McCaffrey RP. Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 1998 Jun;42(6):1424-7.

[3]Noh EM, Kim JS, Hur H, Park BH, Song EK, Han MK, Kwon KB, Yoo WH, Shim IK, Lee SJ, Youn HJ, Lee YR. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8

[4]Huang F, Li W, Xu H, Qin H, He ZG. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. PLoS One. 2019 Jun 14;14(6):e0218449

[5]Khan MA, Tania M. Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects. Curr Med Chem. 2020;27(6):983-996

[6]Guo Z, Chen W, Dai G, Huang Y. Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med. 2020 Jan;45(1):141-150

Cordycepin/虫草素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.98mL

0.80mL

0.40mL

19.90mL

3.98mL

1.99mL

39.80mL

7.96mL

3.98mL

Cordycepin/虫草素 技术信息

CAS号73-03-0
分子式C10H13N5O3
分子量 251.24
SMILES Code OC[C@@H]1C[C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O
MDL No. MFCD00037998
别名 虫草素（3'-脱氧腺苷） ;3'-Deoxyadenosine; NSC 63984; 9(3DeoxyDribofuranosyl)adenine; 3Deoxyadenosine; NSC 401022
运输蓝冰
InChI Key OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Pubchem ID 6303
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 35 mg/mL(139.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(7.96 mM)，配合低频超声，并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一
方案 二

Tags: Cordycepin | 3'-Deoxyadenosine;NSC 63984;9(3DeoxyDribofuranosyl)adenine;3Deoxyadenosine;NSC 401022 | 虫草素（3'-脱氧腺苷） | Plant Standard | Nucleoside | DNA/RNA Synthesis | AmBeed-信号通路专用抑制剂 | Cordycepin/虫草素 纯度/质量文件 | Cordycepin/虫草素 亚型比较 | Cordycepin/虫草素 生物活性 | Cordycepin/虫草素 临床数据 | Cordycepin/虫草素 参考文献 | Cordycepin/虫草素 实验方案 | Cordycepin/虫草素 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z